초록 ▼

An endoscope can undergo at least one of cleaning, disinfection, and sterilization at high temperature. The endoscope includes an elongated insertion member and a control section joined to the proximal end of the insertion member. A drop in the temperature of at least part of the outer surface of th

An endoscope can undergo at least one of cleaning, disinfection, and sterilization at high temperature. The endoscope includes an elongated insertion member and a control section joined to the proximal end of the insertion member. A drop in the temperature of at least part of the outer surface of the insertion member occurring when the endoscope is cooled to predetermined temperature after being processed at high temperature is substantially equal to or larger than a drop in the temperature of at least part of the outer surface of any member other than said part of the outer surface of the insertion member.

대표청구항 ▼

An endoscope can undergo at least one of cleaning, disinfection, and sterilization at high temperature. The endoscope includes an elongated insertion member and a control section joined to the proximal end of the insertion member. A drop in the temperature of at least part of the outer surface of th

An endoscope can undergo at least one of cleaning, disinfection, and sterilization at high temperature. The endoscope includes an elongated insertion member and a control section joined to the proximal end of the insertion member. A drop in the temperature of at least part of the outer surface of the insertion member occurring when the endoscope is cooled to predetermined temperature after being processed at high temperature is substantially equal to or larger than a drop in the temperature of at least part of the outer surface of any member other than said part of the outer surface of the insertion member. Kuriakose et al., "Interleukin-12 Delivered by Biodegradable Microspheres Promotes the Antitumor Activity of Human Peripheral Blood Lymphocytes in a Human Head and Neck Tumor Xenograft/Scid Mouse Model," Head & Neck, 57, 2000. Kubek et al., "Prolonged seizure suppression by a single implantable polymeric-TRH microdisk preparation," Brain Research, 809: 189, 1998. Kong et al., "Intralesionally Implanted Cisplatin Plus Systemic Carmustine for the Treatment of Brain Tumor in Rats," Journal of Surgical Oncology, 69: 76, 1998. Walter et al., "Interstitial Taxol Delivered from a Biodegradable Polymer Implant against Experimental Malignant Glioma1,"Cancer Research, 54: 2207, 1994. Laurencin et al., "Bioerodible Polyanhydrides for Antibiotic Drug Delivery: In Vivo Osteomyelitis Treatment in a Rat Model System," Journal of Orthopaedic Research, 11: 256, 1993. Tamargo et al., "Interstitial Chemotherapy of the 9L Gliosarcoma: Controlled Release Polymers for Drug Delivery in the Brain1,"Cancer Res., 53: 329, 1993. Fung et al., "Pharmacokinetics in Interstitial Delivery of Carmustine, 4-Hydroperoxycyclophosphamide, and Paclitaxel from a Biodegradable Polymer Implant in the Monkey Brain1," Cancer Research 58: 672, 1998. Judy et al., "Effectiveness of controlled release of a cyclophosphamide derivative with polymers against rat gliomas," J. Neurosurg, 82: 481, 1995. Brem et al., "Interstitial chemotherapy with drug polymer implants for the treatment of recurrent-gliomas," J. Neurosurg 74: 441, 1991. Park et al., "Biodegradable polyanhydride devices of cefazolin sodium, bupivacaine, and taxol for local drug delivery: preparation, and kinetics and mechanism of in vitro release," Journal of Controlled Release, 52: 179, 1998. Conforti et al., "Anti-inflammatory Activity of Polyphosphazene-based Naproxen Slow-release Systems," J. Pharm. Pharmacol, 48: 468, 1996. Straw et al., "Effects of Cis-Diammindeichloroplatinum II Released from D,L-Polylactic Acid Implanted Adjacent to Cortical Allografts in Dogs," Journal of Orthopaedic Research, 12: 871, 1994. Ringkjob, R., "Treatment of Intracranial Gliomas and Metastatic Carcinomas by Local Application of Cytostatic Agents," Aeta Neurol. Scandinav, 44: 318, 1968. Grossman et al., "The Intracerebral distribution of BCNU delivered by surgically implanted biodegradable polymers," J. Nuerosurg, 76: 640, 1992. Chattaraj et al., "Biodegradable microparticles of influenza viral vaccine: comparison of the effects of routes of administration on the in vivo immune response in mice," Journal of Controlled Release, 58: 223, 1999. Yoshida et al., "In vivo release of cisplatin from a needle-type copolymer formulation implanted in rat kidney," Biomaterials, 10:, 17, 1989. Cardinale et al., "Effect of Interstitial and/or Systemic Delivery of Tirapazamine on the Radiosensitivity of Human Glioblastoma Multiforme in Nude Mice," Radiation Oncology Investigations, 6: 63, 1998. Valtonen et al., "Interstitial Chemotherpy with Carmustine-loaded Polymers for High-grade Gliomas: A Randomized Double-blind Study," Neurosurgery, 41: 44, 1997. Yuan et al., "Implantable Polymers for Tirapazamine Treatments of Experimental Intracranial Malignant Glioma," Radiation Oncology Investigation, 7: 218, 1999. Ewend et al., "Local Delivery of Chemotherapy and Concurrent External Beam Radiotherapy Prolongs Survival in Metastatic Brain Tumor Models1,"Research, 56: 5217, 1996. Yapp et al., "Tumor Treatment by Sustained Intratumoral Release of Cisplatin: Effects of Drug Alone and Combined with Radiationl" 39:497, 1997. Yapp et al., "The Potentiation of the Effect of Radiation Treatment by Intratumoral Delivery of Cisplatin," Int. J. Radiation Oncology Biol. Phys., 42: 413, 1998. Yapp et al., "Radiosensitization of a mouse tumor model by sustained intra-tumoral release of Etanidazole and Tirapazamine using a biodegradable polymer implant device," Radiotherapy and Oncology, 53: 77, 199