초록 ▼

Disclosed is a novel tissue adhesive technology comprising a combination of ultrasonically treated proteins including collagen and albumin which form a viscous material that develops adhesive properties when chemically cross-linked. A novel new cross-linking agent with surprisingly stable properties

Disclosed is a novel tissue adhesive technology comprising a combination of ultrasonically treated proteins including collagen and albumin which form a viscous material that develops adhesive properties when chemically cross-linked. A novel new cross-linking agent with surprisingly stable properties was developed in association with the tissue adhesive described and claimed herein and is considered to be within the scope of the present invention. This new cross-linking agent is a product of reacting glutaraldehyde with amino acids or peptides and allowing the reaction to proceed to completion. This chemical cross-linker is mixed with the ultrasonically treated proteins, allowed to react for a pre-determined time, then used to seal large surface areas of vigorously bleeding tissues including, but not limited to, the liver, lungs and major vascular systems in patients with and without bleeding disorders. This same tissue adhesive has proven to work well in sealing suture sites to prevent leakage.

대표청구항 ▼

[ I claim:] [1.]1. A tissue adhesive for controlling vigorously bleeding tissues comprising:at least one fibrous protein;at least one globular protein; andat least one cross-linking agent; whereinsaid at least one fibrous protein and said at least one globular protein are ultrasonically treated prio

[ I claim:] [1.]1. A tissue adhesive for controlling vigorously bleeding tissues comprising:at least one fibrous protein;at least one globular protein; andat least one cross-linking agent; whereinsaid at least one fibrous protein and said at least one globular protein are ultrasonically treated prior to application to a mammalian tissue in need thereof.