초록 ▼

A process for hydroxylating aliphatic compounds under catalytic distillation conditions to provide alcohols is provided. The aliphatic compound is contacted, in a distillation column reactor, with an oxidation catalyst and an oxidant under conditions effective to hydroxylate the aliphatic compound w

A process for hydroxylating aliphatic compounds under catalytic distillation conditions to provide alcohols is provided. The aliphatic compound is contacted, in a distillation column reactor, with an oxidation catalyst and an oxidant under conditions effective to hydroxylate the aliphatic compound while maintaining at least a portion of the aliphatic compound in a liquid phase and separating the hydroxylated product from the un-reacted aliphatic compound in the distillation column reactor.

대표청구항 ▼

A process for hydroxylating aliphatic compounds under catalytic distillation conditions to provide alcohols is provided. The aliphatic compound is contacted, in a distillation column reactor, with an oxidation catalyst and an oxidant under conditions effective to hydroxylate the aliphatic compound w

A process for hydroxylating aliphatic compounds under catalytic distillation conditions to provide alcohols is provided. The aliphatic compound is contacted, in a distillation column reactor, with an oxidation catalyst and an oxidant under conditions effective to hydroxylate the aliphatic compound while maintaining at least a portion of the aliphatic compound in a liquid phase and separating the hydroxylated product from the un-reacted aliphatic compound in the distillation column reactor. z, C.G. et al., Immunol. Lett. 32, 7-12 (1992). Parthasarathy, S. et al., Probucol Inhibits Oxifative Modification of Low Density Lipoprotein, J. Clin. Invest., 77 641-644 (1986). Patton et al., Clin. Chem. 29, 1980 (1983). Pilewski, J.M., et al , Am. J. Respir. Cell Mol. Biol. 12, 1-3 (1995). Rabb, A. et al., Am J. Respir. Care Med. 149, 1186+1191 (1994). Steinberg, et al., Modifications of Low-Density Lipoprotein That Increases its. Yang, X.D. et al., Proc. Natl. Acad. Sci. U.S.A. 90,, 10494-10498 (1993. Chemical Abstracts 127:75973, 1996. Chemical Abstracts 82:86196, 1975. Chemical Abstracts 126:277465, 1997. Chemical Abstracts 94:30290, 1980. Chemical Abstracts 86:5066, 1977. Chemical Abstracts 122:187387, 1995. Chemical Abstracts 124:146082, 1995. Chemical Abstracts 110:212254, 1989. Chemical Abstracts Service, Columbus, Ohio, US; STN, accession No. 124:8690, XP002115603; see abstract; Chemical Abstracts, vol. 124, No. 1, Jan. 1, 1996; Columbus, Ohio, US; abstract No. 8690, XP002115596; abstract & V.I. Kelarev et al: Khim. Geterotsikl. Soedin,; No. 4, 1995, pp. 514-517. Feldman, Davis, et al., The In Vitro and Ex Vivo Antioxidant Properties, and Hypolipidemic Activity of CGP 2881; Atherosclerosis, Dec. 28, 1998 vol. 144, 343-355. Fruebis, Joachim, A Conparsion of the Antiatherogenic Effects of Probucol and of a Structural Analogue of Probucol in Low Density Lipoprotein Receptor-deficient Rabbits; The American Society for Clinicial Investigation, Inc., Jul. 1994 vol. 94, 392-398. Mao et al. Antioxidant Activity of Probucol and Its Analogues in Hypercholesterolemic watanabe Rabbits; Journal of Medicinal Chemistry Jan. 1991, vol. 34, No. 1. Mao et al. Attenuation of Atherosclerosis in a Modified Strain of Hypercholesterolemic Watanabe Rabbits with Use of a Probucol Analogue MDL29,311 That Does Not Lower serum Cholesterol; Arteriosclerosis and Thrombosis, Jul./Aug. 1991 vol. 11, No. 4. Ramasamy, Santhini et al. Modulation of Expression of Endothelial Nitric Oxide Synthase by Nordihydroguaiaretic Acid, a Phenolic Antioxidant in Cultured Endothelial Cells; Molecular Pharmacology, Apr. 5, 1999 vol. 56 116-123. Barnhart, J.W., et al., The Synthesis, Metabolism, and Biological Activity of Probucol and its Analogs, Pharmacochem. Libr. No. 17, (1991), pp. 277-299. U.S. application No. 09/078,935, Somers, filed May 14, 1998. L. Cominacini et al: Free Radical Biology and Medicine. Neuworth, Martin B, Synthesis and hypocholesterolemic activity of alkylidenedithio bisphenolis, J. Med. Chem (1970), 13(4) 722-5. De Meglio, P., New derivatives of clofibrate and probucol. Preliminary studies on hypolipemic activity. Chemical Abstracts 124:8690, 1996. Chemical Abstracts 1970:445047, 1970. Chemical Abstracts 1970:445047, 1986:28675, 1986. De Meglio, P., et al. New Derivatives of Clofibrate and Probucol. Preliminary Study of Their Hypolipemic Activity, II Farmaco--Ed. Sci. 1985, vol. 40, No. 11, pp. 833-844 (Partial Translation).