Solid carriers for improved delivery of hydrophobic active ingredients in pharmaceutical compositions
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/16
A61K-009/28
A61K-009/32
A61K-009/52
A61K-009/56
A61K-009/58
출원번호
US-0800593
(2001-03-06)
발명자
/ 주소
Patel, Mahesh V.
Chen, Feng-Jing
출원인 / 주소
Lipocine, Inc.
대리인 / 주소
Reed, Dianne E.Reed & Eberle LLP
인용정보
피인용 횟수 :
378인용 특허 :
15
초록▼
The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier including a
The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier including a substrate and an encapsulation coat on the substrate. The encapsulation coat can include different combinations of pharmaceutical active ingredients, hydrophilic surfactant, lipophilic surfactants and triglycerides. In another embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier being formed of different combinations of pharmaceutical active ingredients, hydrophilic surfactants, lipophilic surfactants and triglycerides. The compositions of the present invention can be used for improved delivery of hydrophilic or hydrophobic pharmaceutical active ingredients, such as drugs, nutrionals, cosmeceuticals and diagnostic agents.
대표청구항▼
The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier including a
The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier including a substrate and an encapsulation coat on the substrate. The encapsulation coat can include different combinations of pharmaceutical active ingredients, hydrophilic surfactant, lipophilic surfactants and triglycerides. In another embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier being formed of different combinations of pharmaceutical active ingredients, hydrophilic surfactants, lipophilic surfactants and triglycerides. The compositions of the present invention can be used for improved delivery of hydrophilic or hydrophobic pharmaceutical active ingredients, such as drugs, nutrionals, cosmeceuticals and diagnostic agents. ressing said first feedstock to form a first green part; placing said first green part into a second mold; thereafter injecting said second feedstock into said second mold; thereafter pressing said second feedstock to form said first and second green parts wherein said first and second green parts comprise a combined green part; removing said lubricants and said binders from said first and second green parts to form a powdered skeleton; and sintering said powdered skeleton to complete said combined enclosure and heat sink structure. 25. The method according to claim 24 wherein said first mixture of powdered materials comprises one or more materials selected from the group consisting of: nickel, cobalt, iron, molybdenum, stainless steel, tungsten, tungsten-copper, molybdenum, molybdenum-copper, aluminum, aluminum nitride, alumina, and Kovar. 26. The method according to claim 24 wherein said second mixture of powdered materials comprises one or more materials selected from the group consisting of: alumin
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이 특허에 인용된 특허 (15)
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