초록 ▼

Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data char

Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.

대표청구항 ▼

[ What is claimed is:] [1.]1. A device for implantation in a mammal, comprising:a biocompatible particulate matrix, the matrix comprising collagen and at least one material selected from the group consisting of polymers comprising lactic acid monomer units, polymers comprising glycolic acid monomer

[ What is claimed is:] [1.]1. A device for implantation in a mammal, comprising:a biocompatible particulate matrix, the matrix comprising collagen and at least one material selected from the group consisting of polymers comprising lactic acid monomer units, polymers comprising glycolic acid monomer units, bone, hydroxyapatite, calcium phosphate, muscle, and tissue; anda substantially pure osteogenic or chondrogenic protein disposed in or on said matrix, wherein said protein induces the influx, proliferation, and differentiation of migratory precursor cells from the body of said mammal into or on said matrix.