초록 ▼

The present invention generally relates to miniaturized devices for carrying out and controlling chemical reactions and analyses. In particular, the present invention provides devices which have miniature temperature controlled reaction chambers for carrying out a variety of synthetic and diagnostic

The present invention generally relates to miniaturized devices for carrying out and controlling chemical reactions and analyses. In particular, the present invention provides devices which have miniature temperature controlled reaction chambers for carrying out a variety of synthetic and diagnostic applications, such as PCR amplification, nucleic acid hybridization, chemical labeling, nucleic acid fragmentation and the like.

대표청구항 ▼

[ What is claimed is:] [10.]10. A miniature reaction system comprising:a body having a cavity disposed therein;a heater deposited within said cavity, said heater being electrically connected to a power source;a temperature sensor in thermal contact with said cavity;an appropriately programmed comput

[ What is claimed is:] [10.]10. A miniature reaction system comprising:a body having a cavity disposed therein;a heater deposited within said cavity, said heater being electrically connected to a power source;a temperature sensor in thermal contact with said cavity;an appropriately programmed computer for monitoring said temperature and controlling said power source; anda microcapillary gel electrophoresis device comprising a first gel filled microcapillary extending from the cavity, and a second gel filled microcapillary intersecting across the first gel filled microcapillary, the second gel filled microcapillary being in fluid communication with the first gel filled microcapillary, said second gel filled microcapillary comprising an electrophoretic channel. [11.]11. A miniature reaction system comprising:a body having a cavity disposed therein;a heater deposited within said cavity, said heater being electrically connected to a power source;a temperature sensor in thermal contact with said cavity;an appropriately programmed computer for monitoring said temperature and controlling said power source;a gel filled microcapillary extending from the cavity; anda reaction chamber in fluid communication with the gel filled microcapillary, the reaction chamber having a nucleic acid array disposed therein, said nucleic acid array including a substrate having a plurality of positionally distinct nucleic acid probes coupled to a surface of said substrate.