초록 ▼

A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a 20 plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a c

A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a 20 plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.

대표청구항 ▼

A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a 20 plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a c

A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a 20 plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism. le body of said insertion instrument. 7. A joint construction for an endoscopic insertion instrument as defined in claim 5, wherein said shield portion is formed by fitting a flexible tube on outer periphery of said closed sheathing coil. 8. In an endoscopic insertion instrument having a rigid tip end section with an observation window and an illumination window, an elongated flexible body, an angle section connected between said rigid tip end section and said flexible body, inner and outer connecting ring extended toward each other from meeting ends of said angle section and said flexible body and fitted one on the other in an overlapped state, said inner and outer rings being soldered together to join said angle section and said flexible body fixedly to each other: an endoscopic insertion instrument comprising: an operating wire passed through a joint portion of said connecting rings to turn said angle section into an angularly bent position; a sheathing coil coextensively provided in said flexible body and configured to encase said operating wire; an anchor pipe fixedly provided at the joint portion of said connecting rings and configured to anchor a fore end portion of said sheathing coil therein; and a fluid-tight shield portion provided around said sheathing coil over a predetermined axial length from a proximal end of said anchor pipe and extended into a helical coil structure of said flexible body to prevent intrusion of solder into said sheathing coil at the time of soldering said connecting rings together. 9. An endoscopic insertion instrument as defined in claim 8 wherein said shield portion is constituted by a seal material which is applied on outer periphery of said sheathing coil. 10. An endoscopic insertion instrument as defined in claim 8, wherein said shield portion is constituted by a flexible tube which is fitted on outer periphery of said sheathing tube. comprising: a. an elongate member having proximal and distal ends, and a lumen capable of discharging urine therethrough; and, b. a sealed flow control assembly comprising first and second fluid containing compartments adapted to be in fluid communication, said sealed flow control assembly operatively joined to said elongate member such that urine entering said elongate member impinges upon said first fluid containing compartment, said flow control assembly being responsive to increased bladder pressure such that fluid is displaced from said first fluid containing compartment to said second fluid containing compartment to thereby permit select passage of the urine entering said elongate member to said lumen thereof for discharge therethrough. 2. The device of claim 1 wherein a primary fluid passage connects said first fluid containing compartment with said second fluid containing compartment, said primary fluid passage capable of selective passage of fluid between said fluid compartments in furtherance of passage of urine from the bladder to said lumen. 3. The device of claim 2 wherein said flow control assembly further includes a latch disposed to prohibit the flow of fluid from said first fluid containing compartment to said primary fluid passage. 4. The device of claim 3 wherein said latch is capable of remote manipulation to permit displacement of fluid from said first fluid containing compartment to said second fluid containing compartment. 5. The device of claim 4 wherein said latch is magnetically activated. 6. The device of claim 5 wherein unlatching of said latch is initiated by means external to said device. 7. A urinary flow control device comprising: a. an elongate member having proximal and distal ends, and a lumen capable of discharging urine therethrough; and, b. a flow control assembly comprising first and second fluid containing compartments joined by primary and secondary fluid passages, said flow control assembly operatively joined to said elongate member and adapted to receive and contain urine from a bladder so as to impinge upon said first fluid containing compartment, said flow control assembly being responsive to increased bladder pressure such that fluid is displaced from said first fluid containing compartment to said second fluid containing compartment via said primary fluid passage to thereby permit select passage of received urine to said lumen for discharge therethrough, said a secondary fluid passage permitting fluid communication between said first fluid containing compartment with said second fluid containing compartment so as to provide automatic pressure relief to the bladder by displacement of fluid from said first fluid containing compartment to said second fluid containing compartment. 8. The device of claim 7 wherein fluid is displaced from said first fluid containing compartment to said second fluid containing compartment via said secondary fluid passage during discrete pressure impulse events transmitted by the bladder in furtherance of bladder pressure relief. 9. The device of claim 8 wherein a bladder pressure impulse of about 10 to 100 centimeters of water motivates passage of fluid from said first fluid containing compartment to said second fluid containing compartment. 10. The device of claim 8 wherein a bladder pressure impulse of about 20 to 50 centimeters of water motivates passage of fluid from said first fluid containing compartment to said second fluid containing compartment. 11. The device of claim 1 wherein said sealed flow control assembly has a static configuration and a dynamic configuration, said static configuration blocking the passage of urine from the bladder to said lumen, said dynamic configuration permitting drainage of urine from the bladder to said lumen. 12. The device of claim 11 wherein said static configuration comprises said first fluid containing compartment completely abutting an interior portion of said sealed fluid control assembly so as t