초록 ▼

The invention relates to a pharmaceutical implant for controllably releasing a drug in a subject and methods for manufacturing and administering the implant. The implant is made of associated microparticles of a drug dispersed in a biodegradable polymer. The microparticles are sufficiently associate

The invention relates to a pharmaceutical implant for controllably releasing a drug in a subject and methods for manufacturing and administering the implant. The implant is made of associated microparticles of a drug dispersed in a biodegradable polymer. The microparticles are sufficiently associated so that the implant maintains a predetermined shape but are not fused together so as to form a single monolithic structure. The drug can be controllably released in a subject by administration of the pharmaceutical implant without the need of a suspending fluid.

대표청구항 ▼

The invention relates to a pharmaceutical implant for controllably releasing a drug in a subject and methods for manufacturing and administering the implant. The implant is made of associated microparticles of a drug dispersed in a biodegradable polymer. The microparticles are sufficiently associate

The invention relates to a pharmaceutical implant for controllably releasing a drug in a subject and methods for manufacturing and administering the implant. The implant is made of associated microparticles of a drug dispersed in a biodegradable polymer. The microparticles are sufficiently associated so that the implant maintains a predetermined shape but are not fused together so as to form a single monolithic structure. The drug can be controllably released in a subject by administration of the pharmaceutical implant without the need of a suspending fluid. laimed in claim 1, wherein the second layer comprises a laminate of plural layers containing silicon dioxide as a principal component obtained by separately heat-treating plural solutions having different contents of polyorganosilazane. 5. A coating film as claimed in claim 1, wherein the base comprises a material selected from the group consisting of a metal, ceramic and a synthetic resin. 6. A coating film, formed on at least a portion of a base, comprising: a dense layer containing silicon dioxide as a principal component, which is obtained by heat-treating a solution containing perhydropolysilazane and polyorganosilazane, a ratio of the content of perhydropolysilazane to the total amount of polysilazane including perhydropolysilazane and polyorganosilazane being from 0.95 to 1.0; and a second layer containing silicon dioxide as a principal component formed on the dense layer, the second layer being obtained by heat-treating a second solution containing perhydropolysilazane and polyorganosilazane, the content of polyorganosilazane being larger than that of the solution. 7. A coating film as claimed in claim 6, further comprising a third layer containing silicon dioxide as a principal component formed on the second layer, the third layer being obtained by heat-treating a third solution containing perhydropolysilazane and polyorganosilazane, the content of polyorganosilazane being less than that of the second layer. 8. A coating film as claimed in claim 6, wherein the second layer comprises a laminate of plural layers containing silicon dioxide as a principal component obtained by separately heat-treating plural solutions having different contents of polyorganosilazane. 9. A coating film as claimed in claim 6, further comprising an adhesion improved layer formed between the base and the dense layer. 10. A coating film as claimed in claim 6, wherein the base comprises a material selected from the group consisting of a metal, ceramic, and a synthetic resin. 11. A coating film, formed on at least a portion of a base, comprising: a flexible layer containing silicon dioxide as a principal component, which is obtained by heat-treating a solution containing perhydropolysilazane and polyorganosilazane, a ratio of the content of perhydropolysilazane to the total amount of polysilazane including perhydropolysilazane and polyorganosilazane being from 0 to 0.65; and a second layer containing silicon dioxide as a principal component formed on the flexible layer, the second layer being obtained by heat-treating a second solution containing perhydropolysilazane and polyorganosilazane, the content of polyorganosilazane being less than that of the solution. 12. A coating film as claimed in claim 11, wherein the flexible layer and/or the second layer comprise a laminate of plural layers containing silicon dioxide as a principal component obtained by separately heat-treating plural solutions having different contents of polyorganosilazane. 13. A coating film as claimed in claim 11, further comprising an adhesion improved layer formed between the base and the flexible layer. 14. A coating film as claimed in claim 11, wherein the base comprises a material selected from the group consisting of a metal, ceramic, and a synthetic resin. ciency in contrast to the desired nondecreasing removal efficiency for the filter as a whole.