초록 ▼

A process is provided for the stabilization of polychlorinated alkanes against dehydrochlorination. The process comprises adding a phenol compound to a polychlorinated alkane such that the dehydrochlorination of the polychlorinated alkane is suppressed when heated in the presence of iron(III). In a

A process is provided for the stabilization of polychlorinated alkanes against dehydrochlorination. The process comprises adding a phenol compound to a polychlorinated alkane such that the dehydrochlorination of the polychlorinated alkane is suppressed when heated in the presence of iron(III). In a preferred embodiment, the process comprises the prevention or reduction of dehydrochlorination of 1,1,1,3,3-pentachloropropane when heated in the presence of iron(III) contamination by the addition of monomethyl ether hydroquinone. In another embodiment, the long term storage stability of polychlorinated alkanes against dehydrochlorination is improved due to the addition of a phenol compound.

대표청구항 ▼

A process is provided for the stabilization of polychlorinated alkanes against dehydrochlorination. The process comprises adding a phenol compound to a polychlorinated alkane such that the dehydrochlorination of the polychlorinated alkane is suppressed when heated in the presence of iron(III). In a

A process is provided for the stabilization of polychlorinated alkanes against dehydrochlorination. The process comprises adding a phenol compound to a polychlorinated alkane such that the dehydrochlorination of the polychlorinated alkane is suppressed when heated in the presence of iron(III). In a preferred embodiment, the process comprises the prevention or reduction of dehydrochlorination of 1,1,1,3,3-pentachloropropane when heated in the presence of iron(III) contamination by the addition of monomethyl ether hydroquinone. In another embodiment, the long term storage stability of polychlorinated alkanes against dehydrochlorination is improved due to the addition of a phenol compound. ter content of 17.0＿20.0 wt % and being in the state of the mixture of trihydrate and tetrahydrate is prepared by neutralizing pamidronic acid with sodium compound, drying the formed disodium pamidronate, dissolving the disodium pamidronate in water, filtering sparingly soluble materials, allowing the filtrate to stand with stirring at normal temperature to form crystals, cooling and filtering the mixture to obtain crystals, and drying at the temperature of 75＿85° C. under normal pressure. The novel disodium pamidronate 3＿4 hydrate according to the present invention is much more stable compound structurally than the known disodium pamidronate pentahydrate. When the compound is in storage or is used as pharmaceutical formulations, validity time can be prolonged and it can be formulated as convenient oral preparations such as soft capsule in addition to injections.