초록 ▼

A dosage form is disclosed comprising a semipermeable walled container that houses a capsule, which capsule comprises a drug formulation, a piston, and an osmotic composition. The dosage form delivers the drug formulation through a passageway at a controlled rate over a sustained-release period of t

A dosage form is disclosed comprising a semipermeable walled container that houses a capsule, which capsule comprises a drug formulation, a piston, and an osmotic composition. The dosage form delivers the drug formulation through a passageway at a controlled rate over a sustained-release period of time up to 24 hours.

대표청구항 ▼

1. A process for providing a dosage form, said process comprising the following steps: (a) blending an osmopolymer, an osmagent and a hydroxypropylalkylcellulose to provide an osmotic composition; (b) blending a hydroxyalkylcellulose with a fluid to provide a granulating fluid; (c) spraying the

1. A process for providing a dosage form, said process comprising the following steps: (a) blending an osmopolymer, an osmagent and a hydroxypropylalkylcellulose to provide an osmotic composition; (b) blending a hydroxyalkylcellulose with a fluid to provide a granulating fluid; (c) spraying the granulating fluid onto the osmotic composition; (d) blending a drug and surfactant to form a liquid drug formulation wherein the liquid drug formulation is delivered at a sustained-release rate over an extended period of time: (e) adding the liquid drug formulation into a capsule; (f) adding the osmotic composition into the capsule; (g) closing the capsule; (h) inserting the capsule into a wall housing comprised of an injection-moldable composition having a closed bottom and an open mouth; and (i) crimping the wall to close the mouth while maintaining an orifice in the dosage form. 2. The process for providing the dosage form of claim 1, wherein the housing is closed with a snap-in closure that maintains an orifice in the dosage form. 3. The process for providing the dosage form according to claim 1, wherein the liquid drug formulation is prepared as step (a). 4. The process for providing the dosage form according to claim 1, wherein step (f) is step (e). 5. A process for providing a dosage form, wherein the process comprises the following steps: (a) formulating a liquid drug formulation comprising a drug and a pharmaceutically acceptable carrier; (b) formulating an expandable composition comprising a homopolymer and an osmotically effective solute; (c) adding the therapeutic composition to a capsule; (d) adding the expandable composition to the capsule; (e) coating the capsule with an injection-moldable composition to form a wall; and (f) providing an exit means in the wall in communication with the liquid drug formulation for releasing the liquid drug formulation at a sustained-release rate over an extended period of time.