초록 ▼

Compositions, devices, and methods for transdermal administration of a drug are disclosed using a novel permeation enhancer mixture comprising a monoglyceride and ethyl palmitate. The monoglyceride/ethyl palmitate permeation enhancer is a potent permeation enhancer and provides stable systems which

Compositions, devices, and methods for transdermal administration of a drug are disclosed using a novel permeation enhancer mixture comprising a monoglyceride and ethyl palmitate. The monoglyceride/ethyl palmitate permeation enhancer is a potent permeation enhancer and provides stable systems which are more readily characterized. Additionally, ethyl palmitate cosolvent systems are more readily processed at manufacturing conditions thus providing further advantages over other cosolvents.

대표청구항 ▼

[ What is claimed is:] [1.]1. A composition of matter for transdermally delivering at least one drug at a therapeutically effective rate by permeation through a body surface or membrane comprising, in combination:(a) at least one drug; and(b) a permeation-enhancing amount of a permeation enhancer co

[ What is claimed is:] [1.]1. A composition of matter for transdermally delivering at least one drug at a therapeutically effective rate by permeation through a body surface or membrane comprising, in combination:(a) at least one drug; and(b) a permeation-enhancing amount of a permeation enhancer comprising 1-50% by weight of a monoglyceride and 1-50% by weight ethyl palmitate, wherein the drug and permeation enhancer are dispersed within a carrier.