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Piperidine and pyrrolidine derivatives comprising a nitric oxide donor for treating stress 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/445
  • A61K-031/40
  • C07D-211/46
  • C07D-207/08
  • C07D-207/12
출원번호 US-0600711 (2000-09-05)
우선권정보 GB-0001398 (1998-01-22)
국제출원번호 PCT/GB99/00231 (1999-01-22)
§371/§102 date 20000905 (20000905)
국제공개번호 WO99/37616 (1999-07-29)
발명자 / 주소
  • Erik Emil Anggard GB
  • Abdullah Ibrahim Haj-Yehia IL
출원인 / 주소
  • Oxon Medica, Inc.
대리인 / 주소
    Morrison & Foerster LLP
인용정보 피인용 횟수 : 30  인용 특허 : 15

초록 ▼

The present invention relates to chemical compounds comprising a nitric oxide (NO) donor and a superoxide ion (O2-) scavenger, their preparation and their use in the treatment of conditions associated with oxidative stress or endothelial dysfunction. For example, the present invention relates to che

대표청구항

1. A compound, 4-nitrato-2,2,6,6-tetramethylpiperidinyloxy, free radical (TEMPO-4-mononitrate), or a pharmaceutically acceptable salt thereof.

이 특허에 인용된 특허 (15)

  1. del Soldato Piero,ITX, Antithrombotic organic nitrates.
    상세보기
  2. Sankaranarayanan Alangudi,INX, Benzofuroxan compound, method of preparation, pharmaceutical composition and method of treatment using the same.
    상세보기
  3. Sankaranarayanan Alangudi,INX, Benzofuroxan derivatives, their therapeutic uses and pharmaceutical compositions.
    상세보기
  4. Bombrun Agnes,FRX, Carboline derivatives.
    상세보기
  5. Del Soldato Piero,ITX ; Sannicolo' Francesco,ITX, Compounds and their compositions having anti-inflammatory and anti-thrombotic activities.
    상세보기
  6. Arena Barbara (Monza ITX) Del Soldato Piero (Monza ITX), Nitric esters having a pharmacological activity and process for their preparation.
    상세보기
  7. Del Soldato Piero,ITX, Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation.
    상세보기
  8. Soldato Piero Del (Monza ITX), Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation.
    상세보기
  9. Del Soldato Piero,ITX ; Sannicolo Francesco,ITX, Nitro compounds of the formula A-X.sub.i -NO.sub.2 and their compositions having anti-inflammatory, analgesic and anti-t.
    상세보기
  10. Garvey David S. ; Letts L. Gordon ; Renfroe H. Burt ; Richardson Stewart K., Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders.
    상세보기
  11. Garvey David S. ; Letts L. Gordon ; Renfroe H. Burt ; Richardson Stewart K., Nitrosated and nitrosylated steroids compositions, and methods for treating respiratory disorders.
    상세보기
  12. Slusher Barbara S. ; Jackson Paul F. ; Tays Kevin L. ; Maclin Keith M., Pharmaceutical compositions and methods of treating compulsive disorders using NAALADase inhibitors.
    상세보기
  13. Del Soldato Piero,ITX, Prostaglandin pharmaceutical compositions.
    상세보기
  14. Daugan Alain Claude-Marie,FRX ; Gellibert Francoise,FRX, Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use.
    상세보기
  15. Proctor Peter H. (4126 Southwest Freeway ; Suite 1616 Houston TX 77027), Topical tempo.
    상세보기

이 특허를 인용한 특허 (30)

  1. Fossel, Eric T., Beneficial effects of increasing local blood flow.
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  2. Haj Yehia,Abdullah Ibrahim, Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders.
    상세보기
  3. Fossel, Eric T., Delivery of ibuprofen and other compounds.
    상세보기
  4. Fossel, Eric T., Delivery of ibuprofen and other compounds.
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  5. Fossel, Eric T., Delivery of ibuprofen and other compounds.
    상세보기
  6. Bauman, Susanne; Stasko, Nathan A., Methods of decreasing sebum production in the skin.
    상세보기
  7. Thatcher, Gregory R. J.; Bennett, Brian M.; Reynolds, James N.; Boegman, Roland J.; Jhamandas, Khem, Nitrate esters and methods of making same.
    상세보기
  8. Schoenfisch, Mark; Riccio, Daniel; Nugent, Julia; Stasko, Nathan, Nitric oxide-releasing S-nitrosothiol-modified silica particles and methods of making the same.
    상세보기
  9. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
    상세보기
  10. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
    상세보기
  11. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
    상세보기
  12. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
    상세보기
  13. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
    상세보기
  14. Fossel, Eric T., Systems and methods for treatment of allergies and other indications.
    상세보기
  15. Schoenfisch, Mark; Riccio, Daniel, Tertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the same.
    상세보기
  16. Fossel, Eric T., Topical composition containing ibuprofen.
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  17. Fossel, Eric T., Topical composition containing naproxen.
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  18. Fossel, Eric T., Topical delivery of L-arginine to cause beneficial effects.
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  19. Fossel, Eric T., Topical delivery of L-arginine to cause beneficial effects.
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  20. Stasko, Nathan; Bauman, Susanne; Joshi, Pranav R., Topical gels and methods of using the same.
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  21. Stasko, Nathan; Bauman, Susanne; Joshi, Pranav R., Topical gels and methods of using the same.
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  22. Fossel, Eric Thor, Transdermal delivery of beneficial substances effected by a hostile biophysical environment.
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  23. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
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  24. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
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  25. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
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  26. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
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  27. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
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  28. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
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  29. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
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  30. Stasko, Nathan; Bauman, Susanne; Joshi, Pranav R., Wound dressings, methods of using the same and methods of forming the same.
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