Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/02
A61L-015/16
출원번호
US-0931319
(2001-08-16)
발명자
/ 주소
Moro, Daniel G.
Callahan, Howard
Nowotnik, David
출원인 / 주소
Access Pharmaceuticals, Inc.
대리인 / 주소
Jackson Walker, LLP
인용정보
피인용 횟수 :
105인용 특허 :
60
초록▼
The present invention relates to a layered pharmaceutical delivery device for the administration of pharmaceuticals or other active compounds to mucosal surfaces. The device may also be used by itself without the incorporation of a therapeutic. The device of the present invention consists of a water
The present invention relates to a layered pharmaceutical delivery device for the administration of pharmaceuticals or other active compounds to mucosal surfaces. The device may also be used by itself without the incorporation of a therapeutic. The device of the present invention consists of a water-soluble adhesive layer, a non-adhesive, bioerodable backing layer and one or more pharmaceuticals if desired in either or both layers. Upon application, the device adheres to the mucosal surface, providing protection to the treatment site and localized drug delivery. The "Residence Time", the length of time the device remains on the mucosal surface before complete erosion, can be easily regulated by modifications of the backing layer.
대표청구항▼
The present invention relates to a layered pharmaceutical delivery device for the administration of pharmaceuticals or other active compounds to mucosal surfaces. The device may also be used by itself without the incorporation of a therapeutic. The device of the present invention consists of a water
The present invention relates to a layered pharmaceutical delivery device for the administration of pharmaceuticals or other active compounds to mucosal surfaces. The device may also be used by itself without the incorporation of a therapeutic. The device of the present invention consists of a water-soluble adhesive layer, a non-adhesive, bioerodable backing layer and one or more pharmaceuticals if desired in either or both layers. Upon application, the device adheres to the mucosal surface, providing protection to the treatment site and localized drug delivery. The "Residence Time", the length of time the device remains on the mucosal surface before complete erosion, can be easily regulated by modifications of the backing layer. rate a secure interfacial bond directly between said host bone and said prosthesis. 4. A method for providing tissue-engineering scaffolds for bone replacement in human or animal hosts using a biomaterial compound comprising calcium, oxygen and phosphorous, wherein a portion of at least one of said elements is substituted with an element having an ionic radius of approximately 0.1 to 0.6 .ANG.; said method comprising the steps of: forming said biomaterial compound as a macroporous structure comprising an open cell construction with interconnected voids, combining mature and/or precursor bone cells with said macroporous structure, and allowing the cells to infiltrate said structure in order to develop new mineralized matrix throughout said structure. 5. A method for delivering pharmaceutical agents to the site of skeletal surgery in human or animal hosts using a biomaterial compound comprising calcium, oxygen and phosphorous, wherein a portion of at least one of said elements is substituted with an element having an ionic radius of approximately 0.1 to 0.6 .ANG.; said method comprising the steps of: combining a pharmaceutical agent with said biomaterial compound and applying the pharmaceutical agent combined with said biomaterial compound to a site of skeletal surgery, wherein such application results in controlled local release of said pharmaceutical agent. 6. The method of claim 5, wherein said biomaterial compound has the formula (Ca)i[(P1-x-y-zBxCyDz)Oj]2 wherein: B, C and D are selected from those elements having an ionic radius of approximately 0.1 to 0.4.ANG.; x is greater than or equal to zero but less than 1; y is greater than or equal to zero but less than 1; z is greater than or equal to zero but less than 1; x+y+z is greater than zero but less than 1; i is greater than or equal to 2 but less than or equal to 4; and j equals 4-δ, where δ is greater than or equal to zero but less than or equal to 1. 7. The method of claim 6, wherein said biomaterial compound is provided as a composition additionally comprising at least one calcium phosphate material selected from the group consisting of calcium hydroxyapatite, α-TCP, β-TCP, octacalcium phosphate, tetracalcium phosphate, dicalcium phosphate and calcium oxide. 8. The method of claim 7, wherein said composition additionally comprises an additive to increase the mechanical toughness and strength of said compound. 9. A method of claim 1, wherein said biomaterial compound exists as a fine or coarse powder, pellets, three-dimensional shaped pieces, macroporous structures, thin films, and coatings. 10. A method of claim 9, wherein said biomaterial compound exists as a thin film or a coating having a thickness of 0.1 to 10 microns. 11. A method of claim 1, wherein said element is silicon. 12. A method of claim 1, wherein said element is boron. 13. A method of claim 1, wherein said biomaterial compound has the formula (Ca)i[(P1-x-y-zBxCyDz)Oj]2 wherein: B, C and D are selected from those elements having an ionic radius of approximately 0.1 to 0.4.ANG.; x is greater than or equal to zero but less than 1; y is greater than or equal to zero but less than 1; z is greater than or equal to zero but less than 1; x+y+z is greater than zero but less than 1; i is greater than or equal to 2 but less than or equal to 4; and j equals 4-δ, where δ is greater than or equal to zero but less than or equal to 1. 14. A method of claim 13, wherein B is silicon. 15. A method of claim 13, wherein B is boron. 16. A method of claim 1, wherein said biomaterial compound is provided as a composition additionally comprising at least one calcium phosphate material selected from the group consisting of calcium hydroxyapatite, α-TCP, β-TCP, octacalcium phosphate, tetracalcium phosphate, dicalcium phosphate and calcium oxide. 17. A method of claim 16, wherein said composition additionally comprises an additive to increase the mechanical toughness and strength of said compound. 18. A method of claim 2, wherein said biomaterial compound exists as a fine or coarse powder, pellets, three-dimensional shaped pieces, macroporous structures, thin films, and coatings. 19. A method of claim 18, wherein said biomaterial compound exists as a thin film or a coating having a thickness of 0.1 to 10 microns. 20. A method of claim 2, wherein said element is silicon. 21. A method of claim 2, wherein said element is boron. 22. A method of claim 2, wherein said biomaterial compound has the formula (Ca)i[(P1-x-y-zBxCyDz)Oj]2 wherein: B, C and D are selected from those elements having an ionic radius of approximately 0.1 to 0.4 .ANG.; x is greater than or equal to zero but less than 1; y is greater than or equal to zero but less than 1; z is greater than or equal to zero but less than 1; x+y+z is greater than zero but less than 1; i is greater than or equal to 2 but less than or equal to 4; and j equals 4-δ, where δ is greater than or equal to zero but less than or equal to 1. 23. A method of claim 22, wherein B is silicon. 24. A method of claim 22, wherein B is boron. 25. A method of claim 2, wherein said biomaterial compound is provided as a composition additionally comprising at least one calcium phosphate material selected from the group consisting of calcium hydroxyapatite, α-TCP, β-TCP, octacalcium phosphate, tetracalcium phosphate, dicalcium phosphate and calcium oxide. 26. A method of claim 25, wherein said composition additionally comprises an additive to increase the mechanical toughness and strength of said compound. 27. A method of claim 3, wherein said biomaterial compound exists as a fine or coarse powder, pellets, three-dimensional shaped pieces, macroporous structures, thin films, and coatings. 28. A method of claim 27, wherein said biomaterial compound exists as a thin film or a coating having a thickness of 0.1 to 10 microns. 29. A method of claim 3, wherein said element is silicon. 30. A method of claim 3, wherein said element is boron. 31. A method of claim 3, wherein said biomaterial compound has the formula (Ca)i[(P1-x-y-zBxCyDz)Oj]2 wherein: B, C and D are selected from those elements having an ionic radius of approximately 0.1 to 0.4.ANG.; x is greater than or equal to zero but less than 1; y is greater than or equal to zero but less than 1; z is greater than or equal to zero but less than 1; x+y+z is greater than zero but less than 1; i is greater than or equal to 2 but less than or equal to 4; and j equals 4-δ, where δ is greater than or equal to zero but less than or equal to 1. 32. A method of claim 31, wherein B is silicon. 33. A method of claim 31, wherein B is boron. 34. A method of claim 3, wherein said biomaterial compound is provided as a composition additionally comprising at least one calcium phosphate material selected from the group consisting of calcium hydroxyapatite, α-TCP, β-TCP, octacalcium phosphate, tetracalcium phosphate, dicalcium phosphate and calcium oxide. 35. A method of claim 34, wherein said composition additionally comprises an additive to increase the mechanical toughness and strength of said compound. 36. A method of claim 4, wherein said biomaterial compound exists as a fine or coarse powder, pellets, three-dimensional shaped pieces, macroporous structures, thin films, and coatings. 37. A method of claim 36, wherein said biomaterial compound exists as a thin film or a coating having a thickness of 0.1 to 10 microns. 38. A method of claim 4, wherein said element is silicon. 39. A method of claim 4, wherein said element is boron. 40. A method of claim 4, wherein said biomaterial compound has the formula (Ca)i<
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