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Methods and integrated devices and systems for performing temperature controlled reactions and analyses 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • G01N-001/00
  • C12P-019/34
출원번호 US-0705065 (2000-11-02)
발명자 / 주소
  • Robert Nagle
  • Robert S. Dubrow
출원인 / 주소
  • Caliper Technologies Corp.
대리인 / 주소
    Matthew B. Murphy
인용정보 피인용 횟수 : 14  인용 특허 : 28

초록

Reactor systems that include a reaction receptacle that includes a plurality of reservoirs disposed in the surface of a substrate. The reactor system also typically includes a temperature control element having at least a first heat exchanger thermally coupled to it. The heat exchanger is, in turn,

대표청구항

1. A method of performing temperature dependent reactions, comprising:providing a reactor system, which comprises a plurality of reservoirs disposed in a body structure, the reservoirs being fluidly connected to a microscale channel network disposed in an interior portion of the body structure, a te

이 특허에 인용된 특허 (28)

  1. Takatsy ; Gyula ; Barb ; Katalin ; Muranyi ; Istvan ; Burda ; Ferencne, Apparatus for and a method of the determination of influenza neuraminidase.
  2. Parce John Wallace ; Knapp Michael R. ; Chow Calvin Y. H. ; Bousse Luc, Controlled fluid transport in microfabricated polymeric substrates.
  3. Chow Calvin Y. H. ; Parce John Wallace ; McReynolds Richard J. ; Kennedy Colin B. ; Bousse Luc J., Controller/detector interfaces for microfluidic systems.
  4. Parce J. Wallace ; Knapp Michael R., Electropipettor and compensation means for electrophoretic bias.
  5. Parce J. Wallace ; Knapp Michael R., Electropipettor and compensation means for electrophoretic bias.
  6. Wilding Peter (Paoli PA) Kricka Larry J. (Berwyn PA) Zemel Jay N. (Jenkintown PA), Fluid handling methods for use in mesoscale analytical devices.
  7. Parce J. Wallace, Fourier detection of species migrating in a microchannel.
  8. Parce J. Wallace (Palo Alto CA), Fourier detection of species migrating in a microchannel.
  9. Swedberg Sally A. (Los Altos CA) Kaltenbach Patrick (Bischweier DEX) Witt Klaus E. (Keltern DEX) Bek Fritz (Waldbronn DEX) Mittelstadt Laurie S. (Belmont CA), Fully integrated miniaturized planar liquid sample handling and analysis device.
  10. Atwood John G. (West Redding CT) Haff Lawrence A. (Wilton CT), In situ PCR amplification system.
  11. Wilding Peter (Paoli PA) Kricka Larry J. (Berwyn PA), Mesoscale polynucleotide amplification device and method.
  12. Batchelder J. Samuel (85 Allison Rd. Katonah NY 10536), Method and apparatus for dielectrophoretic manipulation of chemical species.
  13. Bertling Wolf,DEX, Method and apparatus for processing nucleic acids using a small temperature-changing zone.
  14. Soane David S. (Piedmont CA) Soane Zoya M. (Piedmont CA), Method and device for moving molecules by the application of a plurality of electrical fields.
  15. Soane David S. ; Soane Zoya M., Method and device for moving molecules by the application of a plurality of electrical fields.
  16. Cherukuri Satyam C. (Cranbury NJ) Demers Robert R. (Cranbury NJ) Fan Zhong H. (Middlesex NJ) Levine Aaron W. (Lawrenceville NJ) McBride Sterling E. (Lawrence Township ; Mercer County NJ) Zanzucchi Pe, Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device.
  17. McReynolds Richard J., Method of manufacturing microfluidic devices.
  18. Parce John Wallace ; Kopf-Sill Anne R., Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems.
  19. Wilding Peter (Paoli PA) Kricka Larry J. (Berwyn PA) Zemel Jay N. (Jenkintown PA), Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems.
  20. Kennedy Colin B., Microfluidic devices and systems.
  21. Kopf-Sill Anne R. ; Parce John Wallace, Microfluidic systems incorporating varied channel dimensions.
  22. Kroy Walter (Ottobrunn DEX) Seidel Helmut (Starnberg DEX) Dette Eduard (Vagen DEX) Koniger Max (Munich DEX) Deimel Peter (Langenpreising DEX) Binder Florian (Traunstein DEX) Hilpert Reinhold (Munich , Micromechanical structure.
  23. Zanzucchi Peter J. (Lawrenceville NJ) Cherukuri Satyam C. (Cranbury NJ) McBride Sterling E. (Lawrenceville NJ), Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis.
  24. Zanzucchi Peter J. (West Windsor Township NJ) Cherukuri Satyam C. (Cranbury NJ) McBride Sterling E. (Lawrence Township NJ) Judd Amrit K. (Belmont CA), Partitioned microelectronic device array.
  25. Pace Salvatore J. (Wilmington DE), Silicon semiconductor wafer for analyzing micronic biological samples.
  26. Macho Heinz,DEX ; Bienhaus Gerhard,DEX, System for the temperature adjustment treatment of liquid samples.
  27. Atwood John G. (West Redding CT) Mossa Albert C. (Trumbull CT) Goven Lisa M. (Bridgeport CT) Williams Fenton (Brookfield CT) Woudenberg Timothy M. (Bethel CT) Margoulies Marcel (Scarsdale NY) Ragusa , Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control.
  28. Chow Calvin Y. H. ; Parce J. Wallace, Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forc.

이 특허를 인용한 특허 (14)

  1. Marble, Herbert A.; Laffler, Thomas, Channels with cross-sectional thermal gradients.
  2. Marble, Herbert A.; Laffler, Thomas, Channels with cross-sectional thermal gradients.
  3. Kriz, Dario; Ljung, Christer, Device and method for performing a process in a process medium.
  4. Takahashi, Toru; Inoue, Hiroshi, Devices and methods for monitoring genomic DNA of organisms.
  5. Takahashi, Toru; Inoue, Hiroshi, Devices and methods for monitoring genomic DNA of organisms.
  6. Pollack, Michael G.; Pamula, Vamsee K.; Paik, Philip; Eckhardt, Allen, Droplet-based nucleic acid amplification in a temperature gradient.
  7. Turner, Allen, Heater block for pressure digestion vessels.
  8. Nagle, Robert; Dubrow, Robert S., Integrated devices and method of use for performing temperature controlled reactions and analyses.
  9. Takahashi, Toru; Boles, Deborah John, Methods for monitoring genomic DNA of organisms.
  10. Gandhi,Khushroo; Dubrow,Robert S.; Bousse,Luc J., Methods of fabricating polymeric structures incorporating microscale fluidic elements.
  11. Mahant, Vijay K.; Kureshy, Fareed; Singh, Shailendra, Multi-substrate biochip unit.
  12. Gandhi, Khushroo; Dubrow, Robert S.; Bousse, Luc J., Polymeric structures incorporating microscale fluidic elements.
  13. Ferguson,Lucian G., Tapecast electro-conductive cermets for high temperature resistive heating systems.
  14. Baumgardner, James E., Temperature controller for small fluid samples with different heat capacities.
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