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[미국특허] Telomerase 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07H-021/04
  • A61K-038/00
  • C07K-016/00
  • C07K-017/00
출원번호 US-0854050 (1997-05-09)
발명자 / 주소
  • Cech Thomas R.
  • Lingner Joachim,CHX
  • Nakamura Toru
  • Chapman Karen B.
  • Morin Gregg B.
  • Harley Calvin B.
  • Andrews William H.
출원인 / 주소
  • University Technology Corporation
대리인 / 주소
    Earp
인용정보 피인용 횟수 : 67  인용 특허 : 14

초록 ▼

The present invention is directed to telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subunits of Euplotes a

대표청구항 ▼

[ We claim:] [1.]1. A synthetic or recombinant human telomerase reverse transcriptase (hTRT) protein, or a variant thereof, or a fragment thereof, wherein said variant is encoded by a polynucleotide that hybridizes under stringent conditions to a polynucleotide having a sequence complementary to SEO

이 특허에 인용된 특허 (14) 인용/피인용 타임라인 분석

  1. Tom Henry K. (La Honda CA) Rowley Gerald L. (Cupertino CA), Concentrating zone method in heterogeneous immunoassays.
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  2. Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
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  3. Kronick Melvyn N. (Palo Alto CA) Little William A. (Palo Alto CA), Fluorescent immunoassay employing total reflection for activation.
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  4. Collins Kathleen, Human telomerase.
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  5. Cao Zhaodan, Human telomerase RNA interacting protein gene.
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  6. Maggio Edward T. (Redwood City CA), Kit for carrying out chemically induced fluorescence immunoassay.
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  7. Litman David J. (Palo Alto CA) Harel Zvi (Stanford CA) Ullman Edwin F. (Atherton CA), Macromolecular environment control in specific receptor assays.
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  8. Villeponteau Bryant (San Carlos CA) Feng Junli (San Carlos CA) Funk Walter (Union City CA) Andrews William H. (Richmond CA), Mammalian telomerase.
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  9. Mullis Kary B. (Kensington CA), Process for amplifying nucleic acid sequences.
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  10. Mullis Kary B. (La Jolla CA) Erlich Henry A. (Oakland CA) Gelfand David H. (Oakland CA) Horn Glenn (Emeryville CA) Saiki Randall K. (Richmond CA), Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme.
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  11. Mullis Kary B. (Kensington CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or-cloning nucleic acid sequences.
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  12. Cabilly Shmuel (Monrovia CA) Heyneker Herbert L. (Burlingame CA) Holmes William E. (Pacifica CA) Riggs Arthur D. (La Verne CA) Wetzel Ronald B. (San Francisco CA), Recombinant immunoglobin preparations.
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  13. Cech Thomas R. ; Lingner Joachim,CHX, Telomerase.
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  14. West Michael D. (Belmont CA) Shay Jerry (Dallas TX) Wright Woodring (Arlington TX), Therapy and diagnosis of conditions related to telomere length and/or telomerase activity.
    상세보기

이 특허를 인용한 특허 (67) 인용/피인용 타임라인 분석

  1. Denning,Chris; Clark,A. John; Schiff,J. Michael, Animal tissue with carbohydrate antigens compatible for human transplantation.
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  2. Cech,Thomas R.; Lingner,Joachim; Nakamura,Toru; Chapman,Karen B.; Morin,Gregg B.; Harley,Calvin B.; Andrews,William H., Antibody to telomerase reverse transcriptase.
    상세보기
  3. Cech, Thomas R.; Lingner, Joachim; Nakamura, Toru; Chapman, Karen B.; Morin, Gregg B.; Harley, Calvin B.; Andrews, William H., Antibody to telomerase reverse transcriptive.
    상세보기
  4. Deen, Dennis F.; Frey, II, William H.; Gryaznov, Sergei, CNS-tumor treatment method and composition.
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  5. Binder, Joseph John; Cockle, Paul Jason; Falconer, Derek John; Guru, Siradanahalli; Jooss, Karin Ute; Martinic, Marianne Marcela Andrea; Wills, Kenneth Nelson; Cho, Helen Kim, Cancer vaccines.
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  6. Xu,Chunhui, Cardiomyocyte precursors from human embryonic stem cells.
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  7. Cech, Thomas R.; Lingner, Joachim; Nakamura, Toru; Chapman, Karen B.; Morin, Gregg B.; Harley, Calvin B.; Andrews, William H., Cells immortalized with telomerase reverse transcriptase for use in drug screening.
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  8. Gaeta, Federico C. A., Cellular telomerase vaccine and its use for treating cancer.
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  20. Cech, Thomas R.; Lingner, Joachim; Nakamura, Toru; Chapman, Karen B.; Morin, Gregg B.; Harley, Calvin B.; Andrews, William H., Human telomerase reverse transcriptase polypeptides.
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  23. Cech, Thomas R.; Lingner, Joachim; Nakamura, Toru; Chapman, Karen B.; Morin, Gregg B.; Harley, Calvin B.; Andrews, William H., Increasing the proliferative capacity of cells using telomerase reverse transcriptase.
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  24. Karas,Michael, Intracellular delivery of small molecules, proteins, and nucleic acids.
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  25. Karas,Michael, Intracellular delivery of small molecules, proteins, and nucleic acids.
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  26. Cech, Thomas R.; Lingner, Joachim; Nakamura, Toru M.; Chapman, Karen B.; Morin, Gregg B.; Harley, Calvin B.; Andrews, William H., Kit for detection of telomerase reverse transcriptase nucleic acids.
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  27. Cech,Thomas R.; Lingner,Joachim; Nakamura,Toru; Chapman,Karen B.; Morin,Gregg B.; Harley,Calvin B.; Andrews,William H., Mammalian cells that have increased proliferative capacity.
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  28. Cech, Thomas R.; Lingner, Joachim; Nakamura, Toru; Chapman, Karen B.; Morin, Gregg B.; Harley, Calvin; Andrews, William H., Method for detecting polynucleotides encoding telomerase.
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  29. Cech, Thomas R.; Lingner, Joachim; Nakamura, Toru M.; Chapman, Karen B.; Morin, Gregg B.; Harley, Calvin B.; Andrews, William H., Method for eliciting an immune response to human telomerase reverse transcriptase.
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  30. Harley, Calvin B.; Elias, Laurence; Smith, Jennifer; Ratain, Mark J.; Benedetti, Fabio, Method for identification of sensitivity of a patient to telomerase inhibition therapy.
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  31. Harley, Calvin B.; Elias, Laurence; Smith, Jennifer; Ratain, Mark J.; Benedetti, Fabio, Method for identification of sensitivity of a patient to telomerase inhibition therapy.
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  32. Gaeta,Federico C. A., Method for identifying and killing cancer cells.
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  33. Yang, Dan; Li, Xiang; Shen, Bing; Yao, Xiao-Qiang, Method of modulating membrane potential of a cell.
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  35. Weinrich, Scott L.; Atkinson, III, Edward M.; Lichtsteiner, Serge P.; Vasserot, Alain P.; Pruzan, Ronald A., Methods for purifying telomerase.
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  37. Cech, Thomas R.; Lingner, Joachim; Nakamura, Toru; Chapman, Karen B.; Morin, Gregg B.; Harley, Calvin B.; Andrews, William H., Muteins of human telomerase reverse transcriptase lacking telomerase catalytic activity.
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  38. Cech, Thomas R.; Lingner, Joachim; Nakamura, Toru; Chapman, Karen B.; Morin, Gregg B.; Harley, Calvin B.; Andrews, William H., Nucleic acid compositions for eliciting an immune response against telomerase reverse transcriptase.
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  39. Cech,Thomas R.; Lingner,Joachim; Nakamura,Toru; Chapman,Karen B.; Morin,Gregg B.; Harley,Calvin B.; Andrews,William H., Nucleic acids encoding human telomerase reverse transcriptase and related homologs.
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  40. Morin, Gregg B., Nucleic acids encoding inactive variants of human telomerase.
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  41. Gryaznov, Sergei M.; Pongracz, Krisztina; Tolman, Richard L.; Morin, Gregg B., Oligonucleotide conjugates.
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  42. Gryaznov, Sergei M.; Pongracz, Krisztina; Tolman, Richard L.; Morin, Gregg B., Oligonucleotide conjugates.
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  44. Gryaznov, Sergei; Pongracz, Krisztina; Tolman, Richard L.; Morin, Gregg B., Oligonucleotide conjugates.
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  45. Harrington,Lea Anne; Robinson,Murray O., Polynucleotides encoding a telomerase component TP2.
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  46. Xu, Chunhui; Gold, Joseph D., Process for making transplantable cardiomyocytes from human embryonic stem cells.
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  47. Morin, Gregg B.; Andrews, William H., Promoter for telomerase reverse transcriptase.
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  49. Wu, Min; Kuperwasser, Charlotte; Robinson, Murray, Reconstituted human breast tumor model.
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  51. Morin, Gregg B.; Andrews, William H., Regulatory segments of the human gene for telomerase reverse transcriptase.
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  52. Morin,Gregg B.; Andrews,William H., Regulatory segments of the human gene for telomerase reverse transcriptase.
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  53. Yang, Dan; Li, Xiang, Synthetic ion channels.
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  54. Shogbon, Christopher Bankole; Zhou, Yue; Brandenberger, Ralph, Synthetic surfaces for culturing stem cell derived cardiomyocytes.
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  57. Cech, Thomas R.; Lingner, Joachim; Nakamura, Toru; Chapman, Karen B.; Morin, Gregg B.; Harley, Calvin B.; Andrews, William H., Telomerase.
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  58. Cech,Thomas R.; Lingner,Joachim; Nakamura,Toru; Chapman,Karen B.; Morin,Gregg B.; Harley,Calvin B.; Andrews,William H., Telomerase.
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  59. Goldman,Steven A.; Roy,Neeta Singh, Telomerase immortalized neural progenitor cells.
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  62. Clark,A. John; Cui,Wei; Denning,Chris; Zhao,Debbiao, Telomerizing nuclear donor cells and improving the efficiency on nuclear transfer.
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  63. Cech,Thomas R.; Lingner,Joachim; Nakamura,Toru; Chapman,Karen B.; Morin,Gregg B.; Harley,Calvin B.; Andrews,William H., Treating cancer using a telomerase vaccine.
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  65. Tressler, Robert J.; Go, Ning F., Treatment of carcinomas with a combination of EGF-pathway and telomerase inhibitors.
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  67. Kilian, Andrzej; Bowtell, David, Vertebrate telomerase genes and proteins and uses thereof.
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