초록 ▼

A stable formulation is disclosed that enables the effective intra-oral delivery to a patient of a pharmaceutical agent. The formulation comprises the pharmaceutical agent mixed with an orally-acceptable oral-absorption enhancer in an orally-acceptable carrier-solvent, wherein the oral-absorption en

A stable formulation is disclosed that enables the effective intra-oral delivery to a patient of a pharmaceutical agent. The formulation comprises the pharmaceutical agent mixed with an orally-acceptable oral-absorption enhancer in an orally-acceptable carrier-solvent, wherein the oral-absorption enhancer is adapted to modify the surface membrane such that absorption through the surface membrane is initiated or increased. The oral-absorption enhancer may comprise hydroxypropyl-beta-cyclodextrin and surfactants including benzalkonium chloride, benzethonium chloride, polysorbate 80, sodium lauryl sulfate, Brij surfactants, Tween and Pluronic surfactants. Also disclosed is a system for delivering the formulation including a mechanism for dispensing predetermined doses of the inventive formulation intra-orally as with an aerosol or spray pump or propellant device.

대표청구항 ▼

1. A substantially nonaqueous formulation for intra-oral delivery of at least one pharmaceutical agent to a patient comprising a solid or liquid dispersion comprising an effective amount of the pharmaceutical agent and at least one of (i) an orally-acceptable oral-absorptive enhancer operable to mod

1. A substantially nonaqueous formulation for intra-oral delivery of at least one pharmaceutical agent to a patient comprising a solid or liquid dispersion comprising an effective amount of the pharmaceutical agent and at least one of (i) an orally-acceptable oral-absorptive enhancer operable to modify the absorptive surface of the targeted intra-oral membrane and enhance bioavailability of the pharmaceutical agent across the membrane and (ii) a formulation surfactant at least sufficient to increase the miscibility of the pharmaceutical agent, in an orally-acceptable nonaqueous carrier-solvent.