초록 ▼

Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. The mixture is formed into micropart

Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. The mixture is formed into microparticles that are dispersed within bioabsorbable hydrogels, so as to release the water soluble therapeutic agents in a controlled fashion. Methods of using the compositions of the present invention in therapeutic systems are also provided.

대표청구항 ▼

Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. The mixture is formed into micropart

Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. The mixture is formed into microparticles that are dispersed within bioabsorbable hydrogels, so as to release the water soluble therapeutic agents in a controlled fashion. Methods of using the compositions of the present invention in therapeutic systems are also provided. ., "Absorption of Diltiazem in Beagle Dog from Pulsatile Release Tablet," Chem. Pharm. Bull. 40(11):3094-3096 (Nov. 1992). Koeter, G.H. et al., "Pharmacokinetics of Sustained Release Theorphylline in Low and High Multidose Regimens," Br. J. clin. Pharmac. 12:647-651 (Nov. 1981). Krogel, I. and R. Bodmeier, "Pulsatile Drug Release form an Insoluble Capsule Body Controlled by an Erodible Plug," Pharmaceut. Res. 15(3):474-481 (Mar. 1998). Lin, S.-Y. et al., "Theophylline Biovailability After Single Oral Administration of Sustained-Release Microcapusles," Curr. Therapeut. Res. 42(4):564-573 (Oct. 1987). Lippold, B.C. and J.E. Mockel, "Pulsatile Release from Laminated Methylhydroxy-propyl Cellulose Matrices with KCL as Model Drug," Acta Pharm. Technol. 36(2):97-98 (1990). Munday, D.L., "Bimodal in vitro release from polymeric matrix tablets containing centralised drug cores," S.T.P. Pharma Sci. 6(3):182-187 (May-Jun. 1996). Otsuka, M. and Y. Matsuda, "Controlled Drug Release of Highly Water-Soluble Pentoxifylline from Time-Limit Disintegration-Type Wax Matrix Tablets," Pharmaceut. Res. 11(3):351-354 (Mar. 1994). Robert, D. et al., "Epilim.RTM. Chrono: A Multidose, Crossover Comparison of Two Formulatons of Valproate in Healthy Volunteers," Biopharmaceut. & Drug Dispos. 17(2):175-182 (Mar. 1996). Rohatagi, S. et al., "Pharmacokinetic Evaluation of a Selegiline Pulsatile Oral Delivery System," Biophamaceut. & Drug Dispos. 18(8):665-680 (Nov. 1997). Sarna, S.K, "Physiology and Pathophysiology of Colonic Motor Activity," Digestive Dis. Sci. 36(6):827-862 (Jun. 1991). Sarna, S.K., "Physiology and Pathophysiology of Colonic Motor Activity," Digestive Dis. Sci. 36(7):998-1018 (Jul. 1991). Schwartz, J. et al., "Impact of Ciprofloxacin on Theophylline Clearance and Steady-State Concentrations in Serum," Antimicrobial Agents Chemother. 32(1):75-77 (Jan. 1988). Stevens, R.E. et al., "Controlled, Multidose, Pharmacokinetic Evaluation of two Extended-Release Carbamazepine Formulations (Carbatrol and Tegretol-XR)," J. Pharmaceut. Sci. 87(12):1531-1534 (Dec. 1998). Warren, R.J. et al., "Pharmaceutical Applications of Internal Reflectance Spectroscopy," Microchem. J. 12(4):555-567 (Dec. 1967).