초록 ▼

Shaped, preferably porous, inorganic bodies are provided which are prepared from a reactive blend. In accordance with one preferred embodiment, the solution is absorbed into a porous sacrificial substrate such as a cellulose sponge. The solution-saturated substrate is heated and an oxidation-reducti

Shaped, preferably porous, inorganic bodies are provided which are prepared from a reactive blend. In accordance with one preferred embodiment, the solution is absorbed into a porous sacrificial substrate such as a cellulose sponge. The solution-saturated substrate is heated and an oxidation-reduction reaction occurs thereby forming an inorganic solid. A shaped, inorganic body is formed in situ. Optional, but preferred additional thermal treatment of the shaped, inorganic body removes the organic substrate, leaving an inorganic body that faithfully mimics the porosity, shape, and other physical characteristics of the organic substrate. Inorganic substrates may also be used to good effect. Large varieties of shaped bodies can be prepared in accordance with other embodiments of the invention and such shapes find wide use in surgery, laboratory and industrial processes and otherwise. The invention also provides chemically and morphologically uniform powders, including those having uniformly small sizes.

대표청구항 ▼

Shaped, preferably porous, inorganic bodies are provided which are prepared from a reactive blend. In accordance with one preferred embodiment, the solution is absorbed into a porous sacrificial substrate such as a cellulose sponge. The solution-saturated substrate is heated and an oxidation-reducti

Shaped, preferably porous, inorganic bodies are provided which are prepared from a reactive blend. In accordance with one preferred embodiment, the solution is absorbed into a porous sacrificial substrate such as a cellulose sponge. The solution-saturated substrate is heated and an oxidation-reduction reaction occurs thereby forming an inorganic solid. A shaped, inorganic body is formed in situ. Optional, but preferred additional thermal treatment of the shaped, inorganic body removes the organic substrate, leaving an inorganic body that faithfully mimics the porosity, shape, and other physical characteristics of the organic substrate. Inorganic substrates may also be used to good effect. Large varieties of shaped bodies can be prepared in accordance with other embodiments of the invention and such shapes find wide use in surgery, laboratory and industrial processes and otherwise. The invention also provides chemically and morphologically uniform powders, including those having uniformly small sizes. no acid sequence in SEQ. ID. NO: 11, and said CDR3' comprises the amino acid sequence in SEQ. ID. NO: 12; or said CDR1, CDR2, CDR3, CDR1', CDR2' and CDR3' taken in sequence as a whole comprise an amino acid sequence which is at least 95% identical to SEQ. ID. Nos. 7, 8, 9, 10, 11 and 12 taken in sequence as a whole. 7. A CD25 binding molecule according to claim 6 wherein said CDR1comprises the amino acid sequence in SEQ. ID. NO: 7, said CDR2 comprises the amino acid sequence in SEQ. ID. NO: 8, said CDR3 comprises the amino acid sequence in SEQ. ID. NO: 9, said CDR1' comprises the amino acid sequence in SEQ. ID. 10, said CDR2' comprises the amino acid sequence in SEQ. ID. NO: 11, and said CDR3' comprises the amino acid sequence in SEQ. ID. NO: 12. 8. A CD25 binding molecule according to claim 7 wherein said CDR1 consists of the amino acid sequence in SEQ. ID. NO: 7, said CDR2 consists of the amino acid sequence in SEQ. ID. NO: 8, said CDR3 consists of the amino acid sequence in SEQ. ID. NO: 9, said CDR1' consists of the amino acid sequence in SEQ. ID. NO: 10, said CDR2' consists of the amino acid sequence in SEQ. ID. NO: 11 and said CDR3' consists of the amino acid sequence in SEQ. ID. NO: 12. 9. A CD25 binding molecule according to claim 6 wherein the first domain comprises the amino acid sequence in SEQ. ID. NO: 3 and the second domain comprises the amino acid sequence in SEQ. ID. NO: 6. 10. A CD25 binding molecule according to claim 9 wherein the first domain consists of the amino acid sequence in SEQ. ID. NO: 3 and the second domain consists of the amino acid sequence in SEQ. ID. NO: 6. 11. A single chain CD25 binding molecule which comprises at least one antigen binding site comprising: (a) a first domain comprising in sequence hypervariable regions CDR1, CDR2 and CDR3, said hypervariable regions alternating with framework regions, (b) a second domain comprising in sequence hypervariable regions CDR1', CDR2' and CDR3', said hypervariable regions alternating with framework regions, and (c) a peptide linker which is bound either to the N-terminus of the first domain and the C-terminus of the second domain or to the C-terminus of the first domain and the N-terminus of the second domain, wherein said CDR1 comprises the amino acid sequence in SEQ. ID. NO: 7, said CDR2 comprises the amino acid sequence in SEQ. ID. NO: 8, said CDR3 comprises the amino acid sequence in SEQ. ID. NO: 9, said CDR1' comprises the amino acid sequence in SEQ. ID. 10, said CDR2' comprises the amino acid sequence in SEQ. ID. NO: 11, and said CDR3' comprises the amino acid sequence in SEQ. ID. NO: 12; or said CDR1, CDR2, CDR3, CDR1', CDR2' and CDR3' taken in sequence as a whole comprise an amino acid sequence which is at least 90% identical to SEQ. ID. Nos. 7, 8, 9, 10, 11 and 12 taken in sequence as a whole. 12. A single chain CD25 binding molecule according to claim 11 wherein said CDR1 comprises the amino acid sequence in SEQ. ID. NO: 7, said CDR2 comprises the amino acid sequence in SEQ. ID. NO: 8, said CDR3 comprises the amino acid sequence in SEQ. ID. NO: 9, said CDR1' comprises the amino acid sequence in SEQ. ID. 10, said CDR2' comprises the amino acid sequence in SEQ. ID. NO: 11, and said CDR3' comprises the amino acid sequence in SEQ. ID. NO: 12. 13. A single chain CD25 binding molecule according to claim 11 wherein the first domain comprises the amino acid sequence in SEQ. ID. NO:3 and the second domain comprises the amino acid sequence in SEQ. ID. NO:6. 14. A single chain CD25 binding molecule according to claim 13 wherein the first domain consists of the amino acid sequence in SEQ. ID. NO:3, the second domain consists of the amino acid sequence in SEQ. ID. NO:6, and the peptide linker consists of from 10 to 30 amino acids. 15. A CD25 binding molecule which comprises: (a) an immunoglobulin heavy chain or fragment thereof which comprises (i) a variable domain comprising in sequence hypervariable regions CDR1, CDR2 and CDR3, said hy