초록

A once a day bupropion hydrochloride formulation is disclosed.

대표청구항 ▼

1. A controlled release bupropion formulation comprising: (a) a first component comprising immediate release bupropion and its salts, isomers or a pharmaceutically acceptable aminoketone antidepressant; (b) a second component comprising pellets comprising: (i) a core comprising (1) an inert ca

1. A controlled release bupropion formulation comprising: (a) a first component comprising immediate release bupropion and its salts, isomers or a pharmaceutically acceptable aminoketone antidepressant; (b) a second component comprising pellets comprising: (i) a core comprising (1) an inert carrier, (2) bupropion and its salts, isomers, or a pharmaceutically acceptable aminoketone antidepressant agent; and (3) a binder; and (ii) a coating comprising a pH dependent coating agent; and (c) a third component comprising pellets comprising: (i) a core comprising (1) an inert carrier, (2) bupropion and its salts, isomers, or a pharmaceutically acceptable aminoketone antidepressant agent; and (3) a binder; and (ii) a coating comprising (I) a water insoluble methyl acrylic acid copolymer and (II) a water soluble polymer. 2. A controlled release bupropion formulation as defined in claim 1 wherein said immediate release component comprises an inert sugar sphere coated with a layer of binder and bupropion. 3. A controlled release bupropion formulation as defined in claim 2 wherein said immediate release component binder comprises hydroxypropyl methylcellulose. 4. A controlled release bupropion formulation as defined in claim 1 wherein said inert carrier comprises a sugar sphere. 5. A controlled release formulation as defined in claim 1 wherein said binder comprises hydroxypropylmethylcellulose. 6. A controlled release formulation as defined in claim 1 wherein said water insoluble methyl acrylic acid copolymer comprises Eudragit S100. 7. A controlled release formulation as defined in claim 1 wherein said water insoluble polymer comprises ethylcellulose. 8. A controlled release formulation as defined in claim 1 wherein said pH dependent coating comprises hydroxypropyl methylcellulose phthalate.