[미국특허]
Methods and compositions for polypeptide engineering
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C12Q-001/68
C12P-019/34
A61K-038/00
C07K-014/00
C07H-021/04
출원번호
US-0693350
(2000-10-20)
발명자
/ 주소
Patten, Phillip A.
Stemmer, Willem P. C.
출원인 / 주소
Maxygen, Inc.
대리인 / 주소
Kruse, Norman J.Sappenfield, Christopher C.Quine I.P. Group
인용정보
피인용 횟수 :
32인용 특허 :
118
초록
Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.
대표청구항▼
Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed. (1988). Grinell and Wagner, J. Virology 48:88-101 (1983). Gunnery et al., "Tat-Resp
Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed. (1988). Grinell and Wagner, J. Virology 48:88-101 (1983). Gunnery et al., "Tat-Respponsive Region RNA of Human Immunodeficiency Virus 1 Can Prevent Activation of the Double-Stranded-RNA-Activated Protein Kinase," Proc. Natl. Acad. Sci. USA 87:8687-8691 (1990). Gura, Science, vol. 270, pp. 575-577, Oct. 27, 1995. Gutierrez et al., "Transient Inhibition of Foot-and-Mouth Disease Virus Infection of BHK-21 cells by Antisense Oligonucleotides Directed Against the Second Functional Initiator AUG," Antiviral Research 22:1-13 (1993). Halbert et al., J. Virology 86:250-257 (1985). Hambidge SJ, and Sarnow P. "Terminal 7-methyl-guanosine cap structure on the normally uncapped 5'noncoding region of poliovirus mRNA inhibits its translation in mammalian cells." J Virol. 1991 Nov;65(11):6312-5. Han et al., Proc. Natl. Acad. Sci. USA 88:1711-1715 (1991). Hanecak, R. et al., J. Virol. 70(8):5203-12 (Aug 1996). Herman, "Alternatives for the Initiation of Translation, " TIBS 14:219-222 (1989). Hershey, "Translational Control in Mammalian Cells," Ann. Rev. Biochem. 60:717-755 (1991). Hershey, "Introduction to Translational Initiation Factors and Their Reulation by Phosphorylation," Seminars in Virology 4:201-207 (1993). Huang and Schneider, Cell 65:271-280 (1991). Hughes et al., J. Gen. Virol. 69:49-58 (1988). Hughes et al., J. Gen. Virol. 67:2093-2102 (1986). Hughes et al., J. Gen. Virol. 70:2943-2952 (1989). Iizuka et al., Virology 156:64. Imani and Jacobs, Proc. Natl. Acad. Sci. USA 85:7887-7891 (1988). Inchauspe et al., Proc. Natl. Acad. Sci. USA 88:10293 (1991). Inglis, Mol. Cell. Biol. 2:1644-1648 (1982). Jacks et al., "Characterization of Ribosomal Frameshifting in HIV -1 gag-pol expression," Nature 331-280 (1988). Jackson, "Initation Without an End," Nature 353:14-15 (1991). Jackson et al., "The Novel Mechanism of Initiation of Picornavirus RNA Translation," Trends Biochem. Sci. 15:477-482 (1990). Jang et al., Enzyme 44:292-309 (1990). Jang and Wimmer, Genes Dev. 4:1560-1572 (1990). Jang et al., J. Virol. 63:1651 (1989). Jang SK, et al., "A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation," J. Virol 1988 Aug:62(8):2636-43. Jean-Jean et al., J. Virology 63:5451-5454 (1989). Jenkins, J. Gen. Virol 68:1835-1848 (1987). Kato et al., Proc. Natl. Acad. Sci. USA 87:9524-9528 (1990). Katze, J. Interferon Res. 12:241-248 (1992). Katze, "Games Viruses Play: a Stretegic Intiative Against the Interfero-Induced dsRNA Activisted 68,000 MrProtein Kinase," Seminars in Virology 4:259-268 (1993). Katze et al., J. Virology 62:3710-3717 (1988). Kozak, "The Scanning Model for Translation: An Update," J. Cell. Biol. 108:229-241 (1989). Kozak, "A Consideration of Alternative Models for the Intitiation of Tranlsation in Eukaryotes," Crit. Rev. Biochem. Mol. Biol. 27:385-402 (1992). Kuhn et al., J. Virol. 64:4625 (1990). Kwong et al., J. Virology 62:912-921 (1988). La Monica et al., J. Virology 57:515 (1986). Le and Zuker, J. Mol. Biol. 216-729-741 (1990). Lee et al., Proc. Natl. Acad. Sci. USA 87:6208-6212 (1990). Lima et al., J. Biol. Chem. 272(1):626-638 (1997)Lima et al., J. Biol. Chem. 272(1):626-638 (1997). Lindberg et al., Virology 156:50 (1987). Linemeyer et al., J. Virol. 54:252 (1985). Luz and Beck, J. Virol 65:6486-6494 (1991). Ma and Mathews, "Comparative Analysis of the Structure and Function of Adenovirus Asociated RNAs," J. Virol. 67:6605-6617 (1993). Macejak and Sarnow. "Internal Initiation of Translation Mediated by the 5' Leader of a Cellular mRNA," 353-90-94 (1991). Mathews, "Viral Evasion of Cellular Defense Mechanism: Regulation of the Protein Kinase DAI by RNA Effectors," Seminars in Virology 4:247-257 (1993). Mathews and Shenk, "Adenovirus Virus-Associated RNA and Translation Control," J. Virology 65:5657-5662 (1991). Meerovitch and Soneberg, Seminars Virol. 4:217 (1993). Meerovitch et al., J.
Goodman Thomas C. (Mountain View CA) Becker Martin (Palo Alto CA) Ullman Edwin F. (Atherton CA) Rose Samuel (Mountain View CA), Amplification method for polynucleotide assays.
Birkenmeyer Larry G. (Chicago IL) Carrino John J. (Gurnee IL) Dille Bruce J. (Antioch IL) Hu Hsiang-Yun (Libertyville IL) Kratochvil Jon D. (Kenosha WI) Laffler Thomas G. (Libertyville IL) Marshall R, Amplification of target nucleic acids using gap filling ligase chain reaction.
Waldmann Herman (University of Cambridge ; Department of Pathology ; Immunology Div. ; Tennis Court Road Cambridge ; CB2 1QP GB3) Walsh Louise (The University of Cambridge ; Department of Pathology ;, CDR grafted humanised chimeric T-cell antibodies.
Goodman Myron F. (4719 Alminar Ave. LaCanada CA 91011) Reha-Krantz Linda J. (10044 87th Avenue Edmonton ; Alberta CAX T6E 2N9 ), Chain-terminating nucleotides for DNA sequencing methods.
Maliga Pal ; Maliga Zora Svab ; Staub Jeffrey M. ; Zoubenko Oleg ; Allison Lori A. ; Carrer Helaine,BRX ; Kanevski Ivan, DNA constructs and methods for stably transforming plastids of multicellular plants and expressing recombinant proteins.
Sninsky John J. (El Sobrante CA) Kwok Shirley Y. (San Ramon CA) Mack David H. (Berkeley CA) Ehrlich Henry A. (Oakland CA) Mullis Kary B. (LaJolla CA), Detection of viruses by amplification and hybridization.
Ladner Robert Charles ; Gutterman Sonia Kosow ; Roberts Bruce Lindsay ; Markland William ; Ley Arthur Charles ; Kent Rachel Baribault, Directed evolution of novel binding proteins.
Garrard Lisa J. ; Henner Dennis J. ; Bass Steven ; Greene Ronald ; Lowman Henry B. ; Wells James A. ; Matthews David J., Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants.
Kucherlapati Raju (Darien CT) Koller Beverly H. (Carrboro NC) Smithies Oliver (Chapel Hill NC) Dubridge Robert B. (Belmont CA) Greenburg Gary (San Carlos CA) Capon Daniel J. (Hillsborough CA) William, Homologous recombination for universal donor cells and chimeric mammalian hosts.
Weiss Samuel,CAX ; Reynolds Brent,CAX ; Hammang Joseph P. ; Baetge E. Edward, In vivo genetic modification of growth factor-responsive neural precursor cells.
Braford-Goldberg Sarah R. (St. Louis MO) Easton Alan M. (Maryland Heights MO) Klein Barbara K. (St. Louis MO) McKearn John P. (Pacific MO) Olins Peter O. (Glencoe MO), Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same.
Backman Keith C. ; Bond Sheila B. ; Carrino John J. ; Laffler Thomas G., Method and kits for amplifying target nucleic acids applicable to both polymerase and ligase chain reactions.
Goeddel David V. (Hillsborough CA) Rice Glenn C. (Palo Alto CA) Leung David W. H. (Foster City CA), Method for making variant secreted proteins with altered properties.
Dubensky ; Jr. Thomas W. ; Polo John M. ; Chang Steven M.W. ; Jolly Douglas J., Method for stimulating an immune response utilizing recombinant alphavirus particles.
Khosla Chaitan (Stanford CA) Caren Robert (Stanford CA), Method of generating multiple protein variants and populations of protein variants prepared thereby.
Kauffman Stuart Alan ; Ballivet Marc,CHX, Method of identifying a stochastically-generated peptide, polypeptide, or protein having ligand binding property and co.
Thompson Katie A. ; Foster Lyndon M. ; Peterson Todd C. ; Nasby Nicole Marie ; Brian Paul, Methods for generating and screening novel metabolic pathways.
Stemmer Willem P. C. ; Crameri Andreas, Methods for generating polynucleotides having desired characteristics by iterative selection and recombination.
Stemmer Willem P. C. ; Crameri Andreas, Methods for generating polynucleotides having desired characteristics by iterative selection and recombination.
Wallach David (Rehovot ILX) Brakebusch Cord (Braunschweig DEX) Varfolomeev Eugene (Rehovot ILX) Batkin Michael (Rehovot ILX), Molecules influencing the shedding of the TNF receptor, their preparation and their use.
Dahlberg James E. (Madison WI) Lyamichev Victor I. (Madison WI) Brow Mary Ann D. (Madison WI), Nucleic acid encoding synthesis-deficient thermostable DNA polymerase.
Nitecki Danute E. (Berkeley CA) Katre Nandini (El Cerrito CA) Goodson Robert J. (Albany CA) Aldwin Lois (San Mateo CA), Preparation of a polymer/interleukin-2 conjugate.
Mullis Kary B. (La Jolla CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or cloning nucleic acid sequences.
Mullis Kary B. (La Jolla CA) Erlich Henry A. (Oakland CA) Gelfand David H. (Oakland CA) Horn Glenn (Emeryville CA) Saiki Randall K. (Richmond CA), Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme.
Honjo Tasuku (Kanyu-chi ; Oiwake-cho ; Kita-Shirakawa Sakyo-ku ; Kyoto ; Kyoto JPX) Tashiro Kei (Kyoto JPX) Tada Hideaki (Mishima JPX), Process for constructing cDNA library, and novel polypeptide and DNA coding for the same.
Kauffman Stuart Alan ; Ballivet Marc,CHX, Process for the production of expression vectors comprising at least one stochastic sequence of polynucleotides.
Kauffman Stuart Alan ; Ballivet Marc,CHX, Process for the production of stochastically-generated peptides,polypeptides or proteins having a predetermined propert.
Hoogenboom Hendricus R. J. M. (Cambridge GBX) Baier Michael (Frankfurt DEX) Jespers Laurent S. A. T. (Tervuren BEX) Winter Gregory P. (Cambridge GBX), Production of chimeric antibodies - a combinatorial approach.
Cabilly Shmuel (Monrovia CA) Heyneker Herbert L. (Burlingame CA) Holmes William E. (Pacifica CA) Riggs Arthur D. (La Verne CA) Wetzel Ronald B. (San Francisco CA), Recombinant immunoglobin preparations.
Arnold Frances H. ; Shao Zhixin ; Affholter Joseph A. ; Zhao Huimin ; Giver Lorraine J., Recombination of polynucleotide sequences using random or defined primers.
Arnold Frances H. ; Shao Zhixin ; Affholter Joseph A. ; Zhao Huimin H ; Giver Lorraine J., Recombination of polynucleotide sequences using random or defined primers.
Gelfand David H. (Oakland CA) Kwok Shirley Y. (San Ramon CA) Sninsky John J. (El Sobrante CA), Reduction of non-specific amplification glycosylase using DUTP and DNA uracil.
Varadaraj Ramesh (Flemington NJ) Brons Cornelius H. (Washington NJ) Bock Jan (Warren NJ) Brois Stanley J. (Westfield NJ), Surfactant-nutrients for bioremediation of hydrocarbon contaminated soils and water.
Agard, Nicholas J.; Alvizo, Oscar; Mayo, Melissa Ann; Minor, Stefanie Ng; Riggins, James Nicholas; Moore, Jeffrey C., Engineered imine reductases and methods for the reductive amination of ketone and amine compounds.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.