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Oligonucleotides having site specific chiral phosphorothioate internucleoside linkages 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/70
  • G01N-033/53
출원번호 US-0352058 (1999-07-14)
발명자 / 주소
  • Phillip Dan Cook
  • Muthiah Manoharan
출원인 / 주소
  • ISIS Pharmaceuticals, Inc.
대리인 / 주소
    Woodcock Washburn LLP
인용정보 피인용 횟수 : 37  인용 특허 : 91

초록

Novel chiral compounds that mimic and/or modulate the activity of wild-type nucleic acids are disclosed. In general, the compounds are phosphorothioate oligonucleotides wherein the 5', and the 3'-terminal internucleoside linkages are chirally Sp and internal internucleoside linkages are chirally Rp.

대표청구항 ▼

1. An oligomeric compound comprising a plurality of covalently-bound nucleosides; said compound having the formula:5'-T1-(Nu-Sp)n-(Nu-Lp)m-(NU-Sp)p-Nu-T2-3'wherein:T1 and T2 are each, independently, hydroxyl, a protected hydroxyl, a covalent attachment to a solid support, a nucleoside, an oligonucle

이 특허에 인용된 특허 (91)

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    • 이 특허를 인용한 특허 (37)

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