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Bioadhesive microspheres and their use as drug delivery and imaging systems 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/14
출원번호 US-0773229 (2001-01-31)
발명자 / 주소
  • Edith Mathiowitz
  • Donald E. Chickering, III
  • Jules Serge Jacob
출원인 / 주소
  • Brown University Research Foundation
대리인 / 주소
    Holland & Knight LLP
인용정보 피인용 횟수 : 88  인용 특허 : 17

초록 ▼

Bioadhesive polymers in the form of, or as a coating on, microcapsules containing drugs or bioactive substances which may serve for therapeutic, or diagnostic purposes in diseases of the gastrointestinal tract, are described. The polymeric microspheres all have a bioadhesive force of at least 11 mN/

대표청구항 ▼

1. A drug formulation comprising drug encapsulated within a microsphere having a polymeric surface with an adhesive force equivalent to an adhesive force of between 110 N/m2 and 100,000 N/m2 measured on rat intestine, wherein the drug is selected from the group consisting of antibiotics, antivirals,

이 특허에 인용된 특허 (17)

  1. Steiner Solomon S. (Mt. Kisco NY), Anhydrous delivery systems for pharmacological agents.
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  2. Robinson Joseph R. (Madison WI), Bioadhesive composition and method of treatment therewith.
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  3. Friedman Doron,ILX ; Schwartz Joseph,ILX ; Amselem Shimon,ILX, Bioadhesive emulsion preparations for enhanced drug delivery.
    상세보기
  4. Mathiowitz Edith ; Chickering ; III Donald ; Jacob Jules S., Bioadhesive microspheres and their use as drug delivery and imaging systems.
    상세보기
  5. Mathiowitz Edith ; Chickering Donald ; Jacob Jules Serge, Bioadhesive microspheres and their use as drug delivery and imaging systems.
    상세보기
  6. Mathiowitz Edith ; Chickering Donald ; Jacob Jules Serge, Bioadhesive microspheres and their use as drug delivery and imaging systems.
    상세보기
  7. Braatz James A. (Beltsville MD) Heifetz Aaron H. (Columbia MD), Biocompatible, low protein adsorption affinity matrix.
    상세보기
  8. Gref Ruxandra (Nancy FRX) Minamitake Yoshiharu (Brookline MA) Langer Robert S. (Newton MA), Biodegradable injectable nanoparticles.
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  9. Domb Abraham J. (Baltimore MD) Maniar Manoj (Baltimore MD), Branched polyanhydrides.
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  10. Chow San-Laung (Perinton NY) Raghunathan Yegnaswami (Perinton NY), Coating barriers comprising ethyl cellulose.
    상세보기
  11. Orenstein Richard A. (Longmeadow MA) Dionne Arthur F. (Wilbraham MA), Low tack microsphere adhesive.
    상세보기
  12. Yen Richard C. K. (4261 Chase Ave. Los Angeles CA 90066), Manufacturing protein microspheres.
    상세보기
  13. Tice Thomas R. ; Gilley Richard M. ; Eldridge John H. ; Staas Jay K., Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissues and controlling their.
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  14. Bomberger David C. ; Catz Paul G. ; Smedley Mark I. ; Stearns Paul C., Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced.
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  15. Speaker Tully J. (Philadelphia PA) Sultzbaugh Kenneth J. (Philadelphia PA), Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses.
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  16. Soltys Paul J. (Somerville) Mullon Claudy J. P. (Burlington) Langer Robert S. (Somerville MA), Oral bilirubin therapy.
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  17. DeLuca Patrick P. (Lexington KY) Kanke Motoko (Fukuyama JPX) Sato Toyomi (Tokyo CA JPX) Schroeder Hans G. (Encinitas CA), Porous microspheres for drug delivery and methods for making same.
    상세보기

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