초록 ▼

The invention provides compositions comprising microspheres of fibrinogen-coated cross-linked albumin microspheres having a size range of primarily from about 100 to about 5000 nanometers diameter, wherein the composition is substantially free microspheres and microsphere aggregates having a diamete

The invention provides compositions comprising microspheres of fibrinogen-coated cross-linked albumin microspheres having a size range of primarily from about 100 to about 5000 nanometers diameter, wherein the composition is substantially free microspheres and microsphere aggregates having a diameter of more than 10 micrometers. At least a portion of the fibrinogen on the surface of the microspheres is covalently attached. The particles of the invention are useful for reducing bleeding time when administered to a human or other animal.

대표청구항 ▼

[ What is claimed is:] [1.]1. A suspension of fibrinogen-coated cross-linked protein microspheres useful for reducing bleeding time in an animal with a platelet deficiency or dysfunction, said suspension comprising microspheres of cross-linked protein, said microspheres being monodisperse in said su

[ What is claimed is:] [1.]1. A suspension of fibrinogen-coated cross-linked protein microspheres useful for reducing bleeding time in an animal with a platelet deficiency or dysfunction, said suspension comprising microspheres of cross-linked protein, said microspheres being monodisperse in said suspension, having internal structure with fenestrations on the surface leading to internal matrices, and having a size range of primarily from abotut 100 to about 5000 nanometers diameter, said microspheres further comprising on their surface fibrinogen, wherein at least a portion of said fibrinogen is covalently bound to the protein, and wherein said suspension is substantially free of microspheres and microsphere aggregates having a diameter of more than 7 micrometers.