[특허]Multiplex flow assays preferably with magnetic particles as solid phase

[미국특허] Multiplex flow assays preferably with magnetic particles as solid phase 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	B01D-035/06
출원번호	US-0302920 (1999-04-30)
발명자 / 주소	Watkins Michael I. Edwards Richard B.
출원인 / 주소	Bio-Rad Laboratories, Inc.
대리인 / 주소	Townsend and Townsend and Crew LLP
인용정보	피인용 횟수 : 51 인용 특허 : 5

초록 ▼

Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The particles are distinguishable from each other by characteristics that permit them to be differentiated into groups, each group carrying an assay reagent bonded to the particle surface that is distinct from the assay reagents of particles in other groups. The magnetic particles facilitate separation of the solid and liquid phases, permitting the assays to be performed by automated equipment. Assays are also disclosed for the simultaneous detection of antibodies of different classes and a common antigen specificity or of a common class and different antigen specificities. Each type is accomplished by immunological binding at the surfaces of two distinct solid phases in a sequential manner with dissociation of the binding and washing of the solid phase in between the binding steps.

대표청구항 ▼

[ We claim:] [1.]1. A method for individually detecting a plurality of analytes in a single fluid biological sample by assays that include the binding of said analytes in said biological sample to a solid phase that is in contact with a liquid medium in which said solid phase is insoluble, the separation of said solid phase from said liquid medium, said method comprising:using as said solid phase a plurality of microparticles of magnetically responsive material each with an assay reagent coupled thereto that is selectively active in an assay for one of said analytes, said microparticles classifiable into groups differing by the value of a selected differentiation parameter whose value is detectable, each group distinguishable from other groups by the value of said parameter and by the assay reagent coupled to the microparticles of said group;magnetically separating microparticles in all of said groups from said liquid medium; anddefining said liquid medium as a first liquid medium, resuspending said microparticles separated therefrom in a second liquid medium, analyzing said microparticles in said second liquid medium by flow cytometry in accordance with both the value of said selected differentiation parameter and said plurality of assays, thereby achieving individual detection of said analytes in said biological sample.

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[미국특허] Multiplex flow assays preferably with magnetic particles as solid phase 원문보기

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[미국특허] Multiplex flow assays preferably with magnetic particles as solid phase 원문보기

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이 특허에 인용된 특허 (5) 인용/피인용 타임라인 분석

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