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Drug delivery system involving interaction between protein or polypeptide and hydrophobic biodegradable polymer 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/00
  • A61K-009/50
출원번호 US-0481155 (1995-06-07)
발명자 / 주소
  • Deluca Patrick P.
출원인 / 주소
  • University of Kentucky Research Foundation
대리인 / 주소
    Burns, Doane, Swecker & Mathis, LLP
인용정보 피인용 횟수 : 17  인용 특허 : 20

초록 ▼

A drug delivery system for controlled release of a protein or polypeptide comprising a hydrophobic biodegradable polymer and a protein or polypeptide. A physical interaction is present between the polymer and the protein or polypeptide, thus, allowing protection and controlled release of the protein

대표청구항 ▼

[ What is claimed is:] [1.]1. A drug delivery system for controlled release of calcitonin, said delivery system comprising a biodegradable hydrophobic polymer selected from the group consisting of polyglycolic acid, polylactic acid, copolymers of glycolic acid and L- or D,L-lactic acid, and copolyme

이 특허에 인용된 특허 (20)

  1. Kohn Joachim B. (Highland Park NJ) Langer Robert S. (Somerville MA) Niemi Steven M. (Sudbury MA) Fox James G. (Littleton MA), Biodegradable polymeric drug delivery system with adjuvant activity.
    상세보기
  2. Hutchinson Francis G. (Lymm GBX), Continuous release pharmaceutical compositions.
    상세보기
  3. Hutchinson Francis G. (Lymm GBX), Continuous release pharmaceutical compositions formed by freeze drying acetic acid solutions of polylactide.
    상세보기
  4. Eppstein Deborah A. (Palo Alto CA) Schryver Brian B. (Redwood City CA), Controlled release of macromolecular polypeptides.
    상세보기
  5. Cioca Gheorghe (Coatesville PA), Cosmetic and pharmaceutical sheet material containing polypeptides.
    상세보기
  6. Cioca Gheorghe (Coatesville PA), Cosmetic and pharmaceutical sheet material containing polypeptides.
    상세보기
  7. Vieth Wolf R. (Belle Mead NJ) Wang Shaw S. (N. Brunswick NJ) Gilbert Seymour G. (Piscataway NJ), Enzymatically active protein-enzyme complex membranes.
    상세보기
  8. Heckmann Klaus (Zum Aichahof 20 D-8400 Regensburg DEX) Manecke Georg (Berlin DEX) Pfannenmller Beate (Freiburg DEX) Ring Klaus (Frankfurt DEX) Ringsdorf Helmut (Mainz DEX), Hyperfiltration membranes having separation layers of monomolecular films of surfactants.
    상세보기
  9. Brynes Paul J. (Libertyville IL) Andrade-Gordon Patricia (Port Jefferson NY), Immobilized fluorogenic substrates for enzymes; and processes for their preparation.
    상세보기
  10. Cahn Frederick (57 Raleigh Rd. Belmont MA 02178), Immunostimulatory microsphere.
    상세보기
  11. Longo William E. (Gainesville FL) McCluskey Richard A. (Gainesville FL) Goldberg Eugene P. (Gainesville FL), Magnetically responsive, hydrophilic microspheres for incorporation of therapeutic substances and methods of preparation.
    상세보기
  12. Domb Abraham J. (Brookline MA) Langer Robert S. (Somerville MA), Polyanhydrides with improved hydrolytic degradation properties.
    상세보기
  13. DeLuca Patrick P. (Lexington KY) Kanke Motoko (Fukuyama JPX) Sato Toyomi (Tokyo CA JPX) Schroeder Hans G. (Encinitas CA), Porous microspheres for drug delivery and methods for making same.
    상세보기
  14. De Luca Patrick P. (Lexington KY) Rypacek Frantisek (Leckova CZX), Preparation of biodegradable microspheres useful as carriers for macromolecules.
    상세보기
  15. Vieth Wolf R. (Belle Mead NJ) Wang Shaw S. (Somerset NJ) Saini Rakesh (New Brunswick NJ), Preparation of protein membranes containing microbial cells.
    상세보기
  16. Heckmann Klaus (Regensburg DEX) Manecke Georg (Berlin DEX) Pfannenmller Beate (Frieburg DEX) Ring Klaus (Frankfurt DEX) Ringsdorf Helmut (Mainz DEX), Process for the production of hyperfiltration membranes.
    상세보기
  17. Vieth Wolf R. (Belle Mead NJ) Wang Shaw S. (North Brunswick NJ) Gilbert Seymour G. (Piscataway NJ), Protein-enzyme complex membranes.
    상세보기
  18. Cioca, Gheorghe; Siegler, Marcel; Spiliadis, Apostol, Surface active agent compositions.
    상세보기
  19. Cioca Gheorghe (Coatesville PA) Siegler Marcel (North Bergen NJ) Spiliadis Apostol (Frazer PA), Surface active agent compositions containing polypeptides and lignin sulfonic acid.
    상세보기
  20. Gombotz Wayne R. (Lexington MA) Healy Michael S. (E. Bridgewater MA) Brown Larry R. (Newton MA), Very low temperature casting of controlled release microspheres.
    상세보기

이 특허를 인용한 특허 (17)

  1. Tiwari, Deepak; Owoo, George; Nayak, Rekha; Burhop, Kenneth E., Colored esmolol concentrate.
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  2. Kipp,James E.; Doty,Mark J.; Rebbeck,Christine L.; Brynjelsen,Sean; Konkel,Jamie Teresa, Compositions of and method for preparing stable particles in a frozen aqueous matrix.
    상세보기
  3. Southard, Jeffrey L.; Southard, George L., Controlled release CGRP delivery composition for cardiovascular and renal indications.
    상세보기
  4. Basu, Joydeep; Payne, Richard; Robbins, Neil F.; Knight, Oluwatoyin A.; Jain, Deepak; Halberstadt, Craig R.; Serban, Monica A., Injectable formulations for organ augmentation.
    상세보기
  5. Ho, Mei-Ling; Wang, Gwo-Jaw; Chang, Je-Ken; Fu, Yin-Chih; Tzeng, Cherng-Chyi; Rajalakshmanan, Eswaramoorthy, Method for controlled release of parathyroid hormone from encapsulated poly(lactic-glycolic)acid microspheres.
    상세보기
  6. Kipp, James E.; Wong, Joseph Chung Tak; Doty, Mark J.; Werling, Jane; Rebbeck, Christine L.; Brynjelsen, Sean, Method for preparing submicron particle suspensions.
    상세보기
  7. Chaubal, Mahesh; Werling, Jane; Rabinow, Barrett, Method for preparing submicron particles of antineoplastic agents.
    상세보기
  8. Werling, Jane; Kipp, James E.; Sriram, Rajaram; Doty, Mark J., Method for preparing submicron suspensions with polymorph control.
    상세보기
  9. Rabinow, Barrett; White, Randy; Sun, Chong-Son; Wong, Joseph Chung Take; Kipp, James E.; Doty, Mark; Rebbeck, Christine L.; Papadopoulos, Pavlos, Method for treating infectious organisms normally considered to be resistant to an antimicrobial drug.
    상세보기
  10. Kipp, James E.; Wong, Joseph Chung Tak; Doty, Mark J.; Rebbeck, Christine L., Microprecipitation method for preparing submicron suspensions.
    상세보기
  11. Kipp, James E.; Wong, Joseph Chung Tak; Doty, Mark J.; Rebbeck, Christine L.; Brynjelsen, Sean, Microprecipitation method for preparing submicron suspensions.
    상세보기
  12. Kipp,James E.; Wong,Joseph Chung Tak; Doty,Mark J.; Rebbeck,Christine L., Microprecipitation method for preparing submicron suspensions.
    상세보기
  13. Tiwari, Deepak; Owoo, George; Nayak, Rekha; Burhop, Kenneth E., Multi-dose concentrate esmolol with benzyl alcohol.
    상세보기
  14. Werling,Jane; Doty,Mark J.; Rebbeck,Christine L.; Wong,Joseph Chung Tak; Kipp,James E., Polymorphic form of itraconazole.
    상세보기
  15. Brynjelsen, Sean; Doty, Mark; Kipp, James E.; Jayswal, Nailesh; Narayanan, Krishnaswamy, Preparation of submicron sized nanoparticles via dispersion lyophilization.
    상세보기
  16. Brynjelsen, Sean; Doty, Mark; Kipp, James E.; Jayswal, Nailesh; Narayanan, Krishnaswamy, Preparation of submicron sized nanoparticles via dispersion lyophilization.
    상세보기
  17. Chaubal, Mahesh; Doty, Mark J.; Konkel, Jamie T.; Rabinow, Barrett E., Surfactant systems for delivery of organic compounds.
    상세보기

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