초록 ▼

Medical devices and systems for the localized delivery of genetic information to a target location within a mammalian body. In one embodiment, the system comprises a medical device insertable into the body and a biostable coating over at least part of the medical device. Genetic information is incor

Medical devices and systems for the localized delivery of genetic information to a target location within a mammalian body. In one embodiment, the system comprises a medical device insertable into the body and a biostable coating over at least part of the medical device. Genetic information is incorporated into the biostable coating before the medical device is placed into the body, and is released from the biostable coating at a target location within the body. The invention also includes methods for the localized delivery of genetic information to target locations within a mammalian body using the medical devices and systems of the invention.

대표청구항 ▼

1. A system for the localized delivery of genetic information to a target location within a mammalian body, comprising:a medical device insertable into the body; an aqueous-based biostable coating over at least part of said device; said biostable coating containing pores formed by freeze-drying said

1. A system for the localized delivery of genetic information to a target location within a mammalian body, comprising:a medical device insertable into the body; an aqueous-based biostable coating over at least part of said device; said biostable coating containing pores formed by freeze-drying said aqueous-based biostable coating and genetic information incorporated into said pores; wherein the genetic information comprises a material selected from the group consisting of nucleic acids, oligonucleotides, DNA compacting agents, recombinant nucleic acids, and gene/vector systems; which is released from said aqueous-based biostable coating at said target location.