초록 ▼

A method is provided for increasing the permeability of skin or mucosal tissue to transdermally administered steroid drugs. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the drug through a body surface while minimizing the

A method is provided for increasing the permeability of skin or mucosal tissue to transdermally administered steroid drugs. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the drug through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Formulations and drug delivery systems for co-administering a hydroxide-releasing agent with a steroid drug are provided as well. Optimally, the steroid drugs are a combination of an estrogen and progestin that may be administered in female hormone replacement therapy, to provide female contraception, and the like.

대표청구항 ▼

A method is provided for increasing the permeability of skin or mucosal tissue to transdermally administered steroid drugs. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the drug through a body surface while minimizing the

A method is provided for increasing the permeability of skin or mucosal tissue to transdermally administered steroid drugs. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the drug through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Formulations and drug delivery systems for co-administering a hydroxide-releasing agent with a steroid drug are provided as well. Optimally, the steroid drugs are a combination of an estrogen and progestin that may be administered in female hormone replacement therapy, to provide female contraception, and the like. , preservatives, UV absorbers, anti-oxidants, coloring agents, skin-improvers, humectants, perfumes or vehicle components for a mousse, tonic, spray or gel, wherein said carriers, solvents, preservatives, UV absorbers, anti-oxidants, coloring agents, skin-improvers, humectants, perfumes or vehicle components for a mousse, tonic, spray or gel are chosen so as not to damage or negatively affect the aesthetics of hair or cause irritation to skin. 6. A method for treating hair, which comprises preparing the mouse, tonic, spray or gel of claim 5 and applying said mouse, tonic, spray or gel to the surface of hair. 7. A hair cosmetic composition comprising a graft or block copolymer in an amount of 0.01 to 30% by weight of the composition of the formula wherein G5represents monovalent moieties which can independently be the same or different selected from the group consisting of alkyl, aryl, alkaryl, alkoxy, alkylamino, fluoroalkyl, hydrogen, and --ZSA; A represents a vinyl copolymeric segment consisting essentially of copolymerized free radically copolymerizable monomer, Z is a divalent linking group; G6represents monovalent moieties which can independently be the same or different selected from the group consisting of alkyl, aryl, alkaryl, alkoxy, alkylamino, fluoroalkyl, hydrogen, and --ZSA; G2comprises A; G4comprises A; R1represents monovalent moieties which can independently be the same or different and are selected from the group consisting of alkyl, aryl, alkaryl, alkoxy, alkylamino, fluoroalkyl, hydrogen, and hydroxyl; R2can independently be the same or different and represents divalent linking groups; R3represents monovalent moieties which can independently be the same or different and are selected from the group consisting of alkyl, aryl, alkaryl, alkoxy, alkylamino, fluoroalkyl, hydrogen, and hydroxyl; R4can independently be the same or different and are divalent linking groups; x is an integer of 0-3; y is an integer of 5 or greater; q is an integer of 0-3; wherein at least one of the following is true: q is an integer of at least 1; x is an integer of at least 1; G5comprises at least one --ZSA moiety; and G6comprises at least one --ZSA moiety, wherein said hair cosmetic composition is a rinse or hair treatment, the balance of said composition comprising one or more compounds chosen from the group of carriers, solvents, preservatives, UV absorbers, anti-oxidants, coloring agents, skin-improvers, humectants, perfumes or vehicle components for a rinse or hair treatment, wherein said carriers, solvents, preservatives, UV absorbers, anti-oxidants, coloring agents, skin-improvers, humectants, perfumes or vehicle components for a rinse or hair treatment are chosen so as not to damage or negatively affect the aesthetics of hair or cause irritation to skin. 8. A method for treating hair, which comprises preparing the ri