[특허]Apparatus for preparing microparticles using in-line solvent extraction

[미국특허] Apparatus for preparing microparticles using in-line solvent extraction 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	B01F-015/02
출원번호	US-0930450 (2001-08-16)
발명자 / 주소	Lyons, Shawn L. Wright, Steven G.
출원인 / 주소	Alkermes Controlled Therapeutics Inc. II
대리인 / 주소	Reister, Andrea G.Covington & Burling
인용정보	피인용 횟수 : 17 인용 특허 : 31

초록 ▼

Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending static mixer is combined with additional extraction liquid. The additional extraction liquid and the outflow of the blending static mixer can be combined in a vessel, or through the use of a static mixer manifold that includes a plurality of static mixers.

대표청구항 ▼

1. A system for preparing microparticles, comprising: an organic phase source; a continuous phase source; an extraction liquid source; a first pump in fluid communication with said organic phase source; a second pump in fluid communication with said continuous phase source; a first static mixer in fluid communication with said first pump and with said second pump, wherein said first pump is configured to pump organic phase from said organic phase source into said first static mixer, and said second pump is configured to pump continuous phase from said continuous phase source into said first static mixer; a manifold in fluid communication with said first static mixer, said manifold comprising a plurality of individual static mixers configured to form a plurality of parallel flow streams, each of said plurality of parallel flow streams comprising at least one of said plurality of individual static mixers; a third pump in fluid communication with said manifold, wherein said third pump is configured to pump extraction liquid from said extraction liquid source; and a second static mixer in fluid communication with said manifold, wherein an outflow of said first static mixer and the extraction liquid flow through said manifold through said plurality of parallel flow streams and then through said second static mixer. 2. The system of claim 1, further comprising: a vessel in fluid communication with said second static mixer, wherein an outflow of said second static mixer flows into said vessel. 3. The system of claim 1, further comprising: a fourth pump in fluid communication with said second static mixer, wherein said fourth pump is configured to pump the extraction liquid from said extraction liquid source into said second static mixer. 4. The system of claim 3, wherein said fourth pump is configured to operate at a flow rate greater than a flow rate of said third pump. 5. The system of claim 1, further comprising: a third static mixer in fluid communication with said first static mixer and with said manifold, wherein the outflow of said first static mixer and extraction liquid from said extraction liquid source flow through said third static mixer prior to flowing through said manifold. 6. A system for preparing microparticles, comprising: an organic phase source; a continuous phase source; an extraction liquid source; a first pump in fluid communication with said organic phase source; a second pump in fluid communication with said continuous phase source; a first static mixer in fluid communication with said first pump and with said second pump, wherein said first pump is configured to pump organic phase from said organic phase source into said first static mixer, and said second pump is configured to pump continuous phase from said continuous phase source into said first static mixer; a second static mixer in fluid communication with said first static mixer; a third pump in fluid communication with said second static mixer, wherein said third pump is configured to pump extraction liquid from said extraction liquid source; and wherein an outflow of said first static mixer and the extraction liquid flow through said second static mixer. 7. The system of claim 6, further comprising: a vessel in fluid communication with said second static mixer, wherein an outflow of said second static mixer flows into said vessel. 8. The system of claim 7, wherein said vessel is a second extraction liquid source. 9. The system of claim 8, wherein said second extraction liquid is different from the extraction liquid. 10. The system of claim 6, wherein said second static mixer is configured as a manifold that comprises a plurality of static mixers arranged in parallel. 11. The system of claim 6, wherein said second static mixer is configured as a manifold that comprises a plurality of static mixers.

이 특허에 인용된 특허 (31) 인용/피인용 타임라인 분석

Lyons Shawn L. ; Wright Steven G., Apparatus and method for preparing microparticles.
상세보기
Shawn L. Lyons ; Steven G. Wright, Apparatus and method for preparing microparticles.
상세보기
Wilke Werner (Starnberg DEX) Gref Hans (Cologne DEX) Frenken Hans (Odenthal-Osenau DEX), Apparatus for the continuous preparation of photographic emulsions.
상세보기
Thanoo Bagavathikanun Chithambara ; Murtagh James, Continuous microsphere process.
상세보기
Mag Theodore K. (King City CAX) Reid Margaret P. (Don Mills CAX), Continuous process and apparatus for adsorbent bleaching of triglyceride oils.
상세보기
Sparks Randall T. (Gainesville GA) Geoghegan Edward J. (Athlone IEX), Controlled release powder and process for its preparation.
상세보기
Labrie Fernand (Quebec CAX) Lepage Martin (Quebec CAX), Controlled release systems and low dose androgens.
상세보기
Gibson John W. ; Holl Richard J. ; Tipton Arthur J., Emulsion-based processes for making microparticles.
상세보기
Payne Richard L. (McKinney TX), Fluid distribution system and method utilizing a radial splitter.
상세보기
Tice Thomas R. (Birmingham AL) Lewis Danny H. (Gardendale AL) Cowsar Donald R. (Birmingham AL) Beck Lee R. (Birmingham AL), Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents.
상세보기
Ciuti Brunello (San Donato Milanese IT) Angelini Ferdinando (Milan IT) Brandolese Ernesto (Grafignana IT), Method for the preparation in a continuous way of water/oil emulsions and apparatus suitable therefor.
상세보기
Mesens Jean (Wechelderzande BEX) Rickey Michael E. (Loveland OH) Atkins Thomas J. (Cincinnati OH), Method of inhibiting neurotransmitter activity using microencapsulated 3-piperidiny2-substituted 1,2-benzisoxazoles and.
상세보기
Naito Kenji (Odawara JPX) Ohe Keitaro (Odawara JPX) Tsuji Nobuo (Minami-ashigara JPX), Method of producing finely divided polymer particles.
상세보기
Mesens Jean,BEX ; Rickey Michael E. ; Atkins Thomas J., Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles 1,2-benzisothiazoles.
상세보기
Mesens Jean,BEX ; Rickey Michael E. ; Atkins Thomas J., Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles.
상세보기
Tice Thomas R. (Helena AL) Lewis Danny H. (Gardendale AL), Microencapsulation process.
상세보기
Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL), Microencapsulation process and products therefrom.
상세보기
Morishima Yasushi (836 ; Aza Mori ; Kokuba 1-chome Otsu JA) Miyazaki Yukifusa (550 ; Aza Iwaden ; Yabase-cho Kusatsu JA), Mixing device and element therefor.
상세보기
Herbert Paul F. (Wayland MA) Hazrati Azar M. (Maineville OH), Preparation of biodegradable microparticles containing a biologically active agent.
상세보기
Ramstack J. Michael (Lebanon OH) Herbert Paul F. (Wayland MA) Strobel Jan (Westchester OH) Atkins Thomas J. (Cincinnati OH), Preparation of biodegradable microparticles containing a biologically active agent.
상세보기
Rickey Michael E. ; Ramstack J. Michael ; Lewis Danny H., Preparation of biodegradable, biocompatible microparticles containing a biologically active agent.
상세보기
Rickey Michael E. ; Ramstack J. Michael ; Lewis Danny H. ; Mesens Jean,BEX, Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent.
상세보기
Wantier Henri (Dour BEX) Mathieu Fabienne (Nivelles BEX) Baudrihaye Marc (Waterloo BEX) Delacroix Dominique (Kraainem BEX), Preparation of microparticles for controlled release of water-soluble substances.
상세보기
Morishita Masataka (Shizuoka JA) Inaba Yoshihito (Shizuoka JA) Fukushima Mitsuru (Shizuoka JA) Hattori Yoshinori (Shizuoka JA) Kobari Sadami (Shizuoka JA) Matsuda Tetsuo (Shizuoka JA), Process for encapsulation of medicaments.
상세보기
Komen Joseph (Eb Haarlem NLX) Groenendaal Jan W. (EE Delft NLX), Process for microencapsulation.
상세보기
Fong, Jones W., Process for preparation of microspheres.
상세보기
Wilke Werner (Starnberg DEX) Gref Hans (Cologne DEX) Frenken Hans (Odenthal-Osenau DEX), Process for the continuous preparation of photographic emulsions.
상세보기
Stoisits Richard F. (Anchorage AK) Kolpak Miroslav M. (Arlington TX) Krist Gordon J. (Anchorage AK) Ma Tuan D. (Anchorage AK) Payne Richard L. (Mckinney TX) Rugen Jeffry A. (Eagle River AK) Schwarz A, Simultaneous water and gas injection into earth formations.
상세보기
Brickhouse Paul E. (Houston TX) Durrett Michael G. (Houston TX) Hatton Gregory J. (Houston TX), Static mixing system with high turndown ratios to minimize pressure drops.
상세보기
Kino Shigemi,JPX ; Osajima Tomonori,JPX ; Mizuta Hiroaki,JPX, Sustained release microsphere preparation containing antipsychotic drug.
상세보기
Kino Shigemi (Fukuoka JPX) Osajima Tomonori (Fukuoka JPX) Mizuta Hiroaki (Fukuoka JPX), Sustained release microsphere preparation containing antipsychotic drug and production process thereof.
상세보기

이 특허를 인용한 특허 (17) 인용/피인용 타임라인 분석

Lyons,Shawn L.; Wright,Steven G., Apparatus and method for preparing microparticles using in-line solvent extraction.
상세보기
Chattopadhyay, Pratibhash; Shekunov, Boris Y.; Seitzinger, Jeffrey S.; Huff, Robert W., Composite particles and method for preparing.
상세보기
McLaughlin, Jon Kevin; Williams, Roger Phillip, Control system for and method of combining materials.
상세보기
McLaughlin, Jon Kevin; Williams, Roger Phillip, Control system for and method of combining materials.
상세보기
Williams, Roger Phillip; McLaughlin, Jon Kevin, Control system for and method of combining materials.
상세보기
Williams, Roger Phillip; McLaughlin, Jon Kevin, Control system for and method of combining materials.
상세보기
Markland, Peter; Winchester, Gary Anthony; Tice, Thomas Robert; Martin, David P., Injectable delivery of microparticles and compositions therefore.
상세보기
Chattopadhyay,Pratibhash; Shekunov,Boris Y.; Seitzinger,Jeffrey S., Method and apparatus for continuous particle production using supercritical fluid.
상세보기
Lyons, Shawn L.; Wright, Steven G., Method and apparatus for preparing microparticles using in-line solvent extraction.
상세보기
Lyons, Shawn L.; Wright, Steven G., Method and apparatus for preparing microparticles using in-line solvent extraction.
상세보기
Lyons,Shawn L.; Wright,Steven G., Method and apparatus for preparing microparticles using in-line solvent extraction.
상세보기
Shekunov, Boris Y.; Chattopadhyay, Pratibhash; Huff, Robert W., Method for producing solid-lipid composite drug particles.
상세보기
Greter, Andy; Vukic, Mathey, Mixing apparatus for producing a mixture composed of at least three components.
상세보기
Walter, Dirk; Budin, Richard; Weigl, Klaus; Ganzmann, Ingo, Mixing system.
상세보기
Smith, Robert S., Motionless mixing device having primary and secondary feed ports.
상세보기
Chattopadhyay,Pratibhash; Shekunov,Boris Y.; Seitzinger,Jeffrey S.; Huff,Robert W., Particles from supercritical fluid extraction of emulsion.
상세보기
Biggs, Danielle; Nettles, Heather, Process for preparing microparticles having a low residual solvent volume.
상세보기

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 특허

해당 특허가 속한 카테고리에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

[미국특허] Apparatus for preparing microparticles using in-line solvent extraction 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

이 특허에 인용된 특허 (31) 인용/피인용 타임라인 분석

이 특허를 인용한 특허 (17) 인용/피인용 타임라인 분석

활용도 분석정보

활용도 Top5 특허

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

이 특허와 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

[미국특허] Apparatus for preparing microparticles using in-line solvent extraction 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

이 특허에 인용된 특허 (31) 인용/피인용 타임라인 분석

이 특허를 인용한 특허 (17) 인용/피인용 타임라인 분석

활용도 분석정보

활용도 Top5 특허 더보기

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

이 특허와 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

활용도 Top5 특허