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[미국특허] Cyclic implant perfusion cleaning and passivation process 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A01N-001/02
출원번호 US-0191232 (1998-11-13)
발명자 / 주소
  • C. Randal Mills
  • John F. Wironen
출원인 / 주소
  • Regeneration Technologies, Inc.
대리인 / 주소
    Van Dyke & Associates, P.A.
인용정보 피인용 횟수 : 62  인용 특허 : 17

초록

This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorgani

대표청구항

1. An implant cleaning, perfusion and passivation process which comprises subjecting the entire implant to cyclic exposure of increased and decreased pressure above one atmosphere or below one atmosphere or both, wherein said implant consists essentially of autograft, allograft or xenograft tissue,

이 특허에 인용된 특허 (17) 인용/피인용 타임라인 분석

  1. Knaepler Harald (Beltershausen DEX) von Garrel Thomas (Marburg DEX), Apparatus for sterilizing bone grafts.
  2. Urist Marshall R. (Pacific Palisade CA), Bone morphogenetic protein process.
  3. Abraham Ginger A. ; Carr ; Jr. Robert M. ; Kemp Paul D.,GBX ; Mercer Ryan ; Baker Linda, Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix.
  4. Kotsopey Omelan, Cleaning apparatus.
  5. Young Jack H. (Crawford PA) Karle David A. (Erie PA) Halleck Frank E. (Erie PA), Combined ultrasonic cleaning and biocidal treatment in a single pressure vessel.
  6. Carr James Michael, Decontamination of devices and instruments contacted with body tissues.
  7. Carr James M. (Cos Cob CT), Decontamination of orthopaedic implants.
  8. Morse Brenda S. (Chamblee GA) Dioh Clement D. (Marietta GA), Preparation of bone for transplantation.
  9. Morse Brenda S. (Chamblee GA) Shanbrom Edward (Santa Ana CA), Preparation of bone for transplantation.
  10. Scarborough Nelson L. ; Morris John W. ; Russell James L. ; Dowd Michael, Pressure flow system and method for treating a fluid permeable workpiece such as a bone.
  11. Wolfinbarger ; Jr. Lloyd, Process and composition for cleaning soft tissue grafts optionally attached to bone and soft tissue and bone grafts produced thereby.
  12. Wolfinbarger Lloyd (Norfolk VA), Process for cleaning large bone grafts and bone grafts produced thereby.
  13. O\Leary Robert K. (Spring Lake NJ), Process for disinfecting musculoskeletal tissue and tissues prepared thereby.
  14. Fages Jacques,FRX ; Marty Alain,FRX ; Combes Didier,FRX ; Condoret Jean-Stephane,FRX, Process for treating bone tissue and corresponding implantable biomaterials.
  15. Carter Stephen D. (Stone Mountain GA) Brazell James W. (Atlanta GA), Sterilization apparatus and method.
  16. Castor Trevor P. (Arlington MA) Hong Glenn T. (Tewksbury MA), Supercritical fluid disruption of and extraction from microbial cells.
  17. Wolfinbarger ; Jr. Lloyd, Ultrasonic cleaning of allograft bone.

이 특허를 인용한 특허 (62) 인용/피인용 타임라인 분석

  1. Bianchi, John R.; Arunas, Zhukauskas A.; Goede, Todd E.; Brown, Lauren M.; Grover, Guy B.; Lewis, Wesley I.; Kutsavage, Joe, Adjustable and fixed assembled bone-tendon-bone graft.
  2. Bianchi, John R.; Zhukauskas, Arunas A.; Goede, Todd E.; Brown, Lauren M.; Grover, Guy B.; Lewis, Wesley I.; Kutsavage, Joe, Adjustable and fixed assembled bone-tendon-bone graft.
  3. Chataigner, Hervé; Chebuhar, Craig; Dinville, Hervé; Bougere, Emmanuel, Anchoring device and system for an intervertebral implant, intervertebral implant and implantation instrument.
  4. Chataigner, Hervé; Chebuhar, Craig; Dinville, Hervé; Bougere, Emmanuel, Anchoring device and system for an intervertebral implant, intervertebral implant and implantation instrument.
  5. Dinville, Hervé; Lequette, Samuel; Delhaye, Manuel; Parent, Henry François; Faline, Alexis; Lawner, Pablo; Zahrawi, Faissal; Bierstedt, Thomas, Anchoring device and system for an intervertebral implant, intervertebral implant and implantation instrument.
  6. Dinville, Hervé; Lequette, Samuel; Delhaye, Manuel; Parent, Henry François; Faline, Alexis; Lawner, Pablo; Zahrawi, Faissal; Bierstedt, Thomas, Anchoring device and system for an intervertebral implant, intervertebral implant and implantation instrument.
  7. Michelson, Gary K., Arcuate interbody spinal fusion implant having a reduced width and an anatomically conformed trailing end.
  8. Michelson, Gary K., Artificial hemi-lumbar interbody spinal fusion cage having an asymmetrical leading end.
  9. Michelson, Gary K., Artificial hemi-lumbar interbody spinal implant having an asymmetrical leading end.
  10. Bianchi, John R.; Lewis, Wesley I.; Kutsavage, Joe; Urbaniak, Dan; Carr, Angela; Klein, Glenn C.; Sanders, Ben R., Assembled bone-tendon-bone grafts.
  11. Bianchi, John R.; Mills, C. Randal; Gorham, P. J.; Esch, Michael; Carter, Kevin C.; Coleman, Pat; Ross, Kevin; Rambo, Harry W.; Jones, Darren G.; Buskirk, Dayna, Assembled implant.
  12. Clineff, Theodore D.; Darmoc, Marissa M.; Brown, Lauren, Bioactive antibacterial bone graft materials.
  13. Xu, Guo-Feng, Biological artificial blood vessel and method of making.
  14. Xu, Guo-Feng, Biological artificial nerve guide and method of making.
  15. Qi, Song-Tao; Xu, Guo-Feng, Biological membrane-carrying aneurysm clip.
  16. Xu, Guo-Feng, Biological surgical patch and method of making.
  17. Bianchi, John R.; Lewis, Wesley I., Bone block assemblies and their use in assembled bone-tendon-bone grafts.
  18. Michelson, Gary K., Bone hemi-lumbar arcuate interbody spinal fusion implant having an asymmetrical leading end.
  19. Padmini, Rangamani; Orban, Janine; Malaviya, Prasanna, Chemical treatment for removing cellular and nuclear material from naturally occurring extracellular matrix-based biomaterials.
  20. Chen, Silvia S.; Qin, Xiaofei; Chen, Jingsong; Wolfinbarger, Jr., Lloyd, Crafting of cartilage.
  21. Mezger, W. Jerry; Myers, Keith E., Crosslinked human or animal tissue products and their methods of manufacture and use.
  22. Mezger, W. Jerry; Myers, Keith E., Crosslinked human or animal tissue products and their methods of manufacture and use.
  23. Mezger, W. Jerry; Myers, Keith E., Crosslinked human or animal tissue products and their methods of manufacture and use.
  24. Mezger, W. Jerry; Myers, Keith E., Crosslinked human or animal tissue products and their methods of manufacture and use.
  25. Mills, C. Randal; Wironen, John F.; Hanstke, Sean, Cyclic implant perfusion, cleaning and passivation process and implant produced thereby.
  26. Mills, C. Randal; Wironen, John F.; Hanstke, Sean, Cyclic implant perfusion, cleaning and passivation process and implant produced thereby.
  27. Mills, C. Randal; Wironen, John F.; Hanstke, Sean, Cyclic implant perfusion, cleaning and passivation process and implant produced thereby.
  28. Sagripanti, Jose Luis, Hand-held device with reagents and method for detection and diagnostics.
  29. Michelson, Gary K., Hemi-interbody spinal fusion implants manufactured from a major long bone ring.
  30. Carboulec, Nicolas Pierre Yves; Labatut, Rene; Gerentes, Lionel, Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins.
  31. Dinville, Hervé; LeQuette, Samuel; Bougère, Emmanuel, Instruments and methods for removing fixation devices from intervertebral implants.
  32. Michelson, Gary K., Interbody spinal fusion implant having an anatomically conformed trailing end.
  33. Bianchi, John R; Lewis, Wesley I, Intermediate bone block and its use in bone block assemblies and assembled bone-tendon-bone grafts.
  34. Allain, Jérôme; Lombard, Jean; Phelps, Jeff; Nunley, Pierce D.; Gordon, Charles; Leone, Vincent J.; Hisey, Michael M. D., Intersomatic cage, intervertebral prosthesis, anchoring device and implantation instruments.
  35. Rashbaum, Ralph; Kim, Kee D.; Bae, Hyun, Intervertebral disc prosthesis.
  36. Brett, Darrell C., Intervertebral implant having extendable bone fixation members.
  37. Konertz, Wolfgang; Dohmen, Pascal, Method for decellularizing foreign material to produce bioprostheses.
  38. Michelson, Gary K., Method for inserting an interbody spinal fusion implant having an anatomically conformed trailing end.
  39. Park, Chang Soo; Lee, Yun Jin, Method for producing a bone transplant material, and bone transplant material produced by same.
  40. Brahmbhatt, Sudhir R.; Masi, Richard R., Methods and systems for sanitizing or sterilizing a medical device using ultrasonic energy and liquid nitrogen.
  41. Ronholdt, Chad, Methods for determining microbial contamination of allograft products.
  42. Ronholdt, Chad J., Methods for determining microbial contamination of allograft products.
  43. Michelson, Gary K., Nested interbody spinal fusion implants.
  44. Goede, Todd E.; Zhukauskas, Arunas A.; Schmitt, Eric; Grover, Guy B., Orthopedic bone block.
  45. Zhukauskas, Arunas A.; Grover, Guy B., Orthopedic bone block.
  46. Goede, Todd E.; Zhukauskas, Arunas A.; Schmitt, Eric; Grover, Guy B., Orthopedic bone block assembly.
  47. Lewis, Wesley I.; Bianchi, John R.; Kutsavage, Joe; Zhukauskas, Arunas A., Orthopedic bone block assembly.
  48. Lewis, Wesley I.; Bianchi, John R.; Kutsavage, Joe; Zhukauskas, Arunas A., Orthopedic bone block assembly.
  49. Wolfinbarger, Jr., Lloyd; O'Leary, Robert K.; Anderson, Billy G., Plasticized bone and soft tissue grafts and methods of making and using same.
  50. Wolfinbarger, Jr., Lloyd; O'Leary, Robert K.; Anderson, Billy G., Plasticized bone and soft tissue grafts and methods of making and using same.
  51. Wolfinbarger, Jr., Lloyd; O'Leary, Robert K.; Anderson, Billy G., Plasticized bone and soft tissue grafts and methods of making and using same.
  52. Mills, C. Randal; Bianchi, John R.; Roberts, Michael R.; Nataraj, Chandrasekaran, Process and apparatus for treating implants comprising soft tissue.
  53. Wolfinbarger, Jr., Lloyd; Lange, Perry; Linthurst-Jones, Alyce; Moore, Eric; Nolf, Barry, Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced.
  54. Zhukauskas, Arunas A.; Goede, Todd E.; Schmitt, Eric J.; Brown, Lauren M.; Grover, Guy B.; Bursac, Predrag; Sanders, Ben R., Progressive grip assembled bone-tendon-bone grafts, methods of making, and methods of use.
  55. Olsen, Raymond E.; Lewis, Wesley I.; Bianchi, John R.; Kutsavage, Joe; Urbaniak, Daniel J.; Carr, Angela; Sanders, Ben R., Self fixing assembled bone-tendon-bone graft.
  56. Zhukauskas, Arunas A.; Goede, Todd E.; Brown, Lauren M.; Bianchi, John R.; Lewis, Wesley I.; Kutsavage, Joe, Set of orthopedic bone block assemblies.
  57. Michelson, Gary K., Spinal fusion implant with bone screws and a bone screw lock.
  58. Michelson, Gary K., Spinal fusion implant with bone screws and a bone screw lock.
  59. Davis, Reginald James; Kaufman, Kevin; Hoffman, Greg; McGee, Alan; Huppert, Jean; Mousselard, Hugues; Rillardon, Ludovic, Transforaminal intersomatic cage for an intervertebral fusion graft and an instrument for implanting the cage.
  60. Davis, Reginald James; Kaufman, Kevin; Hoffman, Greg; McGee, Alan; Huppert, Jean; Mousselard, Hugues; Rillardon, Ludovic, Transforaminal intersomatic cage for an intervertebral fusion graft and an instrument for implanting the cage.
  61. Squillace, Donna, Vascular graft sterilization and decellularization.
  62. Louis, Christian; Huppert, Jean; Tropiano, Patrick; Dufour, Thierry, Vertebral cage device with modular fixation.

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