초록 ▼

Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including int

Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

대표청구항 ▼

1. A biodegradable polyhydroxyalkanoate composition comprising a polyhydroxyalkanoate polymer having a controlled degradation rate of less than one year in vivo, under physiological conditions, wherein the degradation rate of the polyhydroxyalkanoate polymer is manipulated through addition of compon

1. A biodegradable polyhydroxyalkanoate composition comprising a polyhydroxyalkanoate polymer having a controlled degradation rate of less than one year in vivo, under physiological conditions, wherein the degradation rate of the polyhydroxyalkanoate polymer is manipulated through addition of components to the polymeric composition, selection of the chemical composition of the polyhydroxyalkanoate polymer through selection of monomeric units, as chemical linkages, which are incorporated into the polymer, by alteration of the linkages, chemical backbone or pendant groups, molecular weight, processing conditions, or form of the composition, and wherein the polyhydroxyalkanoate polymer has a weight average molecular weight of between 10,000 and 10,000,000 Dalton; and wherein the form of the composition refers to the porousness and surface area of the composition. 2. The composition of claim 1 wherein the chemical composition of the polyhydroxyalkanoate is altered by alteration of the linkages, or chemical backbone or pendant groups. 3. The composition of claim 1 wherein the polyhydroxyalkanoate polymer is selected from the group of consisting of poly-4-hydroxybutyrate, poly-4-hydroxybutyrate-co-3-hydroxybutyrate, poly-4-hydroxybutyrate-co-2-hydroxybutyrate, and copolymers and blends thereof. 4. The composition of claim 1 wherein the polyhydroxyalkanoate polymer is selected from the group consisting of poly-3-hydroxybutyrate-co-3-hydroxyhexanoate, poly-3-hydroxybutyrate-co-3-hydroxyoctanoate, poly-3-hydroxybutryrate-co-3-hydroxydecanoate, and copolymers and blends thereof. 5. The composition of claim 1 wherein the polyhydroxyalkanoate polymer comprises one or more units which alter the chemical stability of the polymer backbone. 6. The composition of claim 1 wherein the polyhydroxyalkanoate polymer comprises unit(s) promoting chain scission. 7. The composition of claim 6 wherein the units contain more than two functional groups. 8. The composition of claim 1 wherein a heteroatom is incorporated into the polymer backbone chain. 9. The composition of claim 8 wherein the heteroatom is selected from the group consisting of oxygen, sulfur or nitrogen. 10. The composition of claim 6 wherein the units are incorporated into the polymer backbone with chemical linkages selected from the group consisting of ester, amide, ether, carbamate, anhydride, and carbonate. 11. The composition of claim 10 wherein the units are selected from the group consisting of 2-hydroxyacids, 2-hydroxyalkoxyacetic acids, amino acids, amino alcohols, diacids, triols, and tetraols. 12. The composition of claim 11 wherein the 2-hydroxyacids are 2-hydroxyalkanoic acids. 13. The composition of claim 12 wherein the 2-hydroxyalkanoic acid is lactic acid or glycolic acid. 14. The composition of claim 11 wherein the 2-hydroxyacids are 2-hydroxyalkenoic acids. 15. The composition of claim 11 wherein the 2-hydroxyalkoxyacetic acids are selected from the group consisting of 2-hydroxyethoxy acetic acid and 3-hydroxypropoxy acetic acid. 16. The composition of claim 1 wherein the polymer comprises pendant groups that catalyze the degradation of the polymer backbone. 17. The composition of claim 16 wherein the pendant groups are selected from acidic and basic groups. 18. The composition of claim 16 comprising reactant pendant groups that cause polymer chain scission. 19. The composition of claim 18 wherein the reactant pendant groups are selected from nucleophiles and electrophiles. 20. The composition of claim 16 wherein the pendant groups are selected from the group consisting of alcohols, acids, and amine groups.