An implantable prosthesis, for example a stent, is provided having one or more micropatterned microdepots formed in the stent. Depots are formed in the prosthesis via chemical etching and laser fabrication methods, including combinations thereof. They are formed at preselected locations on the body
An implantable prosthesis, for example a stent, is provided having one or more micropatterned microdepots formed in the stent. Depots are formed in the prosthesis via chemical etching and laser fabrication methods, including combinations thereof. They are formed at preselected locations on the body of the prosthesis and have a preselected depth, size, and shape. The depots can have various shapes including a cylindrical, a conical or an inverted-conical shape. Substances such as therapeutic substances, polymeric materials, polymeric materials containing therapeutic substances, radioactive isotopes, and radiopaque materials can be deposited into the depots.
대표청구항▼
1. A method of forming depots on an implantable prosthesis comprising: providing a prosthesis having a surface applying applying a first fluid onto said surface, said first fluid forming a protective coating on said surface; generating a mask having transparent and opaque areas, said transparen
1. A method of forming depots on an implantable prosthesis comprising: providing a prosthesis having a surface applying applying a first fluid onto said surface, said first fluid forming a protective coating on said surface; generating a mask having transparent and opaque areas, said transparent areas representing said depots; illuminating said mask, wherein a light passes through said transparent areas forming exposed metal areas on said surface of said prosthesis; applying a second fluid to said prosthesis, wherein said second fluid dissolves said exposed metal areas to a predetermined depth, forming depots; removing said second fluid so that a quantity of said fluid remains within said depots, said fluid expanding the size and volume of said depots so as to provide conically shaped depots having a closed end and an open end, wherein the diameter of the open end is smaller than the diameter of the closed end; removing said quantity of said second fluid; and rinsing said prosthesis in a third fluid to remove said protective coating. 2. The method according to claim 1, wherein during said act of illuminating said mask said first fluid undergoes a photochemical reaction. 3. The method according to claim 1, wherein said first fluid forms a photoresist coating. 4. The method according to claim 1, wherein said second fluid is a ferric chloride solution. 5. The method according to claim 1, wherein said third fluid is methylene chloride. 6. The method according to claim 1, wherein said light is ultraviolet light. 7. The method according to claim 1, wherein said light is laser light. 8. The method according to claim 7, wherein said laser light is generated from an excimer laser. 9. The method according to claim 1, wherein said depots are evenly distributed throughout the body of said prosthesis and the volume of said depots is generally the same. 10. The method according to claim 1, wherein the volume of each of said depots is greater at the ends of said prosthesis as compared to the midsection of said prosthesis. 11. A method for forming depots on an implantable prosthesis, comprising: providing a prosthesis having a surface; applying a first fluid onto said surface, said first fluid forming a protective coating on said surface; selectively ablating portions of said protective coating with a laser; drilling into said prosthesis with said laser to form depots; applying a second fluid to said prosthesis, wherein said second fluid expands the size and volume of said depots to provide a conically shaped depot having an open end and a closed end, wherein the diameter of the closed end is larger than the diameter of the open end; removing said second fluid; and rinsing said prosthesis in a third fluid to remove said protective coating. 12. The method according to claim 11, wherein said laser is an UV laser. 13. The method according to claim 11, wherein said laser is an excimer laser. 14. The method according to claim 11, wherein said laser is a Nd:YAG laser. 15. The method according to claim 11, wherein the volume of each of said depots is greater at the ends of said prosthesis as compared to the midsection of said prosthesis.
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Stack Richard S. (Chapel Hill NC) Klopovic Zenaida P. (Durham NC), Absorbable stent.
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Stack Richard S. (Chapel Hill NC) Clark Howard G. (Durham NC) Walker William F. (Holcomb NY) McElhaney James H. (Durham NC), Bioabsorbable stent and method of making the same.
Eury Robert P. (Cupertino CA) Garguilo Darlene (Fremont CA) Villareal Plaridel (San Jose CA), Drug loaded polymeric material and method of manufacture.
MacGregor David C. (81 Wimbleton Rd. Islington ; Ontario CAX), Method of forming a small bore flexible vascular graft involving eluting solvent-elutable particles from a polymeric tub.
Tartaglia Joseph M. (Redwood City CA) Loeffler Joseph P. (Mountain View CA) Turnlund Todd H. (Mountain View CA), Polymer film for wrapping a stent structure.
Ragheb Anthony O. ; Bates Brian L. ; Fearnot Neal E. ; Osborne Thomas A. ; Kozma Thomas G. ; Roberts Joseph W. ; Voorhees ; III William D., Silver implantable medical device.
Hossainy, Syed F. A.; Stewart, Gordon; Williams, Mark A.; Royal, Jeff; Consigny, Paul M.; Happ, Dorrie M.; Scheinpflug, Kurt; Hu, Ty, 40-O-(2-hydroxy)ethyl-rapamycin coated stent.
Cheng, Jin; Dugan, Stephen; Stewart, Gordon; Zhang, Gina; Kirsten, Nancy; Consigny, Paul; Feezor, Christopher; Park, Gene; Roorda, Wouter; Hossainy, Syed F. A., Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device.
Boismier, Dennis A.; Girton, Timothy S.; Larsen, Steven R.; Shedlov, Matt; Merdan, Ken; O'Brien, Barry, Bioerodible endoprostheses and methods of making the same.
Pacetti, Stephen D., Biologically absorbable coatings for implantable devices based on copolymers having ester bonds and methods for fabricating the same.
Pacetti, Stephen D.; DesNoyer, Jessica R., Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same.
Pacetti,Stephen D.; DesNoyer,Jessica R., Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same.
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Hossainy, Syed F. A.; Pacetti, Stephen D.; Fong, Keith E.; Bhat, Vinayak; Sanders Millare, Deborra; Guruwaiya, Judy A.; Mirzaee, Daryush; Mandrusov, Evgenia, Coating for implantable devices and a method of forming the same.
Trollsas, Mikael O.; Ngo, Michael Huy; Maslanka, Bozena Zofia; Hossainy, Syed Faiyaz Ahmed; Kleiner, Lothar W., Coating of fast absorption or dissolution.
Pacetti,Stephen D., Coatings for drug delivery devices comprising hydrolitically stable adducts of poly(ethylene-co-vinyl alcohol) and methods for fabricating the same.
Pacetti, Stephen D.; Hossainy, Syed F. A.; Tang, Yiwen; Tung, Andrew C.; Glauser, Thierry, Coatings for drug delivery devices having gradient of hydration.
Pacetti,Stephen D.; Hossainy,Syed F. A.; Tang,Yiwen; Tung,Andrew C.; Glauser,Thierry, Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof.
Glauser, Thierry; Astafieva, Irina; Hossainy, Syed Faiyaz Ahmed, Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug.
Michal,Eugene T; Hossainy,Syed F A; Consigny,Paul M, Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine.
Dugan, Stephen Robert; DesNoyer, Jessica Reneé; Pacetti, Stephen D.; Maslanka, Bozena, Coatings for preventing balloon damage to polymer coated stents.
Hossainy, Syed F. A.; Trollsas, Mikael; Glauser, Thierry; Tang, Yiwen, Copolymer comprising elastin pentapeptide block and hydrophilic block, and medical device and method of treating.
Shanley, John F.; Litvack, Frank; Parker, Theodore L.; Nguyen, Thai Minh, Expandable medical device with openings for delivery of multiple beneficial agents.
McNiven, Andrew F.; Esbeck, Thomas D.; Ding, Ni; Pacetti, Stephen; Hossainy, Syed F. A., Fluid treatment of a polymeric coating on an implantable medical device.
De Scheerder, Ivan; Sohier, Jurgen; van der Leden, Natasja; Van Humbeeck, Jan, Intraluminar perforated radially expandable drug delivery prosthesis and a method for the production thereof.
De Scheerder, Ivan; Sohier, Jurgen; van der Leden, Natasja; Van Humbeeck, Jan, Intraluminar perforated radially expandable drug delivery prosthesis and a method for the production thereof.
De Scheerder, Ivan; Sohier, Jurgen; van der Leden, Natasja; Van Humbeeck, Jan, Intraluminar perforated radially expandable drug delivery prosthesis and a method for the production thereof.
Chandrasekaran, Chandru; Radhakrishnan, Rajesh, Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents.
Weber, Jan, Medical devices having polymeric nanoporous coatings for controlled therapeutic agent delivery and a nonpolymeric macroporous protective layer.
Hossainy, Syed F. A.; Stewart, Gordon; Williams, Mark A.; Royal, Jeff; Consigny, Paul M.; Happ, Dorie M.; Scheinpflug, Kurt; Hu, Ty, Method of coating a stent with a release polymer for 40-O-(2-hydroxy)ethyl-rapamycin.
Wu,Steven Z.; Harish,Sameer; Sanders Millare,Deborra; Guruwaiya,Judy A.; Mirzaee,Daryush; Hossainy,Syed; Chen,Charlene, Method of making an implantable medical device.
Michal, Eugene T.; Ding, Ni; Buchko, Christopher J., Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device.
Pacetti, Stephen D.; Hossainy, Syed F. A.; Tang, Yiwen; Tung, Andrew C.; Glauser, Thierry, Methods for fabricating coatings for drug delivery devices having gradient of hydration.
Pacetti, Stephen D.; Hossainy, Syed F. A.; Tang, Yiwen; Tung, Andrew C.; Glauser, Thierry, Methods for fabricating coatings for drug delivery devices having gradient of hydration.
Hossainy, Syed Faiyaz Ahmed; Tang, Yiwen; Borgaonkor, Harshad; DesNoyer, Jessica Reneé; Pacetti, Stephen D., Methods for modulating thermal and mechanical properties of coatings on implantable devices.
Wu, Steven Z.; Hossainy, Syed F. A.; Harish, Sameer; Sanders-Millare, Deborra; Mirzaee, Daryush, Methods of forming microparticle coated medical device.
Malik,Shamim M.; Claude,Charles D.; Kwok,Connie S.; Seegmiller,Michael, Plasma-generated coating apparatus for medical devices and a method of coating deposition.
Pacetti, Stephen D.; Michal, Eugene T.; Hossainy, Syed F. A.; Ding, Ni; Roorda, Wouter E., Polycationic peptide coatings and methods of coating implantable medical devices.
Pacetti, Stephen D.; Michal, Eugene T.; Hossainy, Syed F. A.; Ding, Ni; Roorda, Wouter E., Polycationic peptide coatings and methods of coating implantable medical devices.
Pacetti,Stephen D.; Michal,Eugene T; Hossainy,Syed F A; Ding,Ni; Roorda,Wouter E, Polycationic peptide coatings and methods of coating implantable medical devices.
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