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Nasal transmucosal delivery of peptide conjugated with biocompatible polymers 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-038/09
  • A61K-038/17
  • A61K-038/23
  • A61K-038/28
  • A61K-038/29
출원번호 US-0639483 (2000-08-15)
우선권정보 KR-0033984 (1999-08-17)
발명자 / 주소
  • Lee, Kang Choon
  • Park, Myung-Ok
대리인 / 주소
    Roberts & Mercanti, LLP
인용정보 피인용 횟수 : 37  인용 특허 : 2

초록 ▼

The present invention relates to a pharmaceutical composition for the nasal transmucosal delivery of a biocompatible polymer-biologically active peptide conjugate. The pharmaceutical composition of the present invention increases the water solubility of peptide, which is sparingly soluble in water,

대표청구항 ▼

1. A method of treatment, comprising administering an effective amount of a pharmaceutical composition containing calcitonin conjugated to polyethylene glycol via nasal transmucosal delivery to a mammal in need thereof. 2. The method of claim 1, wherein the calcitonin is conjugated to said polyethyl

이 특허에 인용된 특허 (2)

  1. Ekwuribe Nnochiri Nkem (Cary NC), Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method.
    상세보기
  2. Hoffman Allan S. ; Hayashi Yoshiki,JPX, Pegylated drug complexed with bioadhesive polymer suitable for drug delivery and methods relating thereto.
    상세보기

이 특허를 인용한 특허 (37)

  1. Ekwuribe, Nnochiri N.; Radhakrishnan, Balasingam, Calcitonin drug-oligomer conjugates, and uses thereof.
    상세보기
  2. Ekwuribe, Nnochiri N.; Radhakrishnan, Balasingam, Calcitonin drug-oligomer conjugates, and uses thereof.
    상세보기
  3. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Puskas, Monica; Ekwuribe, Nnochiri N., Cation complexes of insulin compound conjugates, formulation and uses thereof.
    상세보기
  4. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Puskas, Monica; Ekwuribe, Nnochiri N., Cation complexes of insulin compound conjugates, formulations and uses thereof.
    상세보기
  5. Lee, Haeshin; Lee, Hyukjin; Song, In Taek; Lee, Moon Sue, Conjugate of catechol-modified polyethylene glycol with protein or peptide and preparation method thereof.
    상세보기
  6. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Pavliv, Leo; Polowy, Karen; Puskas, Monica; Ekwuribe, Nnochiri N., Fatty acid formulations and oral delivery of proteins and peptides, and uses thereof.
    상세보기
  7. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Pavliv, Leo; Polowy, Karen; Puskas, Monica; Ekwuribe, Nnochiri N., Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof.
    상세보기
  8. Johansen, Nils Langeland; Lau, Jesper; Madsen, Kjeld; Hansen, Thomas Kruse; Sturis, Jeppe, GLP-1 compounds.
    상세보기
  9. Ekwuribe,Nnochiri N.; Price,Christopher H.; Still,James Gordon; Filbey,Jennifer Ann; Ansari,Aslam M.; Odenbaugh,Amy L.; Radhakrishnan,Balasingam, Insulin conjugates for treating diabetes mellitus.
    상세보기
  10. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Puskas, Monica E.; Ekwuribe, Nnochiri N., Insulin-oligomer conjugates, formulations and uses thereof.
    상세보기
  11. Radhakrishnan, Balasingam; Aggarwal, Diti; Ferro, Michelle; James, Kenneth D.; Malkar, Navdeep B.; Miller, Mark A.; Puskas, Monica; Ekwuribe, Nnochiri N., Insulin-oligomer conjugates, formulations and uses thereof.
    상세보기
  12. Patterson,James A., Medicament composition and method of administration.
    상세보기
  13. Still, James Gordon; Kosutic, Gordana, Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus.
    상세보기
  14. Ekwuribe, Nnochiri N.; Price, Christopher H.; Ansari, Aslam M.; Odenbaugh, Amy L., Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties.
    상세보기
  15. Ekwuribe,Nnochiri N.; Price,Christopher H.; Still,James Gordon; Filbey,Jennifer Ann, Methods of treating diabetes mellitus.
    상세보기
  16. Ekwuribe, Nnochiri N.; Price, Christopher H.; Ansari, Aslam M.; Odenbaugh, Amy L., Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  17. Ekwuribe,Nnochiri N.; Price,Christopher H.; Ansari,Aslam M.; Odenbaugh,Amy L., Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  18. Ekwuribe, Nnochiri N.; Price, Christopher H.; Ansari, Aslam M.; Odenbaugh, Amy L., Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  19. Ekwuribe, Nnochiri N.; Price, Christopher H.; Ansari, Aslam M.; Odenbaugh, Amy L., Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  20. Ekwuribe,Nnochiri N.; Price,Christopher H.; Ansari,Aslam M.; Radhakrishnan,Balasingam; Odenbaugh,Amy L., Mixtures of insulin drug-oligomer comprising polyalkylene glycol.
    상세보기
  21. Ekwuribe, Nnochiri N.; Price, Christopher H.; Ansari, Aslam M.; Radhakrishnan, Balasingam; Odenbaugh, Amy L., Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  22. Ekwuribe,Nnochiri N.; Price,Christopher H.; Ansari,Aslam M.; Radhakrishnan,Balasingam; Odenbaugh,Amy L., Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same.
    상세보기
  23. James, Kenneth D.; Radhakrishnan, Balasingam; Malkar, Navdeep B.; Miller, Mark A.; Ekwuribe, Nnochiri N., Natriuretic compounds, conjugates, and uses thereof.
    상세보기
  24. James, Kenneth D.; Radhakrishnan, Balasingham; Malkar, Navdeep B.; Miller, Mark A.; Ekwuribe, Nnochiri N., Natriuretic compounds, conjugates, and uses thereof.
    상세보기
  25. Khedkar, Anand; Rangappa, Sharath Kumar Mallapura; Subramani, Ramesh; Dave, Nitesh; Radhakrishnan, Devesh; Shankar, Sundaresh; Chivukula, Sudheer; Ramakrishna, Ranjith; Murthy, Shanmugam Thandava; Pai, Harish Venkatraman; Sengupta, Nilanjan; Melarkode, Ramakrishnan; Iyer, Harish, Orally administrable solid pharmaceutical composition and a process thereof.
    상세보기
  26. Kao, Haui-Hung; Baichwal, Anand R.; McCall, Troy; Lee, David, Oxymorphone controlled release formulations.
    상세보기
  27. Kao, Huai-Hung; Baichwal, Anand R.; McCall, Troy; Lee, David, Oxymorphone controlled release formulations.
    상세보기
  28. Min,Bon Hong; Park,Myung Ok; Kim,Min Young; Park,Byung Young; Chun,Boe Gwun; Kang,Sang Wook; Moon,Chang Hee, Pharmaceutical composition comprising arginine deiminase for inhibiting angiogenesis.
    상세보기
  29. Soltero, Richard; Radhakrishan, Balasingam; Ekwuribe, Nnochiri N.; Rehlaender, Bruce; Hickey, Anthony; Bovet, Li Li, Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith.
    상세보기
  30. Soltero,Richard; Radhakrishan,Balasingam; Ekwuribe,Nnochiri N.; Rehlaender,Bruce; Hickey,Anthony; Bovet,Li Li, Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith.
    상세보기
  31. Bossard, Mary J.; Fang, Zhihao; Viegas, Tacey X.; Thompson, Stewart A.; Kuo, Mei-chang, Polymer conjugates of GLP-1.
    상세보기
  32. Bossard, Mary J.; Fang, Zhihao; Viegas, Tacey X.; Thompson, Stewart A.; Kuo, Mei-chang, Polymer conjugates of GLP-1.
    상세보기
  33. Kausch, Annemie Rehor; Cerritelli, Simona, Polymeric tissue sealant.
    상세보기
  34. Rehor, Annemie; Cerritelli, Simona, Polymeric tissue sealant.
    상세보기
  35. Liu, Keliang; Qie, Jiankun; Yang, Zhixia; Liang, Yuanjun; Wang, Ying; Gong, Zehui; Dong, Huajin, Site-specific pegylated linear salmon calcitonin analogues.
    상세보기
  36. Baichwal,Anand R.; Kao,Huai Hung; McCall,Troy W., Sustained release formulations of oxymorphone.
    상세보기
  37. Walker, Kenneth William; Xiong, Fei, Transthyretin variants.
    상세보기

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