[특허]Drug coating with topcoat

[미국특허] Drug coating with topcoat 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61F-002/06
출원번호	US-0942716 (2001-08-30)
발명자 / 주소	Ding, Ni Helmus, Michael N.
출원인 / 주소	Boston Scientific Scimed, Inc.
대리인 / 주소	Pennie & Edmonds LLP
인용정보	피인용 횟수 : 74 인용 특허 : 35

초록 ▼

A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat of polymeric material containing an amount of biologically active material, particularly heparin, dispersed therein. The coating further includes a topcoat which covers less than the entire surface of the undercoat and wherein the topcoat comprises a polymeric material substantially free of pores and porosigens. The polymeric material of the topcoat can be a biostable, biocompatible material which provides long term non-thrombogenicity to the device portion during and after release of the biologically active material.

대표청구항 ▼

1. A stent for implantation in a patient comprising a tubular body having open ends and a sidewall and a coating on at least a part of a surface of said sidewall, said coating further comprising an undercoat having an outer surface and comprising a polymeric material incorporating an amount of a biologically active material therein for timed delivery therefrom, and wherein said coating further comprises a topcoat comprising a polymeric material selected from the group consisting of fluorosilicone and polyethylene glycol (PEG), wherein said topcoat covers less than the entire outer surface of the undercoat and wherein said topcoat is substantially free of pores and porosigens. 2. The stent of claim 1 wherein the topcoat covers less than the entire undercoat while the device is implanted. 3. The stent of claim 1 wherein the topcoat covers less than the entire undercoat before the device is implanted. 4. The stent of claim 1 wherein the topcoat covers less than the entire undercoat before the device is implanted and while the device is implanted. 5. The stent of claim 1 wherein the polymeric material of the undercoat is a hydrophobic elastomeric material and wherein the polymeric material of the topcoat is a biostable, biocompatible material which provides long term non-thrombogenicity to the device portion during and after release of the biologically active material. 6. The stent of claim 1 wherein the topcoat reduces a burst release of the biologically active material as compared to a coated stent without the topcoat. 7. The stent of claim 1 wherein the stent is self-expandable and the sidewall comprises at least one opening therein and wherein the coating conforms to said sidewall in a manner that preserves said opening. 8. The stent of claim 1 wherein the biologically active material is heparin. 9. The stent of claim 1 wherein the topcoat covers from about 20% to 85% of the outer surface of the undercoat. 10. The stent of claim 1 wherein the topcoat has an average thickness of about 1 to 5 microns. 11. The stent of claim 1 wherein the topcoat has an average thickness of about the average particle size of the biologically active material.

이 특허에 인용된 특허 (35) 인용/피인용 타임라인 분석

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Ding Ni ; Helmus Michael N., Drug coating with topcoat.
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Winters Suzanne (Salt Lake City UT) Solen Kenneth A. (Orem UT) Sanders Clifton G. (Salt Lake City UT) Mortensen JD (Sandy UT) Berry Gaylord (Salt Lake City UT), Gas permeable thrombo-resistant coatings and methods of manufacture.
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Wolff Rodney G. (Minnetonka Beach MN) Hull Vincent W. (Ham Lake MN), Intralumenal drug eluting prosthesis.
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Nash Harold A. (Harrington Park NJ) Mishell ; Jr. Daniel R. (Palos Verdes Estates CA), Intravaginal ring.
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Lee Hai B. (Taejeon KRX) Shin Bung C. (Taejeon KRX) Khang Gilson (Taejeon KRX) Lee Jin H. (Taejeon KRX), Method of manufacturing a vascular graft impregnated with polysaccharide derivatives.
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Dayton Michael P. (14802 Hadleigh Way Tampa FL 33624), Minimally invasive bioactivated endoprosthesis for vessel repair.
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Winters Suzanne (Salt Lake City UT) Solen Kenneth A. (Orem UT) Sanders Clifton G. (Salt Lake City UT) Mortensen J. D. (Sandy UT) Berry Gaylord (Salt Lake City UT), Multifunctional thrombo-resistant coatings and methods of manufacture.
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Winters Suzanne (Salt Lake City UT) Solen Kenneth A. (Orem UT) Sanders Clifton G. (Salt Lake City UT) Mortensen J. D. (Sandy UT) Berry Gaylord (Salt Lake City UT), Multifunctional thrombo-resistant coatings and methods of manufacture.
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Larm Olle (Nyngsvgen 86 S-161 39 Bromma SEX), Process for covalent coupling for the production of conjugates, and polysaccharide containing products thereby obtained.
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Wallsten Hans I. (Denens CHX), Prosthesis comprising an expansible or contractile tubular body.
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Wallstn Hans I. (Denens CHX), Prosthesis comprising an expansible or contractile tubular body.
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Wallstn Hans I. (Denens CHX) Imbert Christian (Mzires CHX), Self-expanding prosthesis.
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Margraf Harry W. (Clayton MO), Siver-heparin-allantoin complex.
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Fearnot Neal E. (West Lafayette IN) Ragheb Anthony O. (West Lafayette IN) Voorhees ; III William D. (West Lafayette IN), Thrombolytic treated intravascular medical device.
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Keogh James R. (Maplewood MN), Thromboresistant articles.
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