Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-006/08
A61F-006/06
A61F-006/14
출원번호
US-0613441
(2000-07-11)
발명자
/ 주소
Merida A. D'Augustine
James H. Liu
Donald C. Harrison
출원인 / 주소
UMD, Inc.
대리인 / 주소
Hana Verny
인용정보
피인용 횟수 :
88인용 특허 :
28
초록
Devices, methods, and compositions for treating vaginal fungal, bacterial, viral and parasitic infections by intravaginal or transvaginal administration of therapeutic and/or palliative antifungal, antibacterial, antiviral or parasiticidal drugs to the vagina or to the uterus.
대표청구항▼
1. A medicated intravaginal device for delivery of an antifungal, antiviral, antibacterial, trichomonicidal or parasiticidal pharmaceutical agent intravaginally to a female vagina or transvaginally to uterus or general circulation through a vaginal mucosa, said device comprisinga vaginal tampon, vag
1. A medicated intravaginal device for delivery of an antifungal, antiviral, antibacterial, trichomonicidal or parasiticidal pharmaceutical agent intravaginally to a female vagina or transvaginally to uterus or general circulation through a vaginal mucosa, said device comprisinga vaginal tampon, vaginal ring, vaginal cup, vaginal tablet, vaginal sponge, or vaginal bioadhesive tablet incorporated with a composition comprising from about 0.1 to about 10%, by weight, the antifungal agent ,selected from the group consisting of miconazole, terconazole, isoconazole, fenticonazole, fluconazole, nystatin, ketoconazole, clotrimazole, butoconazole, econazole, tioconazole, itraconazole, 5-fluoracil and metronidazole, or the antiviral agent selected from the group consisting of acyclovir, femciclovir, valacyclovir and AZT, or the antibacterial agent selected from the group consisting of clindamycin, tetracycline, amoxicillin, ampicillin, erythromycin, doxycycline, lumefloxacin, norfloxacin, afloxam, ciproflaxin, azitromycin and cefltoxine present in amount from about, or the antichlamydial agent selected from the group consisting of tetracycline, doxycycline and erythromycin; or the trichomonicidal or parasiticidal agent selected from the group consisting of metronidazole and clotrimazol, or a combination thereof, said pharmaceutical agent in admixture with a pharmaceutically acceptable, non-toxic excipient comprising from about 60 to about 90%, by weight, of lipophilic or hydrophilic carrier and from about 5 to about 25%, by weight, of mucoadhesive agent for intravaginal delivery, or from about 60 to about 90%, by weight, of lipophilic or hydrophilic carrier, from about 5 to about 25%, by weight, of mucoadhesive agent and from about 5 and 20%, by weight, of penetration enhancer or sorption promoter for transvaginal delivery.
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