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Inhibitors of the bitter taste response 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-049/00
출원번호 US-0470467 (1999-12-22)
발명자 / 주소
  • Margolskee, Robert F.
  • Ming, Ding
출원인 / 주소
  • Mount Sinai School of Medicine of New York University
대리인 / 주소
    Hedman & Costigan, P.C.
인용정보 피인용 횟수 : 83  인용 특허 : 0

초록

The present invention relates to methods for identifying inhibitors of the bitter taste response, and by methods of using such inhibitors to either block the perception of bitterness and/or promote the perception of a sweet taste. The inhibitors of the invention may be used as flavor enhancers in fo

대표청구항

The present invention relates to methods for identifying inhibitors of the bitter taste response, and by methods of using such inhibitors to either block the perception of bitterness and/or promote the perception of a sweet taste. The inhibitors of the invention may be used as flavor enhancers in fo

이 특허를 인용한 특허 (83)

  1. Budd,Kenton D.; Thalacker,Jason P.; Mitra,Sumita B.; Kolb,Brant U.; Kangas,Lani S., Acid-reactive dental fillers, compositions, and methods.
  2. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiadong; O'Connell, Shawn; Staszewski, Lena, Assays that detect T1R expressing cells.
  3. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiadong; O'Connell, Shawn; Staszewski, Lena, Binding and functional assays that use the T1R3 receptor to screen for taste modulatory compounds.
  4. Adler,Jon Elliot; Li,Xiaodong; Staszewski,Lena; O'Connell,Shawn; Zozulya,Sergey, Binding assays that use human T1R2 to identify potential taste modulators.
  5. Zoller,Mark; Li,Xiaodong; Staszewski,Lena; O'Connell,Shawn; Zozulya,Sergey; Adler,Jon Elliot; Xu,Hong; Echeverri,Fernando, Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste.
  6. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste.
  7. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Cell lines expressing T1R2/T1R3 hetero-oligomeric taste receptors and assay system thereof for identification of taste compounds.
  8. Zoller,Mark; Li,Xiaodong; Staszewski,Lena; O'Connell,Shawn; Zozulya,Sergey; Adler,Jon Elliot; Xu,Hong; Echeverri,Fernando, Cell lines that stably or transiently express a functional sweet (T1R2/T1R3) taste receptor.
  9. Zoller,Mark; Li,Xiaodong; Staszewski,Lena; O'Connell,Shawn; Zozulya,Sergey; Adler,Jon Elliot; Xu,Hong; Echeverri,Fernando, Cell lines that stably or transiently express a functional umami (T1R1/T1R3) taste receptor.
  10. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiadong; O'Connell, Shawn; Staszewski, Lena, Chimeric T1R1 taste receptor encoding nucleic acid sequences and vectors.
  11. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiadong; O'Connell, Shawn; Staszewski, Lena, Chimeric T1R1 taste receptor encoding nucleic acid sequences and vectors.
  12. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiaodong; O'Connell, Shawn; Staszewski, Lena, Chimeric human T1R1 taste receptor polypeptides and compositions containing same.
  13. Adler, Jon Elliott; Zozulya, Sergey; Li, Xiadong; O'Connell, Shawn; Staszewski, Lena, Chimeric human T1R3 taste receptor polypeptides and compositions containing same.
  14. Salemme,Francis Raymond; Barndt,Richard, Compositions and methods for producing a salty taste in foods or beverages.
  15. Salemme,Francis Raymond; Bakal,Abraham I.; Barndt,Richard, Compositions and methods for producing flavored seasonings that contain reduced quantities of common salt.
  16. Prakash, Indra; DuBois, Grant E., Condiments with high-potency sweetener.
  17. Kangas,Lani S.; Bui,Hoa T.; Thalacker,Jason P.; Kolb,Brant U.; Oxman,Joel D.; Rolf,Jacqueline C., Dental compositions containing nanofillers and related methods.
  18. Kangas,Lani S.; Bui,Hoa T.; Thalacker,Jason P.; Kolb,Brant U.; Oxman,Joel D.; Rolf,Jacqueline C., Dental compositions containing nanofillers and related methods.
  19. Kolb, Brant U.; Bui, Hoa T.; Thalacker, Jason P.; Kangas, Lani S.; Oxman, Joel D.; Budd, Kenton D.; Rolf, Jacqueline C.; Mitra, Sumita B., Dental compositions containing nanozirconia fillers.
  20. Adler, Jon Elliot; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey, Detection of cells expressing T1R2 taste receptor.
  21. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiaodong; O'Connell, Shawn; Staszewski, Lena, Detection of human T1R expressing cells.
  22. Zoller,Mark; Li,Xiaodong; Staszewski,Lena; O'Connell,Shawn; Zozulya,Sergey; Adler,Jon Elliot; Xu,Hong; Echeverri,Fernando, Functional assays for identifying compounds that modulate T1R1/T1R3 (umami) taste.
  23. Zoller,Mark; Li,Xiaodong; Staszewski,Lena; O'Connell,Shawn; Zozulya,Sergey; Adler,Jon Elliot; Xu,Hong; Echeverri,Fernando, Functional assays for identifying compounds that modulate T1R2/T1R3 (sweet) taste.
  24. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiadong; O'Connell, Shawn; Staszewski, Lena, Functional assays that use the T1R1 receptor to screen for T1R1-associated taste modulators.
  25. Adler, Jon Elliot; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey, Functional assays that use the T1R2 taste receptor to identify potential taste modulators.
  26. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Heteromeric T1R2/T1R3 taste receptors.
  27. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Heteromeric taste receptors comprising T1R2/T1R3 domains.
  28. Zoller,Mark; Li,Xiaodong; Staszewski,Lena; O'Connell,Shawn; Zozulya,Sergey; Adler,Jon Elliot; Xu,Hong; Echeverri,Fernando, Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same.
  29. Prakash, Indra; DuBois, Grant E., High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith.
  30. Adler, Jon Elliot; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey, Human T1R2 nucleic acid sequences and polypeptides.
  31. Adler, Jon Elliot; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey, Human T1R2 polypeptide functional assays.
  32. Adler, Jon Elliot; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey, Human T1R2 taste receptor nucleic acids and cells containing these nucleic acids.
  33. Adler, Jon Elliot; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey, Human T1R2 taste receptor polypeptides.
  34. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Alder, Jon Elliot; Xu, Hong; Echeverri, Fernando, In vitro method using hetero-oligomeric T1R1/T1R3 taste receptors to identify umami tastants.
  35. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, In vitro methods of detecting cells sensitive to sweet tastants by detecting expression of hetero-oligomeric T1R2/T1R3 taste receptors.
  36. Zoller,Mark; Li,Xiaodong; Staszewski,Lena; O'Connell,Shawn; Zozulya,Sergey; Adler,Jon Elliot; Xu,Hong; Echeverri,Fernando, Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli.
  37. Zoller,Mark; Li,Xiaodong; Staszewski,Lena; O'Connell,Shawn; Zozulya,Sergey; Adler,Jon Elliot; Xu,Hong; Echeverri,Fernando, Isolated (T1R2/T1R3) sweet taste receptors that respond to sweet taste stimuli.
  38. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Methods of detecting T1R hetero-oligomeric taste receptor expression to identify cells that are potentially sensitive to sweet tastants.
  39. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Femando, Methods of detecting T1R2- and T1R3-expressing cells potentially sensitive to sweet tastants.
  40. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Methods of detecting umami tastant-sensitive cells which express heteromeric T1R1/T1R3 receptors.
  41. Adler, Jon E.; Li, Xiaodong; Staszewski, Lena; Xu, Hong; Echeverri, Fernando, Methods of indentifying sweet taste modulators.
  42. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Methods of inhibiting T1R1/T1R3 heteromeric umami taste receptors.
  43. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Methods of quantifying taste of compounds for food or beverages.
  44. Adler, Jon E.; Li, Xiaodong; Luukkonen, Lena; Xu, Hong; Echeverri, Fernando, Methods of screening T1R hetero-oligomeric taste receptors for sweet taste modulators.
  45. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Methods of screening T1R1/T1R3 heteromeric receptors for compounds that modulate umami taste signaling.
  46. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Methods of screening T1R1/T1R3 heteromeric receptors for compounds that modulate umami taste signaling.
  47. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Methods of screening T1R1/T1R3 receptors for compounds that modulate umami taste signaling.
  48. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Methods of screening T1R1/T1R3 receptors for compounds that modulate umami taste signaling.
  49. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Methods of screening T1R2/T1R3 receptors for compounds which modulate sweet taste signaling.
  50. Adler,Jon Elliot; Li,Xiaodong; Staszewski,Lena; Xu,Hong; Echeverri,Fernando, Methods of screening compounds using a T1R3 hetero-oligomeric taste receptor.
  51. Adler, Jon E.; Li, Xiaodong; Staszewski, Lena; Xu, Hong; Echeverri, Fernando, Methods of screening heteromeric T1R2/T1R3 receptors for compounds which modulate sweet taste signaling.
  52. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Methods of screening heteromeric T1R2/T1R3 receptors which modulate sweet taste signaling.
  53. Adler, Jon E.; Li, Xiaodong; Luukkonen, Lena; Xu, Hong; Echeverri, Fernando, Methods of using TIR hetero-oligomeric receptors for screening compounds that modulate sweet or umami taste.
  54. Radhakrishna, Harish; Brown, Michael D.; Siderovski, David Peter; Kimple, Adam; Cohen, Staci Padove, Methods of using lung or bronchial epithelial cells to identify bitter taste modulators.
  55. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiadong; O'Connell, Shawn; Staszewski, Lena, Nucleic acid sequence and vectors encoding chimeric human T1R3 taste receptor.
  56. Drayna, Dennis; Kim, Un-Kyung; Leppert, Mark, Phenylthiocarbamide (PTC) taste receptor.
  57. Drayna, Dennis; Kim, Un-Kyung; Leppert, Mark, Phenylthiocarbamide (PTC) taste receptor.
  58. Drayna,Dennis; Kim,Un Kyung; Leppert,Mark, Phenylthiocarbamide (PTC) taste receptor.
  59. Zoller,Mark; Li,Xiaodong; Staszewski,Lena; O'Connell,Shawn; Zozulya,Sergey; Adler,Jon Elliot; Xu,Hong; Echeverri,Fernando, Recombinant methods for expressing a functional sweet (T1R2/T1R3) taste receptor.
  60. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Femando, Recombinant methods for expressing a functional umami (T1R1/T1R3) taste receptor.
  61. Servant, Guy; Servant, Nicole, Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives.
  62. Adler, Jon Elliot; Li, Xiaodong; Luukkonen, Lena; O'Connell, Shawn; Zozulya, Sergey, T1R taste receptors and genes encoding same.
  63. Adler, Jon Elliot; Li, Xiaodong; Luukkonen, Lena; O'Connell, Shawn; Zozulya, Sergey, T1R taste receptors and genes encoding same.
  64. Adler, Jon Elliot; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey, T1R taste receptors and genes encoding same.
  65. Adler, Jon Elliot; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey, T1R taste receptors and genes encoding same.
  66. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiaodong; O'Connell, Shawn; Luukkonen, Lena, T1R taste receptors and genes encoding same.
  67. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiaodong; O'Connell, Shawn; Luukkonen, Lena, T1R taste receptors and genes encoding same.
  68. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiaodong; O'Connell, Shawn; Staszewski, Lena, T1R taste receptors and genes encoding same.
  69. Adler, Jon Elliott; Li, Xiaondong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey, T1R taste receptors and genes encoding same.
  70. Adler,Jon Elliot; Zozulya,Sergey; Li,Xiadong; O'Connell,Shawn; Staszewski,Lena, T1R taste receptors and genes encoding same.
  71. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiadong; O'Connell, Shawn; Staszewski, Lena, T1R1 nucleic acid sequences and vectors containing same.
  72. Adler,Jon Elliot; Zozulya,Sergey; Li,Xiadong; O'Connell,Shawn; Staszewski,Lena, T1R1 receptor binding assays for identification of taste modulators.
  73. Adler, Jon Elliot; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey, T1R2 binding assays.
  74. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiadong; O'Connell, Shawn; Staszewski, Lena, T1R3 binding assays.
  75. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiadong; O'Connell, Shawn; Staszewski, Lena, T1R3 nucleic acid fragments for use thereof as probes and for generating T1R specific antibodies.
  76. Adler, Jon Elliott; Zozulya, Sergey; Li, Xiaondong; O'Connell, Shawn; Staszewski, Lena, T1R3 receptor binding assays for identification of T1R3 modulatory compounds.
  77. Windschauer, Robert J.; Virgallito, Teresa T., Taste masking compositions and edible forms thereof for masking the taste of foods.
  78. Adler, Jon Elliot; Li, Xiaodong; Staszewski, Lena; Xu, Hong; Echeverri, Fernando, Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling.
  79. Lee, S. Paul; Zhou, Peihong; Buber, M. N. Tulu; Cerne, Rok; Bryant, Robert; Salemme, F. Raymond; Morgan, Gillian, Use of a TRPM5 inhibitor to regulate insulin and GLP-1 release.
  80. Craig,Bradley D.; Kolb,Brant U.; Oxman,Joel D.; Peez,Robert F.; Frank,Sybille A., Use of nanoparticles to adjust refractive index of dental compositions.
  81. Drayna, Dennis; Kim, Un Kyung, Variants of human taste receptor genes.
  82. Drayna, Dennis; Kim, Un-Kyung, Variants of human taste receptor genes.
  83. Drayna, Dennis; Kim, Un-Kyung, Variants of human taste receptor genes.
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