Spray drying of macromolecules to produce inhaleable dry powders
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/14
A61K-009/12
출원번호
US-0423515
(1995-04-14)
발명자
/ 주소
Platz, Robert M.
Patton, John S.
Foster, Linda
Eljamal, Mohammed
출원인 / 주소
Inhale Therapeutic Systems, Inc.
대리인 / 주소
Evans, Susan T.Cagan, Felissa H.Hurst, Stephen L.
인용정보
피인용 횟수 :
172인용 특허 :
110
초록▼
According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a moisture content of less than about 10% by w
According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a moisture content of less than about 10% by weight (%w) water, usually below about 5%w and preferably less than about 3%w; a particle size of about 1.0-5.0 μm mass median diameter (MMD), usually 1.0-4.0 μm MMD, and preferably 1.0-3.0 μm MMD; a delivered dose of about >30%, usually >40%, preferably >50%, and most preferred >60%; and an aerosol particle size distribution of about 1.0-5.0 μm mass median aerodynamic diameter (MMAD), usually 1.5-4.5 μm MMAD, and preferably 1.5-4.0 MMAD. Such composition are of pharmaceutical grade purity.
대표청구항▼
According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a moisture content of less than about 10% by w
According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a moisture content of less than about 10% by weight (%w) water, usually below about 5%w and preferably less than about 3%w; a particle size of about 1.0-5.0 μm mass median diameter (MMD), usually 1.0-4.0 μm MMD, and preferably 1.0-3.0 μm MMD; a delivered dose of about >30%, usually >40%, preferably >50%, and most preferred >60%; and an aerosol particle size distribution of about 1.0-5.0 μm mass median aerodynamic diameter (MMAD), usually 1.5-4.5 μm MMAD, and preferably 1.5-4.0 MMAD. Such composition are of pharmaceutical grade purity. h; about 3% w/w ascorbyl palmitate; about 2% w/w tocopherol (natural); and water. 12. A dietary supplement comprising beadlets, vitamins and minerals, wherein the beadlets comprise one or more xanthophyll(s), one or more carotene(s)/retinoid(s), one or more antioxidant(s) and one or more solidifying agent(s). 13. A dietary supplement according to claim 12, wherein the xanthophyll(s) are selected from the group consisting of lutein, zeaxanthin, astaxanthin, canthaxanthin and cryptoxanthin. 14. A dietary supplement according to claim 12, wherein the carotene(s)/retinoid(s) is/are selected from the group consisting of alpha-, beta-, gamma-, delta-, epsilon- and psi-carotene, Vitamin A and Vitamin A analogs. 15. A dietary supplement according to claim 12, wherein the antioxidant(s) is/are selected from the group consisting of: tocotrienols, alpha-, beta-, gamma-, delta- and epsilon- tocopherol, and their corresponding acetates and succinates; Vitamin C, ascorbyl palimate and related derivatives; oil of rosemary and natural antioxidant oils. 16. A dietary supplement according to claim 12, wherein the xanthophyll(s) are lutein and zeaxanthin and the carotene(s)/retinoid(s) is beta-carotene. 17. A dietary supplement according to claim 16, wherein the beadlets comprise: about 3% w/w beta carotene; about 3% w/w lutein/zeaxanthin; about 30% w/w hydrolyzed gelatin; about 23% w/w vegetable Oil/Oleoresin; about 15% w/w sucrose; about 17% w/w food grade corn starch; about 3% w/w ascorbyl palmitate; about 2% w/w tocopherol (natural); and water. 18. A dietary supplement according to claim 16, wherein the ratio of lutein:zeaxanthin is in a range between 1:0.05 and 0.05:1. 19. A dietary supplement according to claim 13, wherein the beadlets comprise: about 3% w/w beta carotene; about 1% w/w lutein; about 1% w/w zeaxanthin; about 1% w/w astaxanthin; about 30% w/w hydrolyzed gelatin; about 23% w/w vegetable Oil/Oleoresin; about 15% w/w sucrose; about 17% w/w food grade corn starch; about 3% w/w ascorbyl palmitate; about 2% w/w tocopherol (natural); and water. 20. A dietary supplement according to claim 12, wherein the beadlets further comprise one or more bioflavonoid(s). 21. A dietary supplement according to claim 20, wherein the bioflavonoid(s) is/are selected from the group consisting of: quercetin, acacetin, liquritin, rutin, taxifulin, nobiletin, tangeretin, apigenin, chyrsin, kaempferol and derivatives thereof. 22. A dietary supplement according to claim 21, wherein the beadlets comprise: about 2% w/w beta carotene; about 1% w/w lutein; about 1% w/w zeaxanthin; about 1% w/w astaxanthin; about 1% w/w quercetin; about 30% w/w hydrolyzed gelatin; about 23% w/w vegetable Oil/Oleoresin; about 15% w/w sucrose; about 17% w/w food grade corn starch; about 3% w/w ascorbyl palmitate; about 2% w/w tocopherol (natural); and water. 23. A dietary supplement according to claim 12, comprising: about 85 mg of the beadlets; about 7 mg of Vitamin B-2; about 200 mg of Vitamin C; about 75 IU of Vitamin E; about 2 mg of copper; about 5 mg of manganese; about 20 mcg of selenium; and about 30 mg of zinc (acetate). 24. A dietary supplement according to claim 17, comprising: about 85 mg of the beadlets; about 7 mg of Vitamin B-2; about 200 mg of Vitamin C; about 75 IU of Vitamin E; about 2 mg of copper; about 5 mg of manganese; about 20 mcg of selenium; and about 30 mg of zinc (acetate). 25. A method of supplementing the dietary health of a mammal or treating the mammal for diseases or disorders which comprises administering to the mammal a dietary supplement comprising beadlets, vitamins and minerals, wherein the beadlets comprise one or more xanthophyll(s), one or more carotene(s)/retinoid(s), one or more antioxidant(s) and one or more solidifying agent(s). 26. A method according to claim 25, wherein the supplement is administered to the mammal to supplement the mammal's ocular health or to t
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