초록 ▼

A trephine can separate a cornea into at least two portions by applanating and cutting a boundary around an area of the cornea. The trephine comprises a flat ring for applanating the cornea and a blade for cutting the applanated cornea. The blade extends radially inward and is rotatable around the r

A trephine can separate a cornea into at least two portions by applanating and cutting a boundary around an area of the cornea. The trephine comprises a flat ring for applanating the cornea and a blade for cutting the applanated cornea. The blade extends radially inward and is rotatable around the ring. Such a trephine can cut substantially parallel to the flattened lamella and causes lamellar separation at the cut depth. A flap of cornea may be separated from the remaining corneal tissue along the lamella by teasing the portions apart, or by injecting fluid between the lamellae. An exposed surface of the separated cornea may then be ablated with a laser and the flap reattached to the remaining corneal tissue.

대표청구항 ▼

A trephine can separate a cornea into at least two portions by applanating and cutting a boundary around an area of the cornea. The trephine comprises a flat ring for applanating the cornea and a blade for cutting the applanated cornea. The blade extends radially inward and is rotatable around the r

A trephine can separate a cornea into at least two portions by applanating and cutting a boundary around an area of the cornea. The trephine comprises a flat ring for applanating the cornea and a blade for cutting the applanated cornea. The blade extends radially inward and is rotatable around the ring. Such a trephine can cut substantially parallel to the flattened lamella and causes lamellar separation at the cut depth. A flap of cornea may be separated from the remaining corneal tissue along the lamella by teasing the portions apart, or by injecting fluid between the lamellae. An exposed surface of the separated cornea may then be ablated with a laser and the flap reattached to the remaining corneal tissue. 20001200, Guziak et al.; US-6178354, 20010100, Gibson; US-6325796, 20011200, Berube et al., 606/033 Angioplasty in the Hypercholesterolemic Rabbit Model," Circulation, vol. 89, No. 6, pp 2809-2815, Jun. 1994. -Christina Unterberg, M.D. et al., "Reduced Acute Thrombus Formation Results in Decreased Neointimal Proliferation After Coronary Angioplasty", JACC, vol. 26, No. 7, pp 1747-1754, Dec. 1995. Lewis W. Johnson et al., "Review of Radiation Safety in the Cardiac Catheterization Laboratory", Catheterization and Cardiovascular Diagnosis, vol. 25, pp 186-194, 1992. -Robert S. Schwartz et al., "Differential Neointimal Response to Coronary Artery Injury in Pigs and Dogs", Arteriosclerosis and Thrombosis, vol. 14, No. 3, pp 395-400, Mar. 1994. -Michael Haude, M.D. et al, "Quantitative Analysis of Elastic Recoil after Ballon Angioplasty and After Intracoronary Implantation of Ballon-Expandable Palmaz-Schatz Stents", JACC, vol. 21, No. 1, pp 26-34, Jan. 1993. William S. Weintraub M.D. et al., "Can Restenosis After Coronary Angioplasty Be Predicted From Clinical Variables?", JACC, vol. 21, No. 1, pp 6-14, Jan. 1993. -Richard V. Calfee, Ph.D., "High Dose Rate Afterloader System For Endovascular Use-Neocardia", Discoveries in Radiation for Restenosis, Abstract 39, pp 119, Jan. 1996. -Dr. Edward F. Smith III, "Issues on Handling Radioactive Devices to Prevent Restenosis", , Discoveries in Radiation for Restenosis, Abstract 40, pp 121-122, Jan. 1996. -Richard E. Kunts, M.D. et al., "Generalized Model of Restenosis After Conventional Ballon Angioplasty, Stenting and Directional Atherectomy", JACC, vol. 21. No. 1, pp 15-25, Jan. 1993. -Eric Van't Hooft, et al., "HDR Afterloader for Vascular Use", Discoveries in Radiation for Restenosis, Abstract 36, p 113, Jan. 1996. -Robert E. Fischell, et al., "The Radioisotope Stent: Conception and Implementation", Discoveries in Radiation for Restenosis, Abstract 37, p 115, Jan. 1996. -Youri Popowski M.D., et al., "Radioactive Wire in a Self-Centering Catheter System", Discoveries in Radiation for Restenosis, Abstract 38, pp 117-118, Jan. 1996. -Philip Urban, M.D. et al., "Endovascular Irradiation with 90Y Wire", Discoveries in Radiation for Restenosis, Abstract 33, pp 103-104, Jan. 1996. -Jose A. Condado, et al., "Late Follow-up After Percutaneous Transluminal Coronary Angioplasty (PTCA) and Intracoronary Radiation Therapy (ICRT)," Discoveries in Radiation for Restenosis, Abstract 34, p 105, Jan. 1996. -Thomas D. Weldon, "Catheter Based Beta Radiation System", Discoveries in Radiation for Restenosis, Abstract 35, p 111, Jan. 1996. -Ron Waksman, M.D., "Radiation in the Peripheral System at Emory," Discoveries in Radiation for Restenosis, Abstract 30, pp 93-94, Jan. 1996. -Paul S. Teirstein et al., "Catheter-Based Radiation Therapy to Inhibit Restenosis Following Coronary Stenting," Discoveries in Radiation for Restenosis, Abstract 31, p 99, jan. 1996. -Spencer B. King III, M.D., "Clinical Restenosis Trails Using Beta Energy Radiation," Discoveries in Radiation for Restenosis, Abstract 32, pp 101-102, Jan. 1996. -Louis G. Martin, M.D., "Radiation for Peripheral Application: Technical Aspects, " Discoveries in Radiation for Restenosis, Abstract 27, pp 81-81, Jan. 1996. -Alan B. Lumsden, M.D. et al, "Restenosis in Peripheral Vascular Disease," Discoveries in Radiation for Restenosis, Abstract 28, pp 83-88, Jan. 1996. -B. Schopohl et al., "Endovascular Irradiation for Avoidance or Recurrent Stenosis After Stent Implantation in Peripheral Arteries-5 years Follow-up", Discoveries in Radiation for Restenosis, Abstract 29, pp 89-92, Jan. 1996. -Joseph G. Wiedermann, M.D. et al., "Intracoronary Irradiation Markedly Reduces Restenosis After Balloon Angioplasty in a Porcine Model", JACC, vol. 23, No. 6, pp 1491-1498, May 1994. -Tim A. Fischell, M.D. et al., "Low-Dose B-Particle Emission from `Stent` Wire Results in Complete, Localized Inhibition of Smooth Muscle Cell Proliferation", Circulation, vol. 90, No. 6, pp 2956-2963, Dec. 1994. Maria G. M. Hunink, M.D et al., "Risks and Benefits of