IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0776471
(2001-02-02)
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발명자
/ 주소 |
- Thompson, David L.
- Mattes, Michael F.
- Larson, Lary R.
- Heruth, Kenneth T.
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출원인 / 주소 |
|
대리인 / 주소 |
Bauer, Stephen W.Waldkoetter, Eric R.Berry, Thomas G.
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인용정보 |
피인용 횟수 :
54 인용 특허 :
26 |
초록
▼
A medical device known as a therapeutic substance delivery device is configured to with an infusion rate control to deliver a therapeutic substance such as pharmaceutical compositions, genetic materials, and biologics to treat a variety of medical conditions such as pain, spastisity, cancer, and oth
A medical device known as a therapeutic substance delivery device is configured to with an infusion rate control to deliver a therapeutic substance such as pharmaceutical compositions, genetic materials, and biologics to treat a variety of medical conditions such as pain, spastisity, cancer, and other diseases in humans and other animals. The therapeutic substance delivery device can be configured as a single-use device that is versatile, small, inexpensive, and has many other improvements. The single-use device has a Micro Electro Mechanical System (MEMS) flow restriction with a variable infusion rate. The MEMS flow restriction is fluidly coupled to a reservoir outlet to receive therapeutic substance dispensed from the single-use reservoir at the reservoir rate and restrict the therapeutic substance flow to a desired infusion rate. The single-use reservoir is configured for controlled collapse to dispense therapeutic substance from the reservoir at a reservoir rate through a reservoir outlet. The therapeutic substance delivery device can also be configured as a shrink polymer delivery device that is also versatile, small, inexpensive, and has many other improvements. A flow restriction is fluidly coupled to the shrink polymer reservoir outlet to receive therapeutic substance dispensed from the reservoir at the reservoir rate and restrict the therapeutic substance flow to an infusion rate. Many embodiments of the therapeutic substance delivery device with infusion rate control and its methods of operation are possible.
대표청구항
▼
A medical device known as a therapeutic substance delivery device is configured to with an infusion rate control to deliver a therapeutic substance such as pharmaceutical compositions, genetic materials, and biologics to treat a variety of medical conditions such as pain, spastisity, cancer, and oth
A medical device known as a therapeutic substance delivery device is configured to with an infusion rate control to deliver a therapeutic substance such as pharmaceutical compositions, genetic materials, and biologics to treat a variety of medical conditions such as pain, spastisity, cancer, and other diseases in humans and other animals. The therapeutic substance delivery device can be configured as a single-use device that is versatile, small, inexpensive, and has many other improvements. The single-use device has a Micro Electro Mechanical System (MEMS) flow restriction with a variable infusion rate. The MEMS flow restriction is fluidly coupled to a reservoir outlet to receive therapeutic substance dispensed from the single-use reservoir at the reservoir rate and restrict the therapeutic substance flow to a desired infusion rate. The single-use reservoir is configured for controlled collapse to dispense therapeutic substance from the reservoir at a reservoir rate through a reservoir outlet. The therapeutic substance delivery device can also be configured as a shrink polymer delivery device that is also versatile, small, inexpensive, and has many other improvements. A flow restriction is fluidly coupled to the shrink polymer reservoir outlet to receive therapeutic substance dispensed from the reservoir at the reservoir rate and restrict the therapeutic substance flow to an infusion rate. Many embodiments of the therapeutic substance delivery device with infusion rate control and its methods of operation are possible. adapted to provide an electrical current through at least a portion of said thoracic cavity via at least a first of said plurality of electrodes, and produce an impedance waveform relating thereto on at least a second of said plurality of electrodes; and a signal processing apparatus, operatively coupled to said at least second of said plurality of electrodes, said signal processing apparatus adapted to analyze said impedance waveform using wavelet transforms to assess said at least one hemodynamic parameter. 25. The apparatus of claim 24, wherein said at least one hemodynamic parameter comprises stroke volume, and at least one of said plurality of electrodes comprises a spot electrode having a plurality of electrically conductive terminals disposed thereon. 26. The apparatus of claim 25, wherein said spot electrode comprises two terminals, and said two terminals are spaced at a predetermined distance from each other. 27. The apparatus of claim 24, wherein said signal processing apparatus is further adapted to measure at least one electrocardiographic (ECG) waveform via at least one of said plurality of electrodes, and analyze said ECG waveform using wavelet transforms. 28. The apparatus of claim 24, wherein said signal processing apparatus comprises: signal conditioning apparatus adapted to condition at least said impedance waveform; an analog-to-digital converter to convert at least a portion of said impedance waveform to binary digital format data; and a digital processor adapted to run at least one computer program thereon, said at least one computer program being configured to calculate at least one wavelet transform based on said binary digital format data. 29. The apparatus of claim 28, wherein said digital processor comprises a digital signal processor (DSP), and at least a portion of said computer is disposed within an embedded memory associated therewith. 30. The apparatus of claim 27, wherein said signal processing apparatus is adapted to identify at least one QRS complex using said wavelet transforms. 31. The apparatus of claim 27, wherein said signal processing apparatus is adapted to identify at least one Q point within said ECG waveform, said analysis of said impedance waveform using wavelet
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