초록 ▼

Dosage forms and methods for providing sustained release of reboxetine are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma reboxetine concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plas

Dosage forms and methods for providing sustained release of reboxetine are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma reboxetine concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma reboxetine concentration occurrence in each 24 hour period. In addition, the peak plasma reboxetine concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma reboxetine concentration that occurs following administration of reboxetine in an immediate-release dosage form.

대표청구항 ▼

1. An osmotic dosage form adapted to release reboxetine at a uniform rate comprising:a. a semipermeable membrane defining an internal compartment; b. an osmotic composition component comprising reboxetine and a carbohydrate within the internal compartment; and c. a delivery orifice formed or formabl

1. An osmotic dosage form adapted to release reboxetine at a uniform rate comprising:a. a semipermeable membrane defining an internal compartment; b. an osmotic composition component comprising reboxetine and a carbohydrate within the internal compartment; and c. a delivery orifice formed or formable in the semipermeable membrane through which the reboxetine is delivered.