초록 ▼

An antiproliferative, antiinflammatory, antiinfective, immunization agent of a metal ion chelating agent such as picolinic acid or derivatives thereof, and methods of using the same. The agents chelate metals in metal containing protein complexes required for growth, replication or inflammatory resp

An antiproliferative, antiinflammatory, antiinfective, immunization agent of a metal ion chelating agent such as picolinic acid or derivatives thereof, and methods of using the same. The agents chelate metals in metal containing protein complexes required for growth, replication or inflammatory response. The preparations can be administered systemically or for topical use. The preparations have antineoplastic, antiviral, antiinflammatory and antiproliferative effects and are used in the treatment of warts, psoriasis, acne, skin cancers, sunburn and other proliferative diseases and in the prevention of sexually transmitted diseases such as genital warts, herpes and AIDS. The agents also can be used to induce autologous immunological response.

대표청구항 ▼

1. A method of inactivating a virus containing a metal-protein complex comprising the step of exposing said virus to a metal chelating agent so that the metal chelating agent chelates said metal within said metal-protein complex so as to denature said protein and inactivate the virus, wherein said m

1. A method of inactivating a virus containing a metal-protein complex comprising the step of exposing said virus to a metal chelating agent so that the metal chelating agent chelates said metal within said metal-protein complex so as to denature said protein and inactivate the virus, wherein said metal chelating agent is represented by the following structure: [EQU1]or a pharmacologically acceptable salt thereof,wherein R1, R2, R3 and R4 are selected from the group consisting of a peptide of sixteen amino acids, carboxyl group, methyl group, ethyl group, propyl group, isopropyl group, butyl group, isobutyl group, secondary butyl group, tertiary butyl group, pentyl group, isopentyl group, neopentyl group, fluorine, chlorine, bromine, iodine, and hydrogen; wherein said metal chelating agent is not a zinc-picolinate complex prior to exposure to said virus.