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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0997808 (2001-11-29) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 928 인용 특허 : 215 |
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive sp
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive sp
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible. rein said antibody is a polyclonal antibody. 11. The method of claim 1, wherein the first receptor is bound or binds to a solid phase, said method further comprising incubating or separating one of the first and second complexes in presence of the solid phase. 12. The method of claim 11, wherein said solid phase is a wall of a reaction vessel, a sample tube, a microplate, a cuvette, or particulate material. 13. The method of claim 1, wherein the lectin is biotinylated and the marker is coupled with avidin or streptavidin. 14. The method of claim 1, wherein the marker is an enzyme. 15. The method of claim 14, wherein the enzyme is a peroxidase, alcohol dehydrogenase, glucose-6-dehydrogenase, or diaphorase. 16. The method of claim 1, wherein the marker is a fluorescent or luminescent marker. 17. The method of claim 1, wherein the human body fluid is serum or whole blood.
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