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Stable complexes of poorly soluble compounds in ionic polymers 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-047/32
  • A61K-047/38
출원번호 US-0391060 (1999-09-07)
발명자 / 주소
  • Antonio A. Albano
  • Wantanee Phuapradit
  • Harpreet K. Sandhu
  • Navnit Hargovindas Shah
출원인 / 주소
  • Hoffmann-La Roche Inc.
대리인 / 주소
    George W. Johnston
인용정보 피인용 횟수 : 39  인용 특허 : 8

초록 ▼

Stable water-insoluble complexes of poorly soluble compounds molecularly dispersed in water-insoluble ionic polymers are disclosed. Useful insoluble ionic polymers have a molecular weight greater than about 80,000 D and a glass transition temperature equal to or greater than about 50.degree.. The co

대표청구항 ▼

1. A pharmaceutical composition comprising a carrier and a water-soluble complex of a therapeutically active, stable amorphous compound selected from the group consisting of [EQU3][EQU4]and a water-insoluble ionic polymer that has a molecular weight greater than about 80,000 D, a glass transition te

이 특허에 인용된 특허 (8)

  1. Bosies Elmar,DEX ; Esswein Angelika,DEX ; Grams Frank,DEX ; Krell Hans-Willi,DEX ; Menta Ernesto,ITX, Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds.
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  2. Chen Li ; Guthrie Robert William ; Huang Tai-Nang ; Sidduri Achyutharao ; Tilley Jefferson Wright ; Hull Kenneth Gregory, N-aroylphenylalanine derivative VCAM-1 inhibitors.
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  3. Kelm Gary R. (Cincinnati OH) Dobrozsi Douglas J. (Cincinnati OH), Solid dispersion compositions of tebufelone.
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  4. Davis Peter D.,GBX ; Hill Christopher H.,GBX ; Lawton Geoffrey,GBX, Substituted pyrroles.
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  5. Dhingra Urvashi Hooda ; Huryn Donna Mary ; Ke June ; Weber Giuseppe Federico, Substituted pyrroles.
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  6. Liversidge Gary G. (West Chester PA) Liversidge Elaine (West Chester PA) Sarpotdar Pramod P. (Malvern PA), Surface modified anticancer nanoparticles.
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  7. Martin Frederick H. (West Chazy NY) Tsuk Andrew G. (Plattsburgh NY), Therapeutic compositions with enhanced bioavailability.
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  8. Li Chun ; Wallace Sidney ; Yu Dong-Fang ; Yang David J., Water soluble paclitaxel prodrugs.
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이 특허를 인용한 특허 (39)

  1. Boruah, Anima; Alikunju, Shanavas, 5-benzylaminomethyl-6-aminopyrazolo [3, 4 -B] pyridine derivatives as cholesteryl ester-transfer protein (CETP) inhibitors useful for the treatment of atherosclerosis.
    상세보기
  2. Antonio A. Albano ; Wantanee Phuapradit ; Harpreet K. Sandhu ; Navnit Hargovindas Shah, Amorphous form of cell cycle inhibitor having improved solubility and bioavailability.
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  3. Antonio A. Albano ; Wantanee Phuapradit ; Harpreet K. Sandhu ; Navnit Hargovindas Shah, Amorphous form of cell cycle inhibitor having improved solubility and bioavailability.
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  4. Antonio A. Albano ; Wantanee Phuapradit ; Harpreet K. Sandhu ; Navnit Hargovindas Shah, Amorphous form of cell cycle inhibitor having improved solubility and bioavailability.
    상세보기
  5. Antonio A. Albano ; Wantanee Phuapradit ; Harpreet K. Sandhu ; Navnit Hargovindas Shah, Amorphous form of cell inhibitor having improved solubility and bioavailability.
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  6. Baruah, Anima; De, Dibyendu; Khanna, Ish Kumar; Pillarisetti, Sivaram; Maitra, Santanu; Alexander, Christopher W.; Sreenu, Jennepalli; Dager, Indu; Alikunju, Shanavas, Benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors.
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  7. Perry, David; Maples, Kirk R.; Bellinger-Kawahara, Carolyn, Boron-containing compounds and methods of use.
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  8. Desai, Dipen; Diodone, Ralph; Go, Zenaida; Ibrahim, Prabha N.; Iyer, Raman; Mair, Hans-Juergen; Sandhu, Harpreet K.; Shah, Navnit H.; Visor, Gary; Wyttenbach, Nicole; Lauper, Stephan; Pudewell, Johannes; Wierschem, Frank, Compositions and uses thereof.
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  9. Desai, Dipen; Diodone, Ralph; Go, Zenaida; Ibrahim, Prabha N.; Iyer, Raman; Mair, Hans-Juergen; Sandhu, Harpreet K.; Shah, Navnit H.; Visor, Gary; Wyttenbach, Nicole; Lauper, Stephan; Pudewell, Johannes; Wierschem, Frank, Compositions and uses thereof.
    상세보기
  10. Ibrahim, Prabha N.; Artis, Dean R.; Bremer, Ryan; Habets, Gaston; Mamo, Shumeye; Nespi, Marika; Zhang, Chao; Zhang, Jiazhong; Zhu, Yong-Liang; Zuckerman, Rebecca; West, Brian; Suzuki, Yoshisa; Tsai, Jianming; Hirth, Klaus-Peter; Bollag, Gideon; Spevak, Wayne; Cho, Hanna; Gillette, Samuel J.; Wu, Guoxian; Zhu, Hongyao; Shi, Shenghua, Compounds and methods for kinase modulation, and indications therefor.
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  11. Ibrahim, Prabha N.; Artis, Dean R.; Bremer, Ryan; Mamo, Shumeye; Zhang, Chao; Zhang, Jiazhong; Tsai, Jianming; Hirth, Klaus-Peter; Bollag, Gideon; Spevak, Wayne; Cho, Hanna; Gillette, Samuel J.; Shi, Shenghua, Compounds and methods for kinase modulation, and indications therefor.
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  12. Ibrahim, Prabha; Zhang, Chao; Spevak, Wayne; Zhang, Jiazhong; Wu, Guoxian; Lin, Jack; Cho, Hanna; Nespi, Marika; Shi, Songyuan; Ewing, Todd; Zhang, Ying, Compounds and methods for kinase modulation, and indications therefor.
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  13. Wu, Guoxian; Spevak, Wayne; Shi, Songyuan; Cho, Hanna; Ibrahim, Prabha N.; Zhang, Chao; Shi, Shenghua; Zhou, Yong; Artis, Dean; Zhang, Jiazhong, Compounds and methods for kinase modulation, and indications therefor.
    상세보기
  14. Wu, Guoxian; Zhang, Jiazhong; Zhu, Yong-Liang; Zhang, Chao; Ibrahim, Prabha N.; Shi, Songyuan; Spevak, Wayne; Artis, Dean R.; Tsai, James, Compounds and methods for kinase modulation, and indications therefor.
    상세보기
  15. Wu, Guoxian; Zhang, Jiazhong; Zhu, Yong-Liang; Zhang, Chao; Ibrahim, Prabha N.; Shi, Songyuan; Spevak, Wayne; Artis, Dean R.; Tsai, James, Compounds and methods for kinase modulation, and indications therefor.
    상세보기
  16. Zhang, Jiazhong; Ibrahim, Prabha N.; Bremer, Ryan; Spevak, Wayne; Cho, Hanna, Compounds and methods for kinase modulation, and indications therefor.
    상세보기
  17. Zhang, Jiazhong; Ibrahim, Prabha N.; Artis, Dean R.; Bremer, Ryan; Wu, Guoxian; Zhu, Hongyao; Nespi, Marika; Zhang, Chao, Compounds modulating c-fms and/or c-kit activity.
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  18. Ibrahim, Prabha N.; Artis, Dean R.; Bremer, Ryan; Wu, Guoxian; Zhu, Hongyao; Nespi, Marika; Zhang, Chao; Zhang, Jiazhong, Compounds modulating c-fms and/or c-kit activity and uses therefor.
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  19. Zhang, Jiazhong; Ibrahim, Prabha N.; Artis, Dean R.; Bremer, Ryan; Wu, Guoxian; Nespi, Marika; Zhang, Chao, Compounds modulating c-fms and/or c-kit activity and uses therefor.
    상세보기
  20. Zhang, Jiazhong; Ibrahim, Prabha N.; Bremer, Ryan, Compounds modulating c-fms and/or c-kit activity and uses therefor.
    상세보기
  21. Zhang, Jiazhong; Ibrahim, Prabha N.; Bremer, Ryan, Compounds modulating c-fms and/or c-kit activity and uses therefor.
    상세보기
  22. Naringrekar, Gandha V.; Arnold, Kristin A.; Erkoboni, David, Controlled-release formulations, method of manufacture, and use thereof.
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  23. Naringrekar, Gandha V.; Arnold, Kristin A.; Erkoboni, David, Controlled-release formulations, method of manufacture, and use thereof.
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  24. Breimer, Lars Holger; Dhingra, Kapil; Dhingra, Urvashi Hooda; Ritland, Steve, Method for cancer therapy.
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  25. Beyerinck, Ronald A.; Deibele, Heather L. M.; Dobry, Dan E.; Ray, Roderick J.; Settell, Dana M.; Spence, Ken R., Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus.
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  26. Beyerinck, Ronald A.; Diebele, Heather L. M.; Dobry, Dan E.; Ray, Roderick J.; Settell, Dana M.; Spence, Ken R., Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus.
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  27. Moolman, Francis Sean; Rolfes, Heidi; Van Der Merwe, Thilo Lothar, Method of encapsulating an active substance.
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  28. Djordjevic, Jelena; Bommana, Murali Mohan; Phuapradit, Wantanee; Shah, Navnit H.; Pizzo, Christopher A., Orally disintegrating tablet formulation for enhanced bioavailability.
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  29. Bartsch, Pierre; Cataldo, Didier; Endele, Richard; Evrard, Brigitte; Foidart, Jean-Michel; Krell, Hans-Willi; Zimmermann, Gerd, Pharmaceutical compositions of pyrimidine-2,4,6-triones.
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  30. Mehta, Deepak B.; Corbo, Michael, Process for coating stents and other medical devices using super-critical carbon dioxide.
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  31. Hildbrand, Stefan; Mair, Hans-Juergen; Radinov, Roumen Nikolaev; Ren, Yi; Wright, James Anderson, Process for the manufacture of pharmaceutically active compounds.
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  32. Kawasaki, Junichi; Nakamura, Atsuya; Kamada, Naoki, Solid dispersion comprising amorphous cilostazol.
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  33. Ibrahim, Prabha N.; Visor, Gary Conard; Kuang, Shan-Ming; Zhao, Baoshu; Diodone, Ralph; Fähnrich, Karsten; Schwitter, Urs, Solid forms of a pharmaceutically active substance.
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  34. Ibrahim, Prabha N.; Visor, Gary Conard; Kuang, Shan-Ming; Zhao, Baoshu; Diodone, Ralph; Fähnrich, Karsten; Schwitter, Urs, Solid forms of a pharmaceutically active substance.
    상세보기
  35. Baruah, Anima; De, Dibyendu; Khanna, Ish Kumar; Pillarisetti, Sivaram; Maitra, Santanu; Alexander, Christopher W.; Sreenu, Jennepalli; Dager, Indu; Alikunju, Shanavas, Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors.
    상세보기
  36. Baruah, Anima; De, Dibyendu; Khanna, Ish Kumar; Pillarisetti, Sivaram; Maitra, Santanu; Alexander, Christopher W.; Sreenu, Jennepalli; Dager, Indu; Alikunju, Shanavas, Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors.
    상세보기
  37. Boruah, Anima; Alikunju, Shanavas, Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (CETP) inhibitors.
    상세보기
  38. Ibrahim, Prabha N., Synthesis of heterocyclic compounds.
    상세보기
  39. Ibrahim, Prabha N., Synthesis of heterocyclic compounds.
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