[특허]Electrospray for chemical analysis

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	H01J-049/10
출원번호	US-0191866 (1998-11-12)
발명자 / 주소	Sheehan Edward W. Willoughby Ross C. Jarrell Joseph A. Strand David M.
출원인 / 주소	Waters Investments Limited
대리인 / 주소	Lee
인용정보	피인용 횟수 : 47 인용 특허 : 23

초록 ▼

An improved electrospray (ES) apparatus has a low pressure ES chamber coupled to a desolvation chamber. The desolvation chamber desolvates the incoming analyte ions of the cone-jet with non-conductive energy. The apparatus stabilizes cone-jet formation in the ES chamber. The apparatus receives solva

An improved electrospray (ES) apparatus has a low pressure ES chamber coupled to a desolvation chamber. The desolvation chamber desolvates the incoming analyte ions of the cone-jet with non-conductive energy. The apparatus stabilizes cone-jet formation in the ES chamber. The apparatus receives solvated ions without pressure reduction, produces desolvated ions with non-conductive energy in a low pressure region, and outputs the desolvated ions towards a mass spectrometer as a substantially solvent-free ion beam suitable for mass spectrometer analysis. The apparatus avoids the degree of pressure reduction featured in prior ES techniques.

대표청구항 ▼

[ What is claimed is:] [1.]1. An apparatus for producing desolvated analyte ions for a mass spectrometer, the apparatus comprising:an electrospray unit receiving a liquid sample comprising analyte and discharging said analyte as a cone-jet, said electrospray unit comprising an electrospray unit hous

[ What is claimed is:] [1.]1. An apparatus for producing desolvated analyte ions for a mass spectrometer, the apparatus comprising:an electrospray unit receiving a liquid sample comprising analyte and discharging said analyte as a cone-jet, said electrospray unit comprising an electrospray unit housing defining a pressure region below atmospheric pressure and a desolvation unit receiving said cone-jet and outputting desolvated analyte ions produced in said desolvation unit to said mass spectrometer, wherein said electrospray unit includes:a) a capillary means for introducing a liquid sample;b) a first chamber for receiving said liquid sample, said chamber including at least a first wall in which said capillary means is situated and at least a second wall, said chamber being maintained at a pressure substantially less than atmospheric pressure;c) a means for maintaining a high electric potential difference between said liquid sample within the capillary means and said second wall, whereby the surface of said liquid sample is distorted at the outlet of said capillary means into a single electrospray cone-jet;d) a heating means for heating the liquid sample within the capillary means to prevent the freezing of electrospray cone-jet exiting said outlet of capillary means; ande) an aperture disposed in said second wall of said first chamber so that the liquid jet and any resulting highly charged droplets from the breakup of the liquid jet are emitted from said first chamber; wherein said desolvation unit includes:f) a second chamber adjacent to said first chamber maintained at a pressure substantially less than atmospheric pressure and at a higher pressure than that of said first chamber, said second chamber includes said second wall of said first chamber, said aperture through which sample is emitted; and in which said liquid sample and analyte evaporate into a gas phase so that the analyte may be received by a detection device; andg) a heating means for heating said second chamber to facilitate the evaporation of said highly charged droplets.

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