Method for microporous surface modification of implantable metallic medical articles
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IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C25D-005/48
C25F-003/00
출원번호
US-0886545
(2001-06-21)
발명자
/ 주소
Bales, Thomas O.
Jahrmarkt, Scott L.
출원인 / 주소
Syntheon, LLC
대리인 / 주소
Gordon, David P.Jacobson, David S.Gallagher, Thomas A.
인용정보
피인용 횟수 :
111인용 특허 :
9
초록▼
A process for creating surface microporosity on a titanium (or other metal) medical device includes creating a surface oxide layer on the device; placing the device, which is connected to a negative terminal of an electrical power supply, into a calcium chloride bath; connecting the positive termina
A process for creating surface microporosity on a titanium (or other metal) medical device includes creating a surface oxide layer on the device; placing the device, which is connected to a negative terminal of an electrical power supply, into a calcium chloride bath; connecting the positive terminal of the power supply to an anode immersed in or containing calcium chloride thereby forming an electrolytic cell; passing current through the cell; removing the device from the bath; and cooling and rinsing the device to remove any surface salt. If necessary, the device is etched to remove metal oxide which may have formed during the cooling process. The resulting device has a microporous surface structure. Alternatively, only a designated surface portion of a medical device is made microporous, either by applying a non-oxidizing mask, removing a portion of the oxide layer, or subtracting a portion of a microporous surface.
대표청구항▼
A process for creating surface microporosity on a titanium (or other metal) medical device includes creating a surface oxide layer on the device; placing the device, which is connected to a negative terminal of an electrical power supply, into a calcium chloride bath; connecting the positive termina
A process for creating surface microporosity on a titanium (or other metal) medical device includes creating a surface oxide layer on the device; placing the device, which is connected to a negative terminal of an electrical power supply, into a calcium chloride bath; connecting the positive terminal of the power supply to an anode immersed in or containing calcium chloride thereby forming an electrolytic cell; passing current through the cell; removing the device from the bath; and cooling and rinsing the device to remove any surface salt. If necessary, the device is etched to remove metal oxide which may have formed during the cooling process. The resulting device has a microporous surface structure. Alternatively, only a designated surface portion of a medical device is made microporous, either by applying a non-oxidizing mask, removing a portion of the oxide layer, or subtracting a portion of a microporous surface. od Flow Promotion", Stroke, vol. 27, No. 1, Jan. 1996, pp. 105-113. Marion, D. et al., "Resuscitative hypothermia", Crit. Care Med., vol. 24, No. 2 (Suppl.), Feb. 1996, pp. S81-S89. Rosomoff, H. et al., "Resuscitation from severe brain trauma", Crit. Care Med., vol. 24, No. 2 (Suppl.), Feb. 1996, pp. S48-S56. Markarian, G. et al., "Mild Hypothermia: Therapeutic Window after Experimental Cerebral Ischemia", Neurosurgery, vol. 38, No. 3, Mar. 1996, pp. 542-551. Hoffman, W. et al., "Effects of graded Hypothermia on Outcome from Brain Ischemia", Neurological Research, vol. 18, No. 2, Apr. 1996, pp. 185-189. Schwartz, A. et al., "Isolated Cerebral Hypothermia by Single Carotid Artery Perfusion of Extracorporeally Cooled Blood in Baboons", Neurosurgery, vol. 39, No. 3, Sep. 1996, pp. 577-582. Metz, C. et al., "Moderate Hypothermia in Patients with Severe Head Injury: Cerebral and Extracerebral Effects", Journal of Neurosurgery, vol. 85, No. 4, Oct. 1996, pp. 533-541. Barone, F. et al., "Brain Cooling During Transient Focal Ischemia Provides Complete Neuroprotection", Neuroscience and Biobehavioral Reviews, vol. 21, No. 1, pp. 31-44 (1997). Tisherman, S. et al., "Future Directions for Resuscitation Research. V. Ultra-advanced Life Support", Resuscitation, vol. 34, (1997), pp. 281-293. Colbourne, F. et al., "Postischemic Hypothermia: A Critical Appraisal with Implications for Clinical Treatment", Molecular Neurobiology, vol. 14, No. 3, Jun. 1997, pp. 171-201. Jessen, C. et al., "Intravascular Heat Exchanger for Conscious Goats", Pflugers Archiv European Journal of Physiology, vol. 368, (1977) pp. 263-265. A Technique for The Production of Hypothermia: Prelim. Report Charles B. Ripstein, MD, et al.: Dept of Surgery, Maimonides Hospital and State Univ.
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이 특허에 인용된 특허 (9)
Fisher Richard L. (Warren OH), Deoxidation of a refractory metal.
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Boyle, Christopher T.; Banas, Christopher E.; Marton, Denes, Implantable expandable medical devices having regions of differential mechanical properties and methods of making same.
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Palmaz, Julio C.; Sprague, Eugene A., Implantable material having patterned surface of raised elements and photochemically altered elements and method of making same.
Chandrasekaran, Chandru; Radhakrishnan, Rajesh, Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents.
Charlebois, Steven J.; Gilbertson, Leslie N.; Hawkins, Michael E.; Medlin, Dana J.; Shetty, H. Ravindranath; Zawadzki, Steven A., Method for attaching a porous metal layer to a metal substrate.
Charlebois, Steven; Gilbertson, Leslie N.; Hawkins, Michael E; Medlin, Dana; Shetty, H. Ravindranath; Zawadzki, Steven, Method for attaching a porous metal layer to a metal substrate.
Charlebois, Steven J.; Gilbertson, Leslie N.; Hawkins, Michael E.; Medlin, Dana J.; Shetty, H. Ravindranath; Zawadzki, Steven A., Method for attaching porous metal layer to a metal substrate.
Hippensteel, Gregory M.; Peek, Lawrence F.; Anderson, Jeffrey P.; Gorhe, Devendra; Allen, Steve M., Method for bonding a tantalum structure to a cobalt-alloy substrate.
Hippensteel, Gregory M.; Peek, Lawrence F.; Anderson, Jeffrey P.; Gorhe, Devendra; Allen, Steve M.; Scrafton, Joel G.; Harmon, Casey, Method for bonding a tantalum structure to a cobalt-alloy substrate.
Owens, Gary K.; Wamhoff, Brian R.; Hudson, Matthew S.; Lye, Whye-Kei; Spradlin, Joshua; Reed, Michael; Looi, Kareen, Method for loading nanoporous layers with therapeutic agent.
Lye, Whye-Kei; Owens, Gary K.; Wamhoff, Brian R.; Hudson, Matthew S.; Spradlin, Joshua; Looi, Kareen, Methods for using a stent having nanoporous layers.
Atanasoska, Liliana; Shippy, III, James Lee; Holman, Tom; Arney, Michael S.; Schoenle, Victor; Genovese, Frank; Feng, James Q.; Flanagan, Aiden; Weber, Jan, Self-buffering medical implants.
Scheuermann, Torsten; Weber, Jan; Deng, Charles; Stinson, Jonathan S.; Larsen, Steven R.; Boismier, Dennis A.; Edick, Jacob D., Surface treated bioerodible metal endoprostheses.
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