초록 ▼

A transdermal device is described suitable for delivery of a pharmaceutical to the systemic circulation through de-epithelialized skin. In its various embodiments the device includes means to prevent the attack of any protein or polypeptide active agent included therein by proteolytic enzymes which

A transdermal device is described suitable for delivery of a pharmaceutical to the systemic circulation through de-epithelialized skin. In its various embodiments the device includes means to prevent the attack of any protein or polypeptide active agent included therein by proteolytic enzymes which exude from the lesion, means to prevent the ingress of bacteria and other cellular debris from the lesion and means to ensure that substantially all said active agent is directed to the de-epithelialized lesion.

대표청구항 ▼

[ What is claimed is:] [1.]1. A transdermal device suitable for administration of a pharmaceutically active agent to the systemic circulation through a de-epithelialized skin lesion, said device including a reservoir for the active agent, said reservoir being selected from the group consisting of an

[ What is claimed is:] [1.]1. A transdermal device suitable for administration of a pharmaceutically active agent to the systemic circulation through a de-epithelialized skin lesion, said device including a reservoir for the active agent, said reservoir being selected from the group consisting of an inert porous matrix in which the active agent is dispersed and a chamber containing said agent in a form selected from the group consisting of a solid, an unsaturated solution, a saturated solution, a supersaturated solution and a suspension, said device further including a selective membrane positioned intermediate said reservoir and said de-epithelialized skin so as to be in contact with said de-epithelialized skin when the device is in use, said selective membrane having pores sized so as to block passage of proteolytic enzymes that exude from the de-epithelialized skin while permitting passage of active agent to the skin;wherein said selective membrane is cellulose acetate, nitrocellulose, polytetrafluoroethylene, or a swellable hydrogel.