$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[미국특허] Hepatocyte lineage cells derived from pluripotent stem cells 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-005/08
  • C12N-005/00
  • C12N-005/02
출원번호 US-0718308 (2000-11-20)
발명자 / 주소
  • Lakshmi Rambhatla
  • Melissa K. Carpenter
출원인 / 주소
  • Geron Corporation
대리인 / 주소
    J. Michael Schiff
인용정보 피인용 횟수 : 108  인용 특허 : 7

초록 ▼

It has been discovered that when pluripotent stem cells are cultured in the presence of a hepatocyte differentiation agent, a population of cells is derived that has a remarkably high proportion of cells with phenotypic characteristics of liver cells. In one example, human embryonic stem cells are a

대표청구항 ▼

1. A set of isolated cell populations, consisting of:a first cell population that comprises undifferentiated cells from a line of human embryonic stem (hES) cells; and a second cell population, wherein at least .about.60% of the cells in the second population are progeny of said hES cell line, and h

이 특허에 인용된 특허 (7) 인용/피인용 타임라인 분석

  1. Talbot Neil (Silver Spring MD) Rexroad ; Jr. Caird E. (Gambrills MD) Pursel Vernon G. (Highland MD) Powell Anne M. (Bowie MD), Hepatocyte cell line derived from the epiblast of pig blastocysts.
    상세보기
  2. Jauregui Hugo O. ; Liu Jin, Immortalized hepatocytes.
    상세보기
  3. Swiderek Mark S. ; Mannuzza Frank J., Inducing epithelial cell differentiation with dried native fibrillar collagen.
    상세보기
  4. Jauregui Hugo O. ; Naik Sharda ; Santangini Henry ; Trenkler Donna M., Isolation and culture of porcine hepatocytes.
    상세보기
  5. Naughton Brian A. (El Cajon CA) Sibanda Benson (Oceanside CA), Liver reserve cells.
    상세보기
  6. Reid Lola M. (Chapel Hill NC) Agelli Maria (Summit NJ) Ochs Andreas (Bronx NY), Method of expanding hepatic precursor cells.
    상세보기
  7. Kuri-Harcuch Walid (Mxico D. F. MXX) Mendoza-Figueroa Tomas (Mxico D. F. MXX), Process for the long-term surviving culture of hepatocytes.
    상세보기

이 특허를 인용한 특허 (108) 인용/피인용 타임라인 분석

  1. Bohlen, Heribert; Jönsson, Kristina; Ehlich, Andreas; Schwengberg, Silke, Assay for drug discovery based on in vitro differentiated cells.
    상세보기
  2. Petersen,Bryon E.; Oh,Seh hoon, Bone marrow cell differentiation.
    상세보기
  3. Rezania, Alireza, Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm.
    상세보기
  4. Mistry, Sanjay, Cellular therapy for ocular degeneration.
    상세보기
  5. Rezania, Alireza, Defined media for expansion and maintenance of pluripotent stem cells.
    상세보기
  6. Rezania, Alireza, Defined media for expansion and maintenance of pluripotent stem cells.
    상세보기
  7. D'Amour, Kevin Allen; Agulnick, Alan D.; Baetge, Emmanuel E., Definitive endoderm.
    상세보기
  8. D'Amour, Kevin Allen; Agulnick, Alan D.; Baetge, Emmanuel E., Definitive endoderm.
    상세보기
  9. D'Amour,Kevin Allen; Agulnick,Alan D.; Baetge,Emmanuel E., Definitive endoderm.
    상세보기
  10. Lebkowski, Jane S.; Priest, Catherine A.; Okamura, Ross M., Differentiated pluripotent stem cell progeny depleted of extraneous phenotypes.
    상세보기
  11. Lebkowski, Jane S.; Priest, Catherine Ann; Okamura, Ross M., Differentiated pluripotent stem cell progeny depleted of extraneous phenotypes.
    상세보기
  12. Davis, Janet; Parmenter, Christine; Ditolvo, Kevin, Differentiation of human embryonic stem cells.
    상세보기
  13. Fryer, Benjamin, Differentiation of human embryonic stem cells.
    상세보기
  14. Fryer, Benjamin, Differentiation of human embryonic stem cells.
    상세보기
  15. Rezania, Alireza, Differentiation of human embryonic stem cells.
    상세보기
  16. Rezania, Alireza, Differentiation of human embryonic stem cells.
    상세보기
  17. Rezania, Alireza, Differentiation of human embryonic stem cells.
    상세보기
  18. Rezania, Alireza, Differentiation of human embryonic stem cells.
    상세보기
  19. Rezania, Alireza, Differentiation of human embryonic stem cells.
    상세보기
  20. Rezania, Alireza; Xu, Jean, Differentiation of human embryonic stem cells.
    상세보기
  21. Xu, Jean, Differentiation of human embryonic stem cells.
    상세보기
  22. Xu, Jean, Differentiation of human embryonic stem cells.
    상세보기
  23. Xu, Jean, Differentiation of human embryonic stem cells.
    상세보기
  24. Xu, Jean, Differentiation of human embryonic stem cells.
    상세보기
  25. Xu, Jean, Differentiation of human embryonic stem cells.
    상세보기
  26. Xu, Jean, Differentiation of human embryonic stem cells.
    상세보기
  27. Xu, Jean, Differentiation of human embryonic stem cells.
    상세보기
  28. Xu, Jean; Jensen, Jan, Differentiation of human embryonic stem cells.
    상세보기
  29. Rezania, Alireza, Differentiation of human embryonic stem cells into pancreatic endocrine cells.
    상세보기
  30. Rezania, Alireza, Differentiation of human embryonic stem cells into pancreatic endocrine cells.
    상세보기
  31. Rezania, Alireza, Differentiation of human embryonic stem cells into pancreatic endocrine cells using HB9 regulators.
    상세보기
  32. Rezania, Alireza; Fryer, Benjamin, Differentiation of human pluripotent stem cells.
    상세보기
  33. Rezania, Alireza; Fryer, Benjamin, Differentiation of human pluripotent stem cells.
    상세보기
  34. Davis, Janet; Liu, Jiajian; Parmenter, Christine; Bonnet, Pascal Ghislain Andre, Differentiation of pluripotent stem cells.
    상세보기
  35. Davis, Janet; Liu, Jiajian; Parmenter, Christine; Bonnet, Pascal Ghislain André, Differentiation of pluripotent stem cells.
    상세보기
  36. Davis, Janet; Liu, Jiajian; Parmenter, Christine; Bonnet, Pascal Ghislain André, Differentiation of pluripotent stem cells.
    상세보기
  37. Rezania, Alireza, Differentiation of pluripotent stem cells.
    상세보기
  38. Rezania, Alireza, Differentiation of pluripotent stem cells.
    상세보기
  39. Rezania, Alireza; Xu, Jean, Differentiation of pluripotent stem cells to definitive endoderm lineage.
    상세보기
  40. Zhao, Debiao; Majumdar, Anish Sen; Hay, David C.; Cui, Wei, Differentiation of primate pluripotent cells to hepatocyte-lineage cells.
    상세보기
  41. Martinson, Laura; Green, Chad; Kroon, Evert; Agulnick, Alan; Kelly, Olivia; Baetge, Emmanuel E., Encapsulation of pancreatic cells derived from human pluripotent stem cells.
    상세보기
  42. Martinson, Laura; Green, Chad; Kroon, Evert; Baetge, Emmanuel Edward, Encapsulation of pancreatic cells derived from human pluripotent stem cells.
    상세보기
  43. Martinson, Laura; Green, Chad; Kroon, Evert; Baetge, Emmanuel Edward, Encapsulation of pancreatic cells derived from human pluripotent stem cells.
    상세보기
  44. Martinson, Laura; Green, Chad; Kroon, Evert; Baetge, Emmanuel Edward, Encapsulation of pancreatic cells derived from human pluripotent stem cells.
    상세보기
  45. D'Amour, Kevin A.; Bang, Anne; Baetge, Emmanuel E., Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production.
    상세보기
  46. D'Amour, Kevin A.; Bang, Anne; Baetge, Emmanuel E., Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production.
    상세보기
  47. Kelly, Olivia; Baetge, Emmanuel E.; Carpenter, Melissa, Expansion of definitive endoderm cells.
    상세보기
  48. Kelly, Olivia; Baetge, Emmanuel E.; Carpenter, Melissa, Expansion of definitive endoderm cells.
    상세보기
  49. Sherley, James L.; Lee, Hsuan-Shu; Crane, Gracy G., Hepatocyte precursor cell lines.
    상세보기
  50. Yang, Mei Ju; Chang, Kuang Ning; Hsu, Lih Tao; Huang, Jun Jae; Chen, Wann Hsin; Kuo, Chao Ying, Human embryonic stem cells and culturing methods thereof.
    상세보기
  51. Mandalam, Ramkumar; Xu, Chunhui; Gold, Joseph D.; Carpenter, Melissa K., Human embryonic stem cells genetically modified to contain a nucleic acid and cultured with fibroblast growth factor.
    상세보기
  52. Prachumsri,Jetsumon; Yimamnuaychok,Nongnuch, Human liver cell line.
    상세보기
  53. Gold, Joseph D.; Lebkowski, Jane S., In vitro differentiated cell and human embryonic stem cell population.
    상세보기
  54. Gold, Joseph D; Lebkowski, Jane S, Isolated in vitro cell population comprising primate pluripotent stem cells containing a nucleic acid construct and differentiated progeny of the pluripotent stem cells.
    상세보기
  55. D'Amour, Kevin Allen; Agulnick, Alan D.; Baetge, Emmanuel Edward, Markers of definitive endoderm.
    상세보기
  56. D'Amour, Kevin Allen; Agulnick, Alan D; Baetge, Emmanuel Edward, Markers of definitive endoderm.
    상세보기
  57. Chen, Ya Xiong; Fryer, Benjamin, Methods and compositions for cell attachment and cultivation on planar substrates.
    상세보기
  58. D'Amour, Kevin Allen; Agulnick, Alan D.; Eliazer, Susan; Baetge, Emmanuel E., Methods for identifying factors for differentiating definitive endoderm.
    상세보기
  59. D'Amour, Kevin Allen; Agulnick, Alan D.; Eliazer, Susan; Baetge, Emmanuel E., Methods for identifying factors for differentiating definitive endoderm.
    상세보기
  60. Dalton, Stephen; Sheppard, Allan; Jones, Karen; Baetge, E. Edward; D'Amour, Kevin A.; Agulnick, Alan D., Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors.
    상세보기
  61. Agulnick, Alan; D'Amour, Kevin; Baetge, Emmanuel Edward, Methods for increasing definitive endoderm production.
    상세보기
  62. Agulnick, Alan; D'Amour, Kevin; Baetge, Emmanuel Edward, Methods for increasing definitive endoderm production.
    상세보기
  63. Ochiya,Takahiro; Teratani,Takumi, Methods for inducing differentiation of pluripotent cells.
    상세보기
  64. D'Amour, Kevin Allen; Agulnick, Alan D.; Eliazer, Susan; Baetge, Emmanuel E., Methods for making anterior foregut endoderm.
    상세보기
  65. Karanu, Francis; Rezania, Alireza, Methods for purifying cells derived from pluripotent stem cells.
    상세보기
  66. D'Amour, Kevin Allen; Agulnick, Alan D.; Eliazer, Susan; Kroon, Evert; Baetge, Emmanuel E., Methods of making human primitive ectoderm cells.
    상세보기
  67. Martinson, Laura; Kroon, Evert; D'Amour, Kevin; Baetge, Emmanuel Edward, Methods of producing pancreatic hormones.
    상세보기
  68. Martinson, Laura; Kroon, Evert; D'Amour, Kevin; Baetge, Emmanuel Edward, Methods of producing pancreatic hormones.
    상세보기
  69. Martinson, Laura; Kroon, Evert; D'Amour, Kevin; Baetge, Emmanuel Edward, Methods of producing pancreatic hormones.
    상세보기
  70. Martinson, Laura; Kroon, Evert; D'Amour, Kevin; Baetge, Emmanuel Edward, Methods of producing pancreatic hormones.
    상세보기
  71. Fryer, Benjamin; Nelson, Shelley; Nielsen, Villy; Marwood, Tina Kristensen; Brevig, Thomas, Methods, surface modified plates and compositions for cell attachment, cultivation and detachment.
    상세보기
  72. Mandalam, Ramkumar; Xu, Chunhui; Gold, Joseph D.; Carpenter, Melissa K., Micro-carrier culture system for rapid expansion of human embryonic stem cells.
    상세보기
  73. Carpenter, Melissa K.; Thies, R. Scott, Neural cell populations from primate pluripotent stem cells.
    상세보기
  74. Carpenter, Melissa K.; Thies, R. Scott, Neural cell populations from primate pluripotent stem cells.
    상세보기
  75. Carpenter, Melissa K., Neural progenitor cell populations.
    상세보기
  76. Carpenter, Melissa K., Neural progenitor cell populations.
    상세보기
  77. Carpenter, Melissa K., Neural progenitor cell populations.
    상세보기
  78. Bohlen, Heribert; Kolossov, Eugen; Kettenhofen, Ralf; Scholz, Melanie; Fink, Leo, Non-invasive, in vitro functional tissue assay systems.
    상세보기
  79. D'Amour, Kevin Allen; Agulnick, Alan D.; Eliazer, Susan; Baetge, Emmanuel E., PDX1 expressing endoderm.
    상세보기
  80. D'Amour, Kevin Allen; Agulnick, Alan D.; Eliazer, Susan; Baetge, Emmanuel E., PDX1 expressing endoderm.
    상세보기
  81. D'Amour, Kevin Allen; Agulnick, Alan D.; Eliazer, Susan; Baetge, Emmanuel E., PDX1-expressing dorsal and ventral foregut endoderm.
    상세보기
  82. Nelson, Shelley, Pluripotent stem cell culture on micro-carriers.
    상세보기
  83. Mattheakis, Larry C.; Trautman, Jay Kenneth; Solar, Gregg Peter; Fan, Jinhong; Vaisberg, Eugeni; Adams, Cynthia Lynn; Rao, Aibing, Predicting hepatotoxicity using cell based assays.
    상세보기
  84. D'Amour, Kevin Allen; Agulnick, Alan D.; Baetge, Emmanuel E., Preprimitive streak and mesendoderm cells.
    상세보기
  85. D'Amour, Kevin Allen; Agulnick, Alan D.; Eliazar, Susan; Kroon, Evert; Baetge, Emmanuel E., Preprimitive streak and mesendoderm cells.
    상세보기
  86. Mandalam, Ramkumar; Xu, Chunhui; Gold, Joseph D.; Carpenter, Melissa K., Primate pluripotent stem cell expansion without feeder cells and in the presence of FGF and matrigel or Engelbreth-Holm-Swarm tumor cell preparation.
    상세보기
  87. Mandalam, Ramkumar; Faouzi, Saadia; Nadeau, Isabelle; Pfendler-Bonham, Kristina; Rao, Namitha; Carpenter, Melissa K.; Rambhatla, Lakshmi; Chiu, Choy-Pik, Protocols for making hepatocytes from embryonic stem cells.
    상세보기
  88. Mandalam, Ramkumar; Faouzi, Saadia; Nadeau, Isabelle; Pfendler-Bonham, Kristina; Rao, Namitha; Carpenter, Melissa K.; Rambhatla, Lakshmi; Chiu, Choy-Pik, Protocols for making hepatocytes from embryonic stem cells.
    상세보기
  89. Mandalam,Ramkumar; Faouzi,Saadia; Nadeau,Isabelle; Pfendler Bonham,Kristina; Rao,Namitha; Carpenter,Melissa K.; Rambhatla,Lakshmi; Chiu,Choy Pik, Protocols for making hepatocytes from embryonic stem cells.
    상세보기
  90. Mandalam, Ramkumar; Xu, Chunhui; Gold, Joseph D.; Carpenter, Melissa K., Screening methods for human embryonic stem cells.
    상세보기
  91. Prachumsri, Jetsumon; Yimamnuaychok, Nongnuch, Screening methods using normal human liver cell line.
    상세보기
  92. Carpenter,Melissa K.; Denham,Jerrod J.; Inokuma,Margaret S.; Thies,R. Scott, Screening small molecule drugs using neural cells differentiated from human embryonic stem cells.
    상세보기
  93. Rezania, Alireza; Ghabrial, Ragae, Seeding cells on porous supports.
    상세보기
  94. Nelson, Shelley, Single pluripotent stem cell culture.
    상세보기
  95. Mandalam, Ramkumar; Li, Yan; Nadeau-Demers, Isabelle, Suspension culture of human embryonic stem cells.
    상세보기
  96. Shogbon, Christopher Bankole; Zhou, Yue; Brandenberger, Ralph, Synthetic surfaces for culturing stem cell derived cardiomyocytes.
    상세보기
  97. Shogbon, Christopher Bankole; Zhou, Yue; Brandenberger, Ralph, Synthetic surfaces for culturing stem cell derived cardiomyocytes.
    상세보기
  98. Shogbon, Christopher Bankole; Zhou, Yue; Brandenberger, Ralph, Synthetic surfaces for culturing stem cell derived cardiomyocytes.
    상세보기
  99. Kolossov, Eugen; Hescheler, Jürgen; Bohlen, Heribert; Fleischmann, Bernd; Röll, Wilhelm; Ehlich, Andreas; Königsmann, Jessica, Tissue modeling in embryonic stem (ES) cell system.
    상세보기
  100. Snodgrass, H. Ralph, Toxicity typing using liver stem cells.
    상세보기
  101. Snodgrass, H. Ralph, Toxicity typing using liver stem cells.
    상세보기
  102. Davis, Janet; Liu, Jiajian, Treatment of pluripotent cells.
    상세보기
  103. Davis, Janet; Liu, Jiajian, Treatment of pluripotent cells.
    상세보기
  104. Carpenter, Melissa K.; Thies, R. Scott, Use of TGF beta superfamily antagonists and neurotrophins to make neurons from embryonic stem cells.
    상세보기
  105. Carpenter, Melissa K.; Thies, R. Scott, Use of TGF beta superfamily antagonists to make dopaminergic neurons from embryonic stem cells.
    상세보기
  106. Carpenter, Melissa K.; Thies, R. Scott, Use of cyclic AMP and ascorbic acid to produce dopaminergic neurons from embryonic stem cells.
    상세보기
  107. Rezania, Alireza, Use of small molecules to enhance MAFA expression in pancreatic endocrine cells.
    상세보기
  108. Ratajczak, Mariusz; Kucia, Magdalena; Ratajczak, Janina; Bolli, Roberto, Uses and isolation of stem cells from bone marrow.
    상세보기

활용도 분석정보

상세보기
다운로드
내보내기

활용도 Top5 특허

해당 특허가 속한 카테고리에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

관련 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로