초록 ▼

The present invention provides an improved method of removing fluids, gases or other biomolecules, or delivering a pharmaceutical composition, through the skin of a patient without the use of a sharp or needle. The method includes the step of irradiating the stratum corneum, an applied pharmaceutica

The present invention provides an improved method of removing fluids, gases or other biomolecules, or delivering a pharmaceutical composition, through the skin of a patient without the use of a sharp or needle. The method includes the step of irradiating the stratum corneum, an applied pharmaceutical or an absorbing material, using a laser. By selection of parameters, the laser irradiates the selected material or tissue to create pressure gradients, plasma, cavitation bubbles, or other forms of tissue ablation or alteration. These methods increase the diffusion of pharmaceuticals into, or fluids, gases or other biomolecules out of, the body. For this invention, a pharmaceutical composition can be applied to the skin before or after laser irradiation.

대표청구항 ▼

[ We claim:] [1.]1. A method for preparing the skin for treatment of cutaneous or subcutaneous compounds, comprising the steps of:a) focusing a laser beam with sufficient energy fluence to alter the skin at least as deep as the stratum corneum, but not as deep as the capillary layer;b) firing the la

[ We claim:] [1.]1. A method for preparing the skin for treatment of cutaneous or subcutaneous compounds, comprising the steps of:a) focusing a laser beam with sufficient energy fluence to alter the skin at least as deep as the stratum corneum, but not as deep as the capillary layer;b) firing the laser to create a site of alteration, the site having a diameter of between 0.5 microns and 5.0 cm;c) applying a dye, a compound that alters the optical properties of stratum corneum, or a compound that stimulates the body's production of molecules that are strong absorbers of light; andd) firing a second laser with a wavelength that is absorbed by the applied dye, the compound that stimulates the optical properties of stratum corneum or the compound that stimulates the body's production of molecules that are strong absorbers of light.