초록

Topical application of a prostaglandin directly to the clitoris is effective for enhancing female sexual desire and responsiveness.

대표청구항 ▼

1. A method for enhancing female sexual desire and response, comprising topically administering to the clitoris of a subject a pharmaceutical composition containing an effective amount of a prostaglandin on an as-needed basis without regular dosing in the context of a chronic dosage regimen. 2. The

1. A method for enhancing female sexual desire and response, comprising topically administering to the clitoris of a subject a pharmaceutical composition containing an effective amount of a prostaglandin on an as-needed basis without regular dosing in the context of a chronic dosage regimen. 2. The method of claim 1, wherein said prostaglandin is selected from the group consisting of prostaglandin E-1; prostaglandin E-2; prostaglandin F-2α; prostaglandin A-1; prostaglandin B-1; prostaglandin D-2; prostaglandin E-M; prostaglandin F-M; prostaglandin H-2; prostaglandin I-2; 19-hydroxy-prostaglandin A-1; 19-hydroxy-prostaglandin B-1; prostaglandin A-2; prostaglandin B-2; 19-hydroxy-prostaglandin A-2; 19-hydroxy-prostaglandin B-2; prostaglandin B-3; prostaglandin F-1α; 15-methyl-prostaglandin F-2α.; 16,16-dimethyl-α-Δ2-prostaglandin E-1 methyl ester; 15-deoxy-16-hydroxy -16-methyl-prostaglandin E-1 methyl ester; 16,16-dimethyl-prostaglandin E-2; 11-deoxy-15-methyl-prostaglandin E-1; 16-methyl-18,18,19,19-tetrahydrocarbacyclin; (16RS)-15-deoxy-16-hydroxy-16-methyl-prostaglandin E-1 methyl ester; (+)-4,5-didehydro -16-phenoxy-α-tetranor-prostaglandin E-2 methyl ester; 11-deoxy-11a ,16,16-trimethyl -prostaglandin E-2; (+)-11a,16a,b-dihydroxy-1,9-dioxo-1-(hydroxymethyl)-16-methyl -trans-prostene; 9-chloro-16,16-dimethyl-prostaglandin E-2; and arboprostil. 3. The method of claim 1, wherein said prostaglandin is selected from the group consisting of prostaglandin E-1, prostaglandin E-2, prostaglandin F-2α, prostaglandin D-2, prostaglandin F-1α, 15-methyl-prostaglandin F-2α, prostaglandin E-3, prostaglandin D-1, and misoprostol. 4. The method of claim 1, wherein said prostaglandin is applied to said clitoris in an amount of 0.1 nanograms to 2,000 μg. 5. The method of claim 1, wherein said prostaglandin is prostaglandin E-1. 6. The method of claim 1, wherein said prostaglandin is prostaglandin E-2. 7. The method of claim 1, further comprising coadministration of at least one coagent selected from the group consisting of agents which inhibit 15-hydroxyprostaglandindehydrogenase, ACE inhibitors, nitro vasodilators, alpha blockers, yohimbine, labetalol, carvedilol, bucindolol, phosphodiesterase inhibitors, muscarinic agents, dopaminergic agonists, ergot alkaloids, opiate antagonists, and polypeptide neurotransmitters. 8. The method of claim 1, wherein the prostaglandin is a unit dose. 9. The method of claim 8, wherein the unit dose is in the range of about 20 nanograms to about 2000 μg. 10. The method of claim 9, wherein the unit dose is in the range of about 200 nanograms to about 500 μg. 11. The method of claim 1, wherein the pharmaceutical composition further comprises a topical carrier that provides release of the prostaglandin from the composition within about 1 minute to about 60 minutes following administration. 12. The method of claim 11, wherein the carrier provides release of the prostaglandin from the composition within about 5 minutes to about 30 minutes following administration. 13. The method of claim 7, wherein the at least one coagent is administered with the prostaglandin. 14. The method of claim 7, wherein the at least one coagent is administered prior to administration of the prostaglandin. 15. The method of claim 7, wherein the at least one coagent is an agent which inhibits 15-hydroxyprostaglandindehydrogenase.