초록

The microcapsules that are produced with this process do not show any tendency toward agglomeration. The encapsulation efficiency of the process is approximately 90 to 95%.

대표청구항 ▼

[ What is claimed is:] [1.]1. A process for the production of morphologically uniform microcapsules consisting of:forming a polymer solution by dissolving a polymer selected from the group consisting of polyamides, polyanhydrides, polyorthoesters, polyacetates, polylactones, polyorthocarbonates, and

[ What is claimed is:] [1.]1. A process for the production of morphologically uniform microcapsules consisting of:forming a polymer solution by dissolving a polymer selected from the group consisting of polyamides, polyanhydrides, polyorthoesters, polyacetates, polylactones, polyorthocarbonates, and polyesters, in a partially water-miscible halogen-free solvent or partially water-miscible halogen-free solvent mixture;adding a solution of a water-soluble active agent to the polymer solution to form a polymer/active agent dispersion; adding an aqueous solution containing a surfactant to the polymer/active agent dispersion thereby providing a final total volume wherein the polymer/active agent dispersion is present in the total volume in an amount less than 50% v/v, and the surfactant solution is present in the total volume in an amount less than 60% v/v; andremoving the solvent to produce microcapsules having a concentration of drug of less than 30% w/w.