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A device for handling PCR microcards, each having an array of sample chambers closed by a transparent material on one side thereof, in relation to a PCR instrument, the device including a carrier having an apertured region with an array of holes corresponding in number and relative location with the

A device for handling PCR microcards, each having an array of sample chambers closed by a transparent material on one side thereof, in relation to a PCR instrument, the device including a carrier having an apertured region with an array of holes corresponding in number and relative location with the array of sample chambers in each of the microcards, and a provision for retaining a microcard on the carrier so that the transparent material faces the apertured region with the reagent sample chambers aligned, respectively, with the holes in the apertured region, and so that the side of the microcard opposite the transparent material is unobstructed at least throughout the array of sample chambers. The device cooperates with the PCR instrument to ensure accurate positioning of the carrier and the microcard retained thereon for real time PCR processing.

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A device for handling PCR microcards, each having an array of sample chambers closed by a transparent material on one side thereof, in relation to a PCR instrument, the device including a carrier having an apertured region with an array of holes corresponding in number and relative location with the

A device for handling PCR microcards, each having an array of sample chambers closed by a transparent material on one side thereof, in relation to a PCR instrument, the device including a carrier having an apertured region with an array of holes corresponding in number and relative location with the array of sample chambers in each of the microcards, and a provision for retaining a microcard on the carrier so that the transparent material faces the apertured region with the reagent sample chambers aligned, respectively, with the holes in the apertured region, and so that the side of the microcard opposite the transparent material is unobstructed at least throughout the array of sample chambers. The device cooperates with the PCR instrument to ensure accurate positioning of the carrier and the microcard retained thereon for real time PCR processing. Biological Chemistry vol. 270 (1995) 16167-16175. Sharma et al. "Peptide Transport by the Multidrug Resistance Pump" J. Biol. Chem. vol. 267 (1992) 5731-5734. Shen et al. "Human multidrug-resistant cell lines: Increased mdr1 expression can precede gene amplification" Science vol. 232 (1986) 643-645. Sherrington et al. "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease" Nature vol. 375 (1995) 754-760. Shinoda H. et al. "In Vivo Circumvention of Vincristine Resistance in Mice with P388 Leukemia Using a Novel Compound, AHC-52" Cancer Research vol. 49 (1989) 1722-1726. Shoji et al. "Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing," Science vol. 258 (1992) 126-129. Siman et al. "Expression of B-Amyloid precursor protein in reactive astrocytes following neuronal damage" Neuron vol. 3 (1989) 275-285. Sisodia et al. "Evidence That β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing" Science vol. 248 (1990) 492-495. Slack et al. "Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 Fibroblasts Overexpressing Pro